1.
Bioorg Med Chem Lett
; 16(24): 6316-20, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17010605
RESUMO
A new class of benzimidazolone p38 MAP kinase inhibitors was discovered through high-throughput screening. X-ray crystallographic data of the lead molecule with p38 were used to design analogues with improved binding affinity and potency in a cell assay of LPS-induced TNFalpha production. Herein, we report the SAR of this new class of p38 inhibitors.