Pyrolytic carbon head shoulder arthroplasty: CT scan glenoid bone modeling assessment and clinical results at 3-year follow-up.

Background: The aim of this study is to report the radiological glenoid modifications and clinical outcomes at 3 years mean follow-up of hemi shoulder arthroplasty (HA) with pyrocarbon (PYC) humeral head. Our hypothesis was that the PYC implants would provide good outcomes without major glenoid erosion. Additionally, we hypothesized that HA-PYC allowed for remodeling of the bone. Methods: Patients underwent HA with PyC humeral head for treatment of primary or secondary osteoarthritis, excluding post-traumatic cases. All patients had a Constant Score assessed preoperatively and at the last follow-up. Preoperative and postoperative computed tomography scans at the last follow-up were performed to achieve 3-dimensional reconstructions of the scapulae. Deformities of the glenoid surface were analyzed as a distance differential between postoperative and preoperative to investigate potential bone remodeling vs. glenoid erosion. The subluxation index (SLI) was measured. Results: We included 41 patients implanted with a HA-PYC. Average age at the time of implant was 63.8 (40 to 79 years). All patients were followed for ≥2 years with an average follow-up of 36.3 months (24 to 60 months). Constant Scores increased from 34 at baseline to 80 at the last follow-up points on average (P < .01). Return to work rate was 100% and 96% had resumed their physical activity. Ten (77%) of the 13 patients with posterior head subluxation had normalized their SLI. Furthermore, no significant differences were detected between the individuals having corrected their posterior subluxation and the others (preoperative SLI between 0.45 and 0.55). Glenoid wear is less than 0.6 mm at 3 years mean follow-up, ie, 5 times less than metallic implants. A tendency to recenter the head in the anteroposterior plane was found in type B glenoid, without increased erosion of the glenoid, with very good clinical results. We did not find any difference according to age or glenoid type for clinical and radiological results. Conclusion: HA-PYCs give, in the short term, excellent clinical results in terms of pain and function. The development of a precise and objective measurement method has made it possible to demonstrate that the glenoid surface is the site of modifications that may be part of bone remodeling or progression of the osteoarthritis disease.

Is routine gleno-humeral exploration a risk factor for adhesive capsulitis after arthroscopic removal of rotator cuff calcifications? A comparative retrospective study in 340 cases.

BACKGROUND: Arthroscopic surgery has earned its place as the reference standard treatment for rotator cuff calcific tendinopathy refractory to conservative medical treatment. Adhesive capsulitis of the shoulder is the most common complication (12%). Standard practice involves routine gleno-humeral exploration before calcification removal. The objective of this study was to identify risk factors for adhesive capsulitis. HYPOTHESIS: The development of adhesive capsulitis is associated with gleno-humeral exploration. METHODS: We conducted a multicentre, multi-surgeon, retrospective cohort study of 340 consecutive patients who underwent arthroscopic removal of rotator cuff calcifications between 1 January 2012 and 1 January 2018. We collected epidemiological data (age, sex, work-related physical activity), the history of previous treatments (local injections, needling), the type and location of the calcifications as assessed radiologically, the clinical findings (Constant score before and 6 months after surgery, diagnosis of adhesive capsulitis defined as shoulder pain with motion range limitation in all directions), and the surgical details (type of anaesthesia, gleno-humeral exploration). RESULTS: Of the 340 patients, 251 underwent routine gleno-humeral exploration and 89 did not. Adhesive capsulitis developed in 40 (12%) patients. By multivariate analysis, gleno-humeral exploration was an independent risk factor for adhesive capsulitis (p=0.022; odds ratio, 5.60). Of the 251 gleno-humeral explorations, 8% identified concomitant lesions and only 4% led to a curative procedure. CONCLUSION: Given our results and the data in the literature, we believe that routine gleno-humeral exploration during the arthroscopic treatment of rotator cuff calcific tendinopathy is inadvisable. LEVEL OF EVIDENCE: III; case-control study.

Analysis of parameters influencing intraarticular temperature during radiofrequency use in shoulder arthroscopy.

PURPOSE: The aim of this study was to analyze the influence of several factors on the temperature in the work chamber during shoulder arthroscopy procedures in order to identify danger zones when using radiofrequency. METHODS: Intraarticular temperature was measured intraoperatively using system with special probe that directly measured the temperature in 22 patients. Data collection was prospective. The main parameters studied were the measurement of the temperature depending on: localization of the procedure (glenohumeral or subacromial), the use of coagulation or ablation, the number of portals, the pressure of the arthropump, the time of use, the blood pressure and the temperature of the operating room. RESULTS: Ninety-three recordings were made. No complications were identified. Addition of a portal reduces the average elevation of 3.8 °C (p < 0.05). Ambient temperature above 19.15 °C with two portals leads to an average increase of 13.3 °C (p < 0.05). Increasing the pressure of the arthropump of 10 mmHg increases the temperature of 0.8 °C (p < 0.05). No significant difference was found on the change in blood pressure, location and mode of use. CONCLUSIONS: These results show the interest of controlling these factors when performing shoulder arthroscopy procedure. This study identifies situations of high joint risk when using radiofrequency and thus to prevent secondary complications such as burns and massive chondrolyses.

Three- and four-part displaced proximal humeral fractures in patients older than 70 years: reverse shoulder arthroplasty or nonsurgical treatment?

BACKGROUND: The objective of our study was to evaluate the results of surgical treatment by reverse shoulder arthroplasty (RSA) compared with nonsurgical treatment after 2 years of follow-up in patients aged 70 years or older with displaced 3-part or 4-part proximal humeral fractures. METHODS: Two groups were formed: the RSA group (n = 28) and the nonsurgical group (n = 32). Minimum follow-up was 2 years. We included patients with 3-part or 4-part fractures according to the Neer classification. Main outcome measures were the Constant-Murley score, the 11-item version of the Disabilities of the Arm, Shoulder and Hand score, and the Subjective Shoulder Value score. An autonomy score, a cognitive assessment score, and a pain score were also measured. RESULTS: Clinical features in the 2 groups were not significantly different. The Constant-Murley mean score was significantly higher for the RSA group (82.1% vs. 76.8%; P = .03). Amplitudes were all higher in favor of the RSA group (P < .02). There was no significant difference in mean score on the 11-item version of the Disabilities of the Arm, Shoulder and Hand score, the preoperative and postoperative Subjective Shoulder Value score, the autonomy score, the cognitive assessment score, or the pain score in both groups at the last follow-up. The complication rate was higher for the RSA group. CONCLUSIONS: These results suggest that RSA treatment of proximal humeral fractures with 3-part or 4-part displaced fragments in elderly patients provides better functional outcomes than does nonsurgical treatment. However, the observed clinical difference was relatively small. This solution must be proposed only to patients who have a significant functional demand.

Arthroscopy-assisted fixation of fracture of the distal part of the clavicle by subcoracoid suture and clavicle button.

INTRODUCTION: Neer IIB displaced fracture of the distal part of the clavicle is often treated surgically. Arthroscopy-assisted surgery was recently developed. The aim of the present study was to present an original technique of subcoracoid suture under arthroscopy, with clinical and radiological results. HYPOTHESIS: Arthroscopy-assisted subcoracoid suture in Neer IIB clavicle fracture provides satisfactory results. MATERIAL AND METHODS: Fourteen patients, with a mean age of 34.6 years (range, 24-51 years) with Neer IIB displaced clavicle fracture treated by subcoracoid suture between January 2013 and January 2017 were included. Clinical assessment comprised demographic data, weighted Constant score and Subjective Shoulder Value (SSV). Radiologic assessment comprised AP shoulder view. RESULTS: Bone healing was systematic within 3 months, except in 1 case of delayed healing. Mean follow-up was 20 months (range, 6-55 months). At last follow-up, mean weighted Constant score was 91% (range, 85-95%) and mean SSV 95% (range, 85-100%). 4 patients reported clavicle button irritation, 2 of whom asked for hardware removal. DISCUSSION: Arthroscopy-assisted subcoracoid suture provided satisfactory clinical results. There were no cases of implant failure, probably because the technique caused no iatrogenic coracoid trauma. Clavicle button irritation sometimes required hardware removal. LEVEL OF EVIDENCE: IV.

Method for semi-automated microscopy of filtration-enriched circulating tumor cells.

BACKGROUND: Circulating tumor cell (CTC)-filtration methods capture high numbers of CTCs in non-small-cell lung cancer (NSCLC) and metastatic prostate cancer (mPCa) patients, and hold promise as a non-invasive technique for treatment selection and disease monitoring. However filters have drawbacks that make the automation of microscopy challenging. We report the semi-automated microscopy method we developed to analyze filtration-enriched CTCs from NSCLC and mPCa patients. METHODS: Spiked cell lines in normal blood and CTCs were enriched by ISET (isolation by size of epithelial tumor cells). Fluorescent staining was carried out using epithelial (pan-cytokeratins, EpCAM), mesenchymal (vimentin, N-cadherin), leukocyte (CD45) markers and DAPI. Cytomorphological staining was carried out with Mayer-Hemalun or Diff-Quik. ALK-, ROS1-, ERG-rearrangement were detected by filter-adapted-FISH (FA-FISH). Microscopy was carried out using an Ariol scanner. RESULTS: Two combined assays were developed. The first assay sequentially combined four-color fluorescent staining, scanning, automated selection of CD45(-) cells, cytomorphological staining, then scanning and analysis of CD45(-) cell phenotypical and cytomorphological characteristics. CD45(-) cell selection was based on DAPI and CD45 intensity, and a nuclear area >55 µm(2). The second assay sequentially combined fluorescent staining, automated selection of CD45(-) cells, FISH scanning on CD45(-) cells, then analysis of CD45(-) cell FISH signals. Specific scanning parameters were developed to deal with the uneven surface of filters and CTC characteristics. Thirty z-stacks spaced 0.6 µm apart were defined as the optimal setting, scanning 82 %, 91 %, and 95 % of CTCs in ALK-, ROS1-, and ERG-rearranged patients respectively. A multi-exposure protocol consisting of three separate exposure times for green and red fluorochromes was optimized to analyze the intensity, size and thickness of FISH signals. CONCLUSIONS: The semi-automated microscopy method reported here increases the feasibility and reliability of filtration-enriched CTC assays and can help progress towards their validation and translation to the clinic.

Is isolated insert exchange a valuable choice for polyethylene wear in metal-backed unicompartmental knee arthroplasty?

PURPOSE: The aim of this study was to evaluate the clinical outcome and survival rate after isolated liner exchange for polyethylene (PE) wear in well-fixed metal-backed fixed-bearing unicompartmental knee arthroplasty (UKA). METHODS: Twenty medial UKAs in 19 patients [mean age 68.7 years ± 8.7 (range 48.5-81.5 years)] operated on for a direct PE liner exchange after isolated PE wear between 1996 and 2010 in two institutions were retrospectively reviewed. The mean delay between the index operation and revision was 8.2 years ± 2.6 (range 4.8-12.8 years). A four-level satisfaction questionnaire was used, and clinical outcomes were assessed using Knee Society scores (KSS) and range of motion (ROM) evaluation. Radiological evaluation analysed the position of the implants and progression of the disease. Survival rate of the implants was evaluated using Kaplan-Meier analysis with two different end-points. RESULTS: At the last follow-up [mean 6.8 years ± 5.2 (range 1.1-15.9 years)], 15 patients (79 %) were enthusiastic or satisfied. KSS improved from 73.4 to 86.4 points (p = 0.01) and function from 58.9 to 89.2 points (p < 0.001). ROM at last FU was 126.5° ± 10.3°. The survival rate at 12 years considering "revision for any reason" as the end-point was 71.3 ± 15.3 %, and the survival rate at 12 years considering "revision of UKA to TKA" as the end-point was 93.3 ± 6.4 %. CONCLUSION: Isolated liner exchange for PE wear in well-fixed metal-backed fixed-bearing UKA represents a valuable treatment option in selective patients with durable improvement of clinical outcomes without compromising any future revision. LEVEL OF EVIDENCE: Retrospective therapeutic study, Level IV.

Are titanium-on-titanium TiAl6V4 modular necks safe in total hip arthroplasty for non-overweight patients? Results of a prospective series at a minimum follow-up of 7 years.

Using extramedullar modularity in total hip arthroplasty has been proposed as an option to optimize the restoration of hip biomechanics. To avoid the problems that were observed with cobalt-chrome modular neck, titanium modular necks have been developed. The goals of our study were to evaluate the safety of titanium-on-titanium TiAl6V4 modular neck system. Hundred patients with a mean age of 69.6 ± 10.6 (42-86 years) and mean BMI of 25.07 ± 4.86 (17-38 kg/m(2)) suffering from primary or secondary arthritis of the hip were prospectively included. At a minimum of 7 years, no fracture of the modular neck was observed. No patient required a revision. No sign of loosening was found in the radiological analysis. Our study shows that titanium-on-titanium TiAl6V4 modular neck system can safely be used with good midterm clinical and radiological results for non-overweight patients. These results should be confirmed at longer follow-up.

A bullet in the supraspinatus compartment successfully removed by arthroscopy: case report and review of the literature.

Arthroscopic removal of bullet from intra-articular compartment has been described for several joints. Only few reports dealing with this condition in the shoulder have been reported especially for the glenohumeral and the subacromial compartments. We report the story of a fifty-seven-year-old man presenting a bullet in the supraspinatus compartment of his left shoulder successfully removed by arthroscopy.

Does surface roughness influence the primary stability of acetabular cups? A numerical and experimental biomechanical evaluation.

Most acetabular cups implanted today are press-fit impacted cementless. Anchorage begins with the primary stability given by insertion of a slightly oversized cup. This primary stability is key to obtaining bone ingrowth and secondary stability. We tested the hypothesis that primary stability of the cup is related to surface roughness of the implant, using both an experimental and a numerical models to analyze how three levels of surface roughness (micro, macro and combined) affect the primary stability of the cup. We also investigated the effect of differences in diameter between the cup and its substrate, and of insertion force, on the cups' primary stability. The results of our study show that primary stability depends on the surface roughness of the cup. The presence of macro-roughness on the peripheral ring is found to decrease primary stability; there was excessive abrasion of the substrate, damaging it and leading to poor primary stability. Numerical modeling indicates that oversizing the cup compared to its substrate has an impact on primary stability, as has insertion force.

Pullout strength of all suture anchors in the repair of rotator cuff tears: a biomechanical study.

PURPOSE: We evaluated the biomechanical strength of two all suture anchors (ASA) of reduced diameter (1.4 mm) and compared them with the standard screw anchor (SA) with larger diameter (5.5 mm) used in rotator cuff tears. METHODS: We conducted 30 uniaxial vertical pullout tests using Material Testing System Instron 5566A until failure of the anchorage defined as rupture of the threads or anchor or detachment of the anchor. Anchor fixation was on tuberosities of fresh bovine humerus bone. ASAs were spaced four millimetres apart and were compared with a control SA implanted on the same greater tubercle at two centimetres. The tests were all performed at room temperature in a dry environment. Tensile loads (10 mm/min) were applied parallel to the axis of insertion. A preloading of 10 N was used to overcome loading artifacts of the test sample at the beginning of the test. RESULTS: Student's t test showed no statistically significant difference between anchors in terms of load to failure (ASA: force 265.06 ± 87.25 N versus SA : 325.35 ± 113.46 N; p = 0.09) and mean elongation at rupture (ASA : 23 ± 7 mm versus SA : 21 ± 6 mm; p = 0.46). CONCLUSIONS: In vitro, this experimental study showed no statistically significant difference in pullout strength and displacement between ASA and SA at a chosen level of significance (p < 0.05).