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1.
Diagnostics (Basel) ; 14(15)2024 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-39125499

RESUMO

Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases in the world and poses a significant public health challenge. Early detection and management of this metabolic disorder is crucial to prevent complications and improve outcomes. This paper aims to find core differences in male and female markers to detect T2DM by their clinic and anthropometric features, seeking out ranges in potential biomarkers identified to provide useful information as a pre-diagnostic tool whie excluding glucose-related biomarkers using machine learning (ML) models. We used a dataset containing clinical and anthropometric variables from patients diagnosed with T2DM and patients without TD2M as control. We applied feature selection with three different techniques to identify relevant biomarker models: an improved recursive feature elimination (RFE) evaluating each set from all the features to one feature with the Akaike information criterion (AIC) to find optimal outputs; Least Absolute Shrinkage and Selection Operator (LASSO) with glmnet; and Genetic Algorithms (GA) with GALGO and forward selection (FS) applied to GALGO output. We then used these for comparison with the AIC to measure the performance of each technique and collect the optimal set of global features. Then, an implementation and comparison of five different ML models was carried out to identify the most accurate and interpretable one, considering the following models: logistic regression (LR), artificial neural network (ANN), support vector machine (SVM), k-nearest neighbors (KNN), and nearest centroid (Nearcent). The models were then combined in an ensemble to provide a more robust approximation. The results showed that potential biomarkers such as systolic blood pressure (SBP) and triglycerides are together significantly associated with T2DM. This approach also identified triglycerides, cholesterol, and diastolic blood pressure as biomarkers with differences between male and female actors that have not been previously reported in the literature. The most accurate ML model was selection with RFE and random forest (RF) as the estimator improved with the AIC, which achieved an accuracy of 0.8820. In conclusion, this study demonstrates the potential of ML models in identifying potential biomarkers for early detection of T2DM, excluding glucose-related biomarkers as well as differences between male and female anthropometric and clinic profiles. These findings may help to improve early detection and management of the T2DM by accounting for differences between male and female subjects in terms of anthropometric and clinic profiles, potentially reducing healthcare costs and improving personalized patient attention. Further research is needed to validate these potential biomarkers ranges in other populations and clinical settings.

2.
Diseases ; 11(4)2023 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-37873778

RESUMO

The escalating prevalence of Type 2 Diabetes (T2D) represents a substantial burden on global healthcare systems, especially in regions such as Mexico. Existing diagnostic techniques, although effective, often require invasive procedures and labor-intensive efforts. The promise of artificial intelligence and data science for streamlining and enhancing T2D diagnosis is well-recognized; however, these advancements are frequently constrained by the limited availability of comprehensive patient datasets. To mitigate this challenge, the present study investigated the efficacy of Generative Adversarial Networks (GANs) for augmenting existing T2D patient data, with a focus on a Mexican cohort. The researchers utilized a dataset of 1019 Mexican nationals, divided into 499 non-diabetic controls and 520 diabetic cases. GANs were applied to create synthetic patient profiles, which were subsequently used to train a Random Forest (RF) classification model. The study's findings revealed a notable improvement in the model's diagnostic accuracy, validating the utility of GAN-based data augmentation in a clinical context. The results bear significant implications for enhancing the robustness and reliability of Machine Learning tools in T2D diagnosis and management, offering a pathway toward more timely and effective patient care.

3.
Sensors (Basel) ; 23(17)2023 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-37688015

RESUMO

In recent years, the application of artificial intelligence (AI) in the automotive industry has led to the development of intelligent systems focused on road safety, aiming to improve protection for drivers and pedestrians worldwide to reduce the number of accidents yearly. One of the most critical functions of these systems is pedestrian detection, as it is crucial for the safety of everyone involved in road traffic. However, pedestrian detection goes beyond the front of the vehicle; it is also essential to consider the vehicle's rear since pedestrian collisions occur when the car is in reverse drive. To contribute to the solution of this problem, this research proposes a model based on convolutional neural networks (CNN) using a proposed one-dimensional architecture and the Inception V3 architecture to fuse the information from the backup camera and the distance measured by the ultrasonic sensors, to detect pedestrians when the vehicle is reversing. In addition, specific data collection was performed to build a database for the research. The proposed model showed outstanding results with 99.85% accuracy and 99.86% correct classification performance, demonstrating that it is possible to achieve the goal of pedestrian detection using CNN by fusing two types of data.

4.
J Diabetes Res ; 2023: 9713905, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37404324

RESUMO

The development of medical diagnostic models to support healthcare professionals has witnessed remarkable growth in recent years. Among the prevalent health conditions affecting the global population, diabetes stands out as a significant concern. In the domain of diabetes diagnosis, machine learning algorithms have been widely explored for generating disease detection models, leveraging diverse datasets primarily derived from clinical studies. The performance of these models heavily relies on the selection of the classifier algorithm and the quality of the dataset. Therefore, optimizing the input data by selecting relevant features becomes essential for accurate classification. This research presents a comprehensive investigation into diabetes detection models by integrating two feature selection techniques: the Akaike information criterion and genetic algorithms. These techniques are combined with six prominent classifier algorithms, including support vector machine, random forest, k-nearest neighbor, gradient boosting, extra trees, and naive Bayes. By leveraging clinical and paraclinical features, the generated models are evaluated and compared to existing approaches. The results demonstrate superior performance, surpassing accuracies of 94%. Furthermore, the use of feature selection techniques allows for working with a reduced dataset. The significance of feature selection is underscored in this study, showcasing its pivotal role in enhancing the performance of diabetes detection models. By judiciously selecting relevant features, this approach contributes to the advancement of medical diagnostic capabilities and empowers healthcare professionals in making informed decisions regarding diabetes diagnosis and treatment.


Assuntos
Algoritmos , Diabetes Mellitus , Humanos , Teorema de Bayes , Aprendizado de Máquina , Diabetes Mellitus/diagnóstico , Algoritmo Florestas Aleatórias
5.
Sensors (Basel) ; 23(2)2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36679580

RESUMO

Driver identification refers to the process whose primary purpose is identifying the person behind the steering wheel using collected information about the driver him/herself. The constant monitoring of drivers through sensors generates great benefits in advanced driver assistance systems (ADAS), to learn more about the behavior of road users. Currently, there are many research works that address the subject in search of creating intelligent models that help to identify vehicle users in an efficient and objective way. However, the different methodologies proposed to create these models are based on data generated from sensors that include different vehicle brands on routes established in real environments, which, although they provide very important information for different purposes, in the case of driver identification, there may be a certain degree of bias due to the different situations in which the route environment may change. The proposed method seeks to intelligently and objectively select the most outstanding statistical features from motor activity generated in the main elements of the vehicle with genetic algorithms for driver identification, this process being newer than those established by the state-of-the-art. The results obtained from the proposal were an accuracy of 90.74% to identify two drivers and 62% for four, using a Random Forest Classifier (RFC). With this, it can be concluded that a comprehensive selection of features can greatly optimize the identification of drivers.


Assuntos
Condução de Veículo , Humanos , Masculino , Acidentes de Trânsito , Algoritmo Florestas Aleatórias , Aprendizagem , Atividade Motora
6.
Rev. mex. ing. bioméd ; 44(spe1): 38-52, Aug. 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1565605

RESUMO

Abstract It is estimated that depression affects more than 300 million people in worldwide. Unfortunately, the current method of psychiatric evaluation requires a great effort on the part of clinicians to collect complete information. The aim of this paper is determine the optimal time intervals to detect depression using genetic algorithms and machine learning techniques; from motor activity readings of 55 participants during a week at one-minute intervals. The time intervals with the best performance in detecting depression in individuals were selected by applying Genetic Algorithms (GA). Methodology. 385 observations of the study participants were evaluated, obtaining an accuracy of 83.0 % with Logistic Regression (LR). Conclusion. There is a relationship between motor activity and people with depression since it is possible to detect it using machine learning techniques. However, the changes in the variables of the time intervals could be established as key factors since, at different times, they could give good or bad results because the motor activity in the patients could vary. However, the results present a first approximation for developing tools that help the opportune and objective diagnosis of depression.


Resumen Se estima que la depresión afecta a más de 300 millones de personas en el mundo. Desafortunadamente, el método de evaluación psiquiátrica actual requiere un gran esfuerzo por parte de los médicos para recopilar información completa. Objetivo. Determinar los intervalos de tiempo óptimos para detectar depresión mediante algoritmos genéticos y técnicas de aprendizaje automático, a partir de las lecturas de actividad motora de 55 sujetos durante una semana en intervalos de un minuto. Los intervalos de tiempo con mejor desempeño en la detección de depresión en individuos fueron seleccionados aplicando algoritmos genéticos. Metodología. Se evaluaron 385 observaciones de los sujetos de estudio, obteniendo una precisión del 83.0 % con Regresión Logística (LR). Conclusión. Existe una relación entre la actividad motora y las personas con depresión ya que es posible detectarla utilizando técnicas de aprendizaje automático. Sin embargo, los cambios en las variables de los intervalos de tiempo podrían establecerse como factores clave ya que en diferentes momentos podrían dar buenos o malos resultados debido a que la actividad motora en los pacientes podría llegar a variar. No obstante, los resultados presentan una primera aproximación para el desarrollo de herramientas que ayuden al diagnóstico oportuno y objetivo de la depresión.

7.
Diagnostics (Basel) ; 12(12)2022 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-36553106

RESUMO

Breast cancer is the most common cancer among women worldwide, after lung cancer. However, early detection of breast cancer can help to reduce death rates in breast cancer patients and also prevent cancer from spreading to other parts of the body. This work proposes a new method to design a bio-marker integrating Bayesian predictive models, pyRadiomics System and genetic algorithms to classify the benign and malignant lesions. The method allows one to evaluate two types of images: The radiologist-segmented lesion, and a novel automated breast cancer detection by the analysis of the whole breast. The results demonstrate only a difference of 12% of effectiveness for the cases of calcification between the radiologist generated segmentation and the automatic whole breast analysis, and a 25% of difference between the lesion and the breast for the cases of masses. In addition, our approach was compared against other proposed methods in the literature, providing an AUC = 0.86 for the analysis of images with lesions in breast calcification, and AUC = 0.96 for masses.

8.
Rev Invest Clin ; 74(6): 314-327, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36546894

RESUMO

Background: The coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus and is responsible for nearly 6 million deaths worldwide in the past 2 years. Machine learning (ML) models could help physicians in identifying high-risk individuals. Objectives: To study the use of ML models for COVID-19 prediction outcomes using clinical data and a combination of clinical and metabolic data, measured in a metabolomics facility from a public university. Methods: A total of 154 patients were included in the study. "Basic profile" was considered with clinical and demographic variables (33 variables), whereas in the "extended profile," metabolomic and immunological variables were also considered (156 characteristics). A selection of features was carried out for each of the profiles with a genetic algorithm (GA) and random forest models were trained and tested to predict each of the stages of COVID-19. Results: The model based on extended profile was more useful in early stages of the disease. Models based on clinical data were preferred for predicting severe and critical illness and death. ML detected trimethylamine N-oxide, lipid mediators, and neutrophil/lymphocyte ratio as important variables. Conclusions: ML and GAs provided adequate models to predict COVID-19 outcomes in patients with different severity grades.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , COVID-19/diagnóstico , Algoritmos , Prognóstico , Aprendizado de Máquina
9.
Rev. invest. clín ; Rev. invest. clín;74(6): 314-327, Nov.-Dec. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1431820

RESUMO

ABSTRACT Background: The coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus and is responsible for nearly 6 million deaths worldwide in the past 2 years. Machine learning (ML) models could help physicians in identifying high-risk individuals. Objectives: To study the use of ML models for COVID-19 prediction outcomes using clinical data and a combination of clinical and metabolic data, measured in a metabolomics facility from a public university. Methods: A total of 154 patients were included in the study. "Basic profile" was considered with clinical and demographic variables (33 variables), whereas in the "extended profile," metabolomic and immunological variables were also considered (156 characteristics). A selection of features was carried out for each of the profiles with a genetic algorithm (GA) and random forest models were trained and tested to predict each of the stages of COVID-19. Results: The model based on extended profile was more useful in early stages of the disease. Models based on clinical data were preferred for predicting severe and critical illness and death. ML detected trimethylamine N-oxide, lipid mediators, and neutrophil/lymphocyte ratio as important variables. Conclusion: ML and GAs provided adequate models to predict COVID-19 outcomes in patients with different severity grades.

10.
Diagnostics (Basel) ; 12(11)2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36428864

RESUMO

According to the World Health Organization (WHO), type 2 diabetes mellitus (T2DM) is a result of the inefficient use of insulin by the body. More than 95% of people with diabetes have T2DM, which is largely due to excess weight and physical inactivity. This study proposes an intelligent feature selection of metabolites related to different stages of diabetes, with the use of genetic algorithms (GA) and the implementation of support vector machines (SVMs), K-Nearest Neighbors (KNNs) and Nearest Centroid (NEARCENT) and with a dataset obtained from the Instituto Mexicano del Seguro Social with the protocol name of the following: "Análisis metabolómico y transcriptómico diferencial en orina y suero de pacientes pre diabéticos, diabéticos y con nefropatía diabética para identificar potenciales biomarcadores pronósticos de daño renal" (differential metabolomic and transcriptomic analyses in the urine and serum of pre-diabetic, diabetic and diabetic nephropathy patients to identify potential prognostic biomarkers of kidney damage). In order to analyze which machine learning (ML) model is the most optimal for classifying patients with some stage of T2DM, the novelty of this work is to provide a genetic algorithm approach that detects significant metabolites in each stage of progression. More than 100 metabolites were identified as significant between all stages; with the data analyzed, the average accuracies obtained in each of the five most-accurate implementations of genetic algorithms were in the range of 0.8214-0.9893 with respect to average accuracy, providing a precise tool to use in detections and backing up a diagnosis constructed entirely with metabolomics. By providing five potential biomarkers for progression, these extremely significant metabolites are as follows: "Cer(d18:1/24:1) i2", "PC(20:3-OH/P-18:1)", "Ganoderic acid C2", "TG(16:0/17:1/18:1)" and "GPEtn(18:0/20:4)".

11.
Pathogens ; 11(10)2022 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-36297185

RESUMO

The aim of this study was to analyze molecules associated with regulatory immune response in unvaccinated, recovered COVID-19 patients with and without diabetes mellitus (DM) and hypertension (HTN). We determined anti-SARS-CoV-2 nucleocapsid IgG in plasma by electrochemiluminescence immunoassay. The levels of sCD40, TGF-ß, IL-10, and sCTLA-4 were assessed by ELISA in the serum of the subjects, as well as in healthy donors. We observed that only half of the subjects in the non-comorbid group produced antibodies, whereas all subjects in comorbid groups were IgG-positive for the anti-SARS-CoV-2 nucleocapsid. High levels of sCTL-4 were observed in the non-comorbid group, and the level of IL-10 was observed to increase in seropositive subjects without comorbidities. TGF-ß concentration was similar in all groups studied. Finally, sCD40 decreased in the comorbid group. In conclusion, our results suggest that comorbidities such as DM and HTN alter the production of co-stimulatory inhibitory molecules sCTLA-4 and sCD40 in subjects recovering from mild COVID-19. The alterations observed here were independent of seropositivity, suggesting an effective humoral immune response against COVID-19 separate from the levels of co-stimulatory inhibitory molecules.

12.
Bioengineering (Basel) ; 9(9)2022 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-36135004

RESUMO

Depression is a common illness worldwide, affecting an estimated 3.8% of the population, including 5% of all adults, in particular, 5.7% of adults over 60 years of age. Unfortunately, at present, the ways to evaluate different mental disorders, like the Montgomery-Åsberg depression rating scale (MADRS) and observations, need a great effort, on part of specialists due to the lack of availability of patients to obtain the necessary information to know their conditions and to detect illness such as depression in an objective way. Based on data analysis and artificial intelligence techniques, like Convolutional Neural Network (CNN), it is possible to classify a person, from the mental status examination, into two classes. Moreover, it is beneficial to observe how the data of these two classes are similar in different time intervals. In this study, a motor activity database was used, from which the readings of 55 subjects of study (32 healthy and 23 with some degree of depression) were recorded with a small wrist-worn accelerometer to detect the peak amplitude of movement acceleration and generate a transient voltage signal proportional to the rate of acceleration. Motor activity data were selected per patient in time-lapses of one day for seven days (one week) in one-minute intervals. The data were pre-processed to be given to a two-dimensional convolutional network (2D-CNN), where each record of motor activity per minute was represented as a pixel of an image. The proposed model is capable of detecting depression in real-time (if this is implemented in a mobile device such as a smartwatch) with low computational cost and accuracy of 76.72% In summary, the model shows promising abilities to detect possible cases of depression, providing a helpful resource to identify the condition and be able to take the appropriate follow-up for the patient.

13.
Healthcare (Basel) ; 10(8)2022 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-35893185

RESUMO

Type 2 diabetes mellitus (T2DM) represents one of the biggest health problems in Mexico, and it is extremely important to early detect this disease and its complications. For a noninvasive detection of T2DM, a machine learning (ML) approach that uses ensemble classification models with dichotomous output that is also fast and effective for early detection and prediction of T2D can be used. In this article, an ensemble technique by hard voting is designed and implemented using generalized linear regression (GLM), support vector machines (SVM) and artificial neural networks (ANN) for the classification of T2DM patients. In the materials and methods as a first step, the data is balanced, standardized, imputed and integrated into the three models to classify the patients in a dichotomous result. For the selection of features, an implementation of LASSO is developed, with a 10-fold cross-validation and for the final validation, the Area Under the Curve (AUC) is used. The results in LASSO showed 12 features, which are used in the implemented models to obtain the best possible scenario in the developed ensemble model. The algorithm with the best performance of the three is SVM, this model obtained an AUC of 92% ± 3%. The ensemble model built with GLM, SVM and ANN obtained an AUC of 90% ± 3%.

14.
Healthcare (Basel) ; 10(7)2022 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-35885784

RESUMO

Major depressive disorder (MDD) is the most recurrent mental illness globally, affecting approximately 5% of adults. Furthermore, according to the National Institute of Mental Health (NIMH) of the U.S., calculating an actual schizophrenia prevalence rate is challenging because of this illness's underdiagnosis. Still, most current global metrics hover between 0.33% and 0.75%. Machine-learning scientists use data from diverse sources to analyze, classify, or predict to improve the psychiatric attention, diagnosis, and treatment of MDD, schizophrenia, and other psychiatric conditions. Motor activity data are gaining popularity in mental illness diagnosis assistance because they are a cost-effective and noninvasive method. In the knowledge discovery in databases (KDD) framework, a model to classify depressive and schizophrenic patients from healthy controls is constructed using accelerometer data. Taking advantage of the multiple sleep disorders caused by mental disorders, the main objective is to increase the model's accuracy by employing only data from night-time activity. To compare the classification between the stages of the day and improve the accuracy of the classification, the total activity signal was cut into hourly time lapses and then grouped into subdatasets depending on the phases of the day: morning (06:00-11:59), afternoon (12:00-17:59), evening (18:00-23:59), and night (00:00-05:59). Random forest classifier (RFC) is the algorithm proposed for multiclass classification, and it uses accuracy, recall, precision, the Matthews correlation coefficient, and F1 score to measure its efficiency. The best model was night-featured data and RFC, with 98% accuracy for the classification of three classes. The effectiveness of this experiment leads to less monitoring time for patients, reducing stress and anxiety, producing more efficient models, using wearables, and increasing the amount of data.

15.
Healthcare (Basel) ; 10(7)2022 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-35885829

RESUMO

Sudden infant death syndrome (SIDS) represents the leading cause of death in under one year of age in developing countries. Even in our century, its etiology is not clear, and there is no biomarker that is discriminative enough to predict the risk of suffering from it. Therefore, in this work, taking a public dataset on the lipidomic profile of babies who died from this syndrome compared to a control group, a univariate analysis was performed using the Mann-Whitney U test, with the aim of identifying the characteristics that enable discriminating between both groups. Those characteristics with a p-value less than or equal to 0.05 were taken; once these characteristics were obtained, classification models were implemented (random forests (RF), logistic regression (LR), support vector machine (SVM) and naive Bayes (NB)). We used seventy percent of the data for model training, subjecting it to a cross-validation (k = 5) and later submitting to validation in a blind test with 30% of the remaining data, which allows simulating the scenario in real life-that is, with an unknown population for the model. The model with the best performance was RF, since in the blind test, it obtained an AUC of 0.9, specificity of 1, and sensitivity of 0.8. The proposed model provides the basis for the construction of a SIDS risk prediction computer tool, which will contribute to prevention, and proposes lines of research to deal with this pathology.

16.
Sensors (Basel) ; 22(11)2022 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-35684825

RESUMO

Automatic identification of human facial expressions has many potential applications in today's connected world, from mental health monitoring to feedback for onscreen content or shop windows and sign-language prosodic identification. In this work we use visual information as input, namely, a dataset of face points delivered by a Kinect device. The most recent work on facial expression recognition uses Machine Learning techniques, to use a modular data-driven path of development instead of using human-invented ad hoc rules. In this paper, we present a Machine-Learning based method for automatic facial expression recognition that leverages information fusion architecture techniques from our previous work and soft voting. Our approach shows an average prediction performance clearly above the best state-of-the-art results for the dataset considered. These results provide further evidence of the usefulness of information fusion architectures rather than adopting the default ML approach of features aggregation.


Assuntos
Reconhecimento Facial , Face , Expressão Facial , Humanos , Aprendizado de Máquina , Política
17.
J Pers Med ; 11(12)2021 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-34945799

RESUMO

One of the main microvascular complications presented in the Mexican population is diabetic retinopathy which affects 27.50% of individuals with type 2 diabetes. Therefore, the purpose of this study is to construct a predictive model to find out the risk factors of this complication. The dataset contained a total of 298 subjects, including clinical and paraclinical features. An analysis was constructed using machine learning techniques including Boruta as a feature selection method, and random forest as classification algorithm. The model was evaluated through a statistical test based on sensitivity, specificity, area under the curve (AUC), and receiving operating characteristic (ROC) curve. The results present significant values obtained by the model obtaining 69% of AUC. Moreover, a risk evaluation was incorporated to evaluate the impact of the predictors. The proposed method identifies creatinine, lipid treatment, glomerular filtration rate, waist hip ratio, total cholesterol, and high density lipoprotein as risk factors in Mexican subjects. The odds ratio increases by 3.5916 times for control patients which have high levels of cholesterol. It is possible to conclude that this proposed methodology is a preliminary computer-aided diagnosis tool for clinical decision-helping to identify the diagnosis of DR.

18.
Diagnostics (Basel) ; 11(12)2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34943434

RESUMO

Differences in clinical manifestations, immune response, metabolic alterations, and outcomes (including disease severity and mortality) between men and women with COVID-19 have been reported since the pandemic outbreak, making it necessary to implement sex-specific biomarkers for disease diagnosis and treatment. This study aimed to identify sex-associated differences in COVID-19 patients by means of a genetic algorithm (GALGO) and machine learning, employing support vector machine (SVM) and logistic regression (LR) for the data analysis. Both algorithms identified kynurenine and hemoglobin as the most important variables to distinguish between men and women with COVID-19. LR and SVM identified C10:1, cough, and lysoPC a 14:0 to discriminate between men with COVID-19 from men without, with LR being the best model. In the case of women with COVID-19 vs. women without, SVM had a higher performance, and both models identified a higher number of variables, including 10:2, lysoPC a C26:0, lysoPC a C28:0, alpha-ketoglutaric acid, lactic acid, cough, fever, anosmia, and dysgeusia. Our results demonstrate that differences in sexes have implications in the diagnosis and outcome of the disease. Further, genetic and machine learning algorithms are useful tools to predict sex-associated differences in COVID-19.

19.
Sensors (Basel) ; 21(22)2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34833826

RESUMO

Worldwide, motor vehicle accidents are one of the leading causes of death, with alcohol-related accidents playing a significant role, particularly in child death. Aiming to aid in the prevention of this type of accidents, a novel non-invasive method capable of detecting the presence of alcohol inside a motor vehicle is presented. The proposed methodology uses a series of low-cost alcohol MQ3 sensors located inside the vehicle, whose signals are stored, standardized, time-adjusted, and transformed into 5 s window samples. Statistical features are extracted from each sample and a feature selection strategy is carried out using a genetic algorithm, and a forward selection and backwards elimination methodology. The four features derived from this process were used to construct an SVM classification model that detects presence of alcohol. The experiments yielded 7200 samples, 80% of which were used to train the model. The rest were used to evaluate the performance of the model, which obtained an area under the ROC curve of 0.98 and a sensitivity of 0.979. These results suggest that the proposed methodology can be used to detect the presence of alcohol and enforce prevention actions.


Assuntos
Condução de Veículo , Dirigir sob a Influência , Acidentes de Trânsito/prevenção & controle , Algoritmos , Criança , Humanos , Veículos Automotores
20.
Healthcare (Basel) ; 9(7)2021 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-34356262

RESUMO

Children's healthcare is a relevant issue, especially the prevention of domestic accidents, since it has even been defined as a global health problem. Children's activity classification generally uses sensors embedded in children's clothing, which can lead to erroneous measurements for possible damage or mishandling. Having a non-invasive data source for a children's activity classification model provides reliability to the monitoring system where it is applied. This work proposes the use of environmental sound as a data source for the generation of children's activity classification models, implementing feature selection methods and classification techniques based on Bayesian networks, focused on the recognition of potentially triggering activities of domestic accidents, applicable in child monitoring systems. Two feature selection techniques were used: the Akaike criterion and genetic algorithms. Likewise, models were generated using three classifiers: naive Bayes, semi-naive Bayes and tree-augmented naive Bayes. The generated models, combining the methods of feature selection and the classifiers used, present accuracy of greater than 97% for most of them, with which we can conclude the efficiency of the proposal of the present work in the recognition of potentially detonating activities of domestic accidents.

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