Assuntos
Eritema Infeccioso/patologia , Dermatoses do Pé/patologia , Dermatoses da Mão/patologia , Parvovirus B19 Humano , Púrpura/patologia , Adulto , Feminino , Dermatoses do Pé/tratamento farmacológico , Dermatoses da Mão/tratamento farmacológico , Humanos , Púrpura/tratamento farmacológico , Síndrome , Fatores de Tempo , Procedimentos DesnecessáriosRESUMO
BACKGROUND: No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties. OBJECTIVE: To compare the efficacy and tolerability of SA and CDP combination (SA+CDP) with all-TRA and CDP (all-TRA+CDP) in patients with mild to moderate facial AV. METHODS: Forty-six patients aged between 18 and 35 years were enrolled in a 12-week prospective, single-blind, randomized and comparative clinical study. Efficacy was assessed by lesion counts, global improvement, quality of life index and measurement of skin barrier functions. Local side effects were also evaluated. RESULTS: Both combinations were effective in reducing total lesion (TL), inflammatory lesion (IL) and non-inflammatory lesion (NIL) counts and showed significant global improvement as evaluated by the investigator. At the end of the study, there was no significant difference between the two groups in terms of all lesion counts. In addition, TL counts decreased faster in the all-TRA+CDP group compared with those in the SA+CDP group, with a significant difference between the two groups occurring as early as 2 weeks. Safety evaluations demonstrated that the incidence of mild to moderate side effects generally peaked at week 2 and declined gradually thereafter. Both combinations did not have an effect on stratum corneum hydration, although skin sebum values decreased with SA+CDP treatment. CONCLUSIONS: Combination of SA+CDP and all-TRA+CDP was effective in decreasing lesion counts and well tolerated with minimal local cutaneous reactions in patients with mild to moderate AV.
Assuntos
Acne Vulgar/tratamento farmacológico , Ceratolíticos/uso terapêutico , Ácido Salicílico/uso terapêutico , Tretinoína/uso terapêutico , Acne Vulgar/psicologia , Administração Tópica , Adolescente , Adulto , Clindamicina/administração & dosagem , Clindamicina/efeitos adversos , Clindamicina/análogos & derivados , Clindamicina/uso terapêutico , Relação Dose-Resposta a Droga , Quimioterapia Combinada , Feminino , Humanos , Ceratolíticos/administração & dosagem , Ceratolíticos/efeitos adversos , Masculino , Pomadas , Estudos Prospectivos , Qualidade de Vida/psicologia , Ácido Salicílico/administração & dosagem , Ácido Salicílico/efeitos adversos , Índice de Gravidade de Doença , Método Simples-Cego , Resultado do Tratamento , Tretinoína/administração & dosagem , Tretinoína/efeitos adversos , Adulto JovemRESUMO
Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes. Direct immunofluorescence examination revealed intercellular Ig G and C(3) within the epidermis. We were unable to find a similar case of papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence findings reported in the literature, thus in this report, the clinicopathological features of a unique case are presented.
Assuntos
Acantólise/patologia , Doenças dos Genitais Femininos/patologia , Ceratose/patologia , Adulto , Diagnóstico Diferencial , Feminino , Técnica Direta de Fluorescência para Anticorpo , HumanosRESUMO
BACKGROUND: Different protocols have been used for narrowband ultraviolet B (UVB) therapy, commonly used in the treatment of psoriasis; however, more effective and reliable protocols are still required. OBJECTIVE: The aim of this study was to compare the weekly and daily dose increment protocols of narrowband UVB phototherapy in psoriasis patients. METHODS: Thirty patients with plaque psoriasis underwent narrowband UVB treatment three times a week and 15 patients selected consecutively among these patients underwent a weekly (once in three treatments) dose increment whereas the remaining 15 patients underwent a daily dose increment. Patients were monitored for 10 weeks and evaluated by the Psoriasis Area Severity Index (PASI). RESULTS: When the two groups were evaluated according to median PASI scores prior to the treatment and during 10 weeks of treatment, there was no statistically significant difference between the groups (P > 0.05). During the treatment lasting for 10 weeks, four patients in the group with a weekly dose increment and three patients in the group with a daily dose increment recovered and no statistically significant difference was detected between the groups (P > 0.05). The groups were also evaluated according to the median cumulative dose. The median cumulative dose was higher in the group with a daily dose increment and the difference between the groups was statistically significant (P = 0.002). CONCLUSION: The application of daily dose increments was no better than that of weekly dose increments in narrowband UVB treatment for psoriasis. Therefore, although our results may need to be supported by large-series studies, we conclude that application of weekly dose increments with a lower cumulative dose having the same efficacy is preferred in narrowband UVB treatment of psoriasis.
Assuntos
Psoríase/radioterapia , Terapia Ultravioleta/métodos , Adulto , Idoso , Relação Dose-Resposta à Radiação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Fatores de TempoRESUMO
A 73-year-old man with porokeratosis palmaris, plantaris et disseminata is presented. He had punctate, guttate and annular hyperkeratotic papular lesions widespread on his body with thorn-like hyperkeratosis on the palms and soles. Lesional skin did not show mutations of TP53 exons 5-6, 7, 8.
Assuntos
Poroceratose/patologia , Proteína Supressora de Tumor p53/genética , Adolescente , Idoso , DNA/genética , Saúde da Família , Humanos , Masculino , Pessoa de Meia-Idade , Mutação , Linhagem , Polimorfismo Conformacional de Fita Simples , Poroceratose/genética , Células Tumorais CultivadasRESUMO
BACKGROUND: Borrelia burgdorferi (Bb) infection has been implicated in the development of morphea and lichen sclerosus; however, conflicting results have been reported with different investigational methods from different regions. We looked for evidence of Bb in patients with morphea and lichen sclerosus by polymerase chain reaction (PCR) analysis of of skin biopsy samples. METHODS: Formalin-fixed, paraffin-embedded skin biopsy samples from 10 patients with morphea and 12 patients with lichen sclerosus were investigated by PCR analysis for the presence of Bb. RESULTS: The presence of Bb DNA was demonstrated in three of 10 patients with morphea and six of 12 patients with lichen sclerosus by nested PCR. CONCLUSIONS: The data obtained in this study suggest that Bb may play a role in the etiopathogenesis of both morphea and lichen sclerosus at least in the western parts of Turkey.
Assuntos
Grupo Borrelia Burgdorferi/isolamento & purificação , Líquen Escleroso e Atrófico/microbiologia , Doença de Lyme/microbiologia , Esclerodermia Localizada/microbiologia , Adolescente , Adulto , Idoso , Grupo Borrelia Burgdorferi/genética , Criança , Primers do DNA/química , DNA Bacteriano/análise , Feminino , Humanos , Líquen Escleroso e Atrófico/patologia , Doença de Lyme/patologia , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Esclerodermia Localizada/patologia , Pele/microbiologia , Pele/patologiaAssuntos
Fármacos Dermatológicos/uso terapêutico , Aprovação de Drogas , Uso de Medicamentos , Hormônios/uso terapêutico , Dermatopatias/tratamento farmacológico , Corticosteroides/uso terapêutico , Anabolizantes/uso terapêutico , Antagonistas de Androgênios/uso terapêutico , Androgênios/uso terapêutico , Estrogênios/uso terapêutico , Hormônio do Crescimento Humano/uso terapêutico , Humanos , Hormônios Tireóideos/uso terapêutico , Estados Unidos , United States Food and Drug AdministrationRESUMO
Anetoderma is a rare disorder of cutaneous atrophy with loss of dermal elastic tissue. Secondary anetoderma is seen after a variety of dermatoses. We describe a 33-year-old woman with secondary anetoderma after generalized granuloma annulare lesions that were most pronounced on sun-exposed areas.
Assuntos
Granuloma Anular/complicações , Pele/patologia , Adulto , Atrofia/etiologia , Atrofia/patologia , Biópsia , Doença Crônica , Feminino , Granuloma Anular/patologia , HumanosRESUMO
BACKGROUND: Recent investigation of the etiology of Behçet's disease (BD) has focused on heat shock proteins (HSP) which belong to the HSP 60 family. Both the gastric pathogen Helicobacter pylori (HP) and BD may cause ulcers in the gastrointestinal tract and, HP expresses HSP 60. OBJECTIVE: Whether HP is linked to the pathogenesis of BD or not, and to investigate the influence of HP eradication on clinical parameters of BD. METHODS: Patients with BD were divided into two groups. Group I comprised 49 patients and was investigated for HP seroprevalence and compared with age- and sex-matched controls. Group II comprised 20 patients with BD and HP infection diagnosed by serological and endoscopic examinations as well as the rapid urease test (RUT). A 1-week eradication therapy was administered for HP infection. Patients were examined for the course of BD at monthly intervals. Two months after the eradication therapy, patients underwent an endoscopic examination and RUT for eradication control. Seven patients were excluded because of eradication failure. Thirteen patients were evaluated for the influence of HP eradication on clinical manifestations of BD. The number and size of oral and genital ulcers before the eradication and at the end of the follow-up period were compared statistically. RESULTS: HP seroprevalence between patients with BD and controls did not show significant difference. In 13 patients with BD, the number and size of oral and genital ulcers diminished significantly and various clinical manifestations regressed after the eradication of HP. CONCLUSION: HP may be involved in the pathogenesis of BD.
Assuntos
Síndrome de Behçet/microbiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/patogenicidade , Adolescente , Adulto , Anticorpos Antibacterianos/sangue , Síndrome de Behçet/diagnóstico , Endoscopia Gastrointestinal , Feminino , Seguimentos , Gastrite/diagnóstico , Infecções por Helicobacter/sangue , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/terapia , Helicobacter pylori/enzimologia , Humanos , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Testes Sorológicos , Urease/metabolismoRESUMO
We report the first case of an acquired form of generalized cutis laxa which has positive serology and a positive polymerase chain reaction (PCR) result for lyme borreliosis. A 44-year-old man complained of excessively loose skin for four years and had no family history of any skin disease. Dermatological examination showed lax and wrinkled skin all over the body (especially on the cheeks and the intertriginous areas). Positive serology for lyme borreliosis and the presence of Borrelia burgdorferi DNA which was demonstrated by nested PCR in this acquired form of cutis laxa is interesting since it has not been reported in literature previously.
Assuntos
Cútis Laxa/patologia , Pele/patologia , Adulto , Grupo Borrelia Burgdorferi/genética , Grupo Borrelia Burgdorferi/imunologia , Cútis Laxa/imunologia , DNA Bacteriano/análise , Feminino , Humanos , Doença de Lyme/imunologia , Masculino , Reação em Cadeia da Polimerase , Pele/metabolismoRESUMO
We describe a patient with persistent papular acantholytic dermatosis provoked by phototoxic reaction to his usual perfumed soap and shaving foam. Therapy with systemic and topical corticosteroids failed to improve the patient. Treatment with cyclosporine was found to be effective.
Assuntos
Ciclosporina/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Dermatopatias Papuloescamosas/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Pele/efeitos dos fármacos , Pele/patologia , Dermatopatias Papuloescamosas/patologia , Resultado do TratamentoAssuntos
Cordoma/patologia , Neoplasias Cutâneas/patologia , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Tuberculose Cutânea/diagnóstico , Biópsia , DNA Bacteriano/análise , Quimioterapia Combinada , Feminino , Humanos , Isoniazida/uso terapêutico , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Reação em Cadeia da Polimerase , Rifampina/uso terapêutico , Pele/patologia , Tuberculose Cutânea/tratamento farmacológicoAssuntos
Síndrome de Behçet/tratamento farmacológico , Ciclosporina/uso terapêutico , Imunossupressores/uso terapêutico , Adulto , Síndrome de Behçet/patologia , Feminino , Doenças dos Genitais Femininos/patologia , Doenças dos Genitais Masculinos/patologia , Humanos , Masculino , Mucosa , Úlceras Orais/patologia , Dermatopatias/patologia , ÚlceraRESUMO
We report a case of Hutchinson-Gilford progeria syndrome (HGPS). The patient showed the characteristics of scleredema at the age of 2.5 months but developed all the manifestations of HGPS gradually until 10 months old. The possibility of development of HGPS should by considered in any case of scleredema at birth or in early infancy.
Assuntos
Progéria/diagnóstico , Esclerema Neonatal/diagnóstico , Alopecia/patologia , Pré-Escolar , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Progéria/patologia , Esclerema Neonatal/patologiaRESUMO
In the years 1979 and 1980 after the religious holidays of the "Feast of Sacrifice" in Izmir (Turkey), there was an epidemic-type of outbreak of 31 cases of ecthyma contagiosum. On the occasion of the sacrificial feast day the amateur butchers, their helpers, housewives, and others came into direct contact with virus-infected parts and were infected with the ecthyma contagiosum virus, which includes the paravaccinia group.