[The effect of experimental hepatopathy on the nature of the spontaneous metastasis of Lewis lung carcinoma]. / Vliianie éksperimental'noi gepatopatii na kharakter spontannogo metastazirovaniia kartsinomy legkikh L'iuis.

The paper deals with the effect of carbon tetrachloride-induced hepatopathy on pattern of spontaneous dissemination of Lewis tumor transplanted to C57B1/6 mice. Antitumor drugs vincristine and rubomycin prevented dissemination to the liver but failed to arrest spreading to the lung.

[The growth and metastatic characteristics of Lewis lung carcinoma during reproductive dysfunction in male C57BL/6 mice]. / Kharakteristika rosta i metastazirovaniia kartsinomy legkogo L'iuis v usloviiakh disfunktsii reproduktivnoi sistemy myshei samtsov B57BL/6.

Results of a study of the pattern of spontaneous dissemination of Lewis lung carcinoma in male mice with reproductive system dysfunction showed that removal of the gonads followed by substitution treatment with testosterone failed to influence tumor metastatic potential. The data suggested that the androgen lacked a modulating effect on growth and dissemination of Lewis lung carcinoma.

[Effects of prospidin on the development of pulmonary metastases of Lewis tumors in rats in regard to changes in the level of extracellular calcium]. / Vliianie prospidina na razvitie legochnykh metastazov opukholi L'iuis na fone izmeneniia urovnia vnekletochnogo kal'tsiia.

The effect of prospidin on Lewis lung carcinoma spreading under hyper- and hypocalcemia was studied. At early stages, increased extracellular calcium level was associated with inhibition of tumor dissemination to the lungs; however, later, colony growth was stimulated. Extracellular calcium level was shown to modulate the antitumor and antimetastatic effect of prospidin.