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Objective: To evaluate the diagnostic performance of computed tomography (CT) fluoroscopy-guided percutaneous transthoracic needle biopsy (PTNB) in pulmonary nodules ≤ 10 mm during the coronavirus disease 2019 pandemic. Materials and Methods: Between January 1, 2020 and April 30, 2022, a total of 359 CT fluoroscopy-guided PTNBs were performed at an interventional radiology center. Lung lesions measured between 2 mm and 108 mm. Of the 359 PTNBs, 27 (7.5%) were performed with an 18G core needle on nodules ≤ 10 mm in diameter. Results: Among the 27 biopsies performed on nodules ≤ 10 mm, the lesions measured < 5 mm in four and 5-10 mm in 23. The sensitivity and overall diagnostic accuracy of PTNB were 100% and 92.3%, respectively. The mean dose of ionizing radiation during PTNB was 581.33 mGy*cm (range, 303-1,129 mGy*cm), and the mean biopsy procedure time was 6.6 min (range, 2-12 min). There were no major postprocedural complications. Conclusion: CT fluoroscopy-guided PTNB appears to provide a high diagnostic yield with low complication rates.
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Resumo Objetivo: Avaliar o desempenho diagnóstico da biópsia pulmonar percutânea transtorácica (BPPT) guiada por fluoroscopia associada a tomografia computadorizada (FTC) em nódulos pulmonares ≤ 10 mm no período de pandemia de COVID-19. Materiais e Métodos: No período de 1º de janeiro de 2020 a 30 de abril de 2022, 359 BPPTs guiadas por FTC foram realizadas em um centro terciário de radiologia intervencionista. As lesões pulmonares mediam entre 2 mm e 108 mm. Dessas 359 BPPTs, 27 (7,5%) foram realizadas com agulha 18G em nódulos de 2 mm a 10 mm. Resultados: Das 27 BPPTs realizadas nos nódulos ≤ 10 mm, quatro lesões tinham dimensões menores que 5 mm e 23 lesões mediam entre 5 e 10 mm. Sensibilidade e acurácia diagnóstica das BPPTs guiadas por FTC foram de 100% e 92,3%, respectivamente. A dose média de radiação ionizante para os pacientes durante o procedimento de BPPT guiada por FTC foi de 581,33 mGy*cm, variando de 303 a 1129 mGy*cm. A média de tempo dos procedimentos de biópsia foi de 6,6 minutos, variando de 2 a 12 minutos. Nas 27 BPPTs, nenhuma complicação maior foi descrita. Conclusão: A BBPT guiada por FTC resultou em alto rendimento diagnóstico e baixas taxas de complicações.
Abstract Objective: To evaluate the diagnostic performance of computed tomography (CT) fluoroscopy-guided percutaneous transthoracic needle biopsy (PTNB) in pulmonary nodules ≤ 10 mm during the coronavirus disease 2019 pandemic. Materials and Methods: Between January 1, 2020 and April 30, 2022, a total of 359 CT fluoroscopy-guided PTNBs were performed at an interventional radiology center. Lung lesions measured between 2 mm and 108 mm. Of the 359 PTNBs, 27 (7.5%) were performed with an 18G core needle on nodules ≤ 10 mm in diameter. Results: Among the 27 biopsies performed on nodules ≤ 10 mm, the lesions measured < 5 mm in four and 5-10 mm in 23. The sensitivity and overall diagnostic accuracy of PTNB were 100% and 92.3%, respectively. The mean dose of ionizing radiation during PTNB was 581.33 mGy*cm (range, 303-1,129 mGy*cm), and the mean biopsy procedure time was 6.6 min (range, 2-12 min). There were no major postprocedural complications. Conclusion: CT fluoroscopy-guided PTNB appears to provide a high diagnostic yield with low complication rates.
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INTRODUÇÃO: A core biopsy (CB) tem ganhado espaço cada vez mais importante no diagnóstico e no manejo do câncer de mama devido a seu baixo custo e alta acurácia. Entretanto, devemos nos perguntar se esse método realmente é adequado para a caracterização do tipo histológico e do grau de diferenciação tumoral, uma vez que a região biopsiada pode não ser representativa do tumor como um todo. OBJETIVO: Avaliar a concordância entre o anatomopatológico da biópsia e o encontrado na peça cirúrgica. MATERIAL E MÉTODOS: Realizamos um estudo retrospectivo envolvendo todos os pacientes com câncer de mama submetidos à mastectomia radical modificada ou à quadrantectomia em nosso serviço, entre janeiro de 2007 a dezembro 2009, analisando a taxa de concordância entre o resultado da CB do tumor de mama e o anatomopatológico da peça cirúrgica. Estudamos como variáveis o tipo histológico e o grau de diferenciação tumoral e de invasão linfovascular. RESULTADOS: Os resultados mostraram taxa de concordância para tipo histológico de 76 por cento entre os métodos. Já a concordância para o grau tumoral foi de 50 por cento, observando-se uma tendência da CB a subestimar o grau. Em relação à presença de invasão linfovascular, ocorreram 62,09 por cento de concordância, sendo 100 por cento seu valor preditivo positivo (VPP), mas com baixa sensibilidade (29 por cento). CONCLUSÃO: Esses achados sugerem que a CB seja o método adequado para o diagnóstico histológico do câncer de mama, porém apresenta alta taxa de discordância para grau tumoral e invasão linfovascular com o exame anatomopatológico da peça cirúrgica, tendendo a subestimar a agressividade do tumor.
INTRODUCTION: Core biopsy (CB) has increasingly gained importance in the diagnosis and management of breast cancer due to its cost effectiveness and high accuracy. However, it is debatable whether this method is particularly suitable for the characterization of histological type and tumor differentiation, since the biopsied region may not be representative of the tumor as a whole. OBJECTIVE: To evaluate the concordance between the biopsy and the surgical specimen anatomopathological findings. MATERIAL AND METHODS: We carried out a retrospective study involving all patients with breast cancer undergoing modified radical mastectomy or quadrantectomy in our service from January 2007 to December 2009, thus analyzing the concordance rate between the results of breast tumor CB and surgical specimen anatomopathology. Histological type, tumor differentiation grade and lymphovascular invasion were assessed as variables. RESULTS: The results show a concordance rate of 76 percent for the histological type between both methods. As to tumor grade, concordance rate was 50 percent, in which CB was prone to underestimate grade. Regarding the presence of lymphovascular invasion, the concordance was 62.09 percent, with 100 percent positive predictive value but low sensitivity (29 percent). CONCLUSION: These findings suggest that CB is a suitable method for histological diagnosis of breast cancer, although it has a high discordance rate for tumor grade and lymphovascular invasion in comparison with specimen anatomopathologic exam, tending to underestimate tumor aggressiveness.