Queratitis de etiología inusual en paciente con queratopatía bullosa / Unusual aetiology of keratitis in a patient with bullous keratopath

No disponible

Meningitis neonatal por Enterococcus faecalis / Neonatal meningitis due to Enterococcus faecalis

La meningitis por enterococo es una entidad clínica muy poco frecuente, representando el 0,3-4% de las meningitis bacterianas y siendo Enterococcus faecalis (E. faecalis) la especie aislada más común. Existen factores de riesgo para su desarrollo en recién nacidos, como fiebre materna intraparto, corioamnionitis, prematuridad o resección intestinal previa. Nuestro objetivo es describir un caso de meningitis asociada a sepsis precoz causada por E. faecalis en un recién nacido que presentó fiebre, irritabilidad y mal estado general a las 24 h de nacer, coincidiendo con un examen de líquido cefalorraquídeo que mostró parámetros citoquímicos normales. Como antecedente de interés destaca fiebre materna intraparto. Los hallazgos clínicos y analíticos sugirieron un proceso infeccioso, que se confirmó con el aislamiento de E. faecalis en líquido cefalorraquídeo. La evolución de la paciente fue favorable tras tratamiento con ampicilina y gentamicina. El antecedente epidemiológico hizo suponer una transmisión vertical

Enterococcal meningitis is a very rare clinical entity, accounting for 0.3-4% of bacterial meningitis, with Enterococcus faecalis (E. faecalis) being the most common isolated species. There are risk factors for its development in newborns, such as maternal intrapartum fever, chorioamnionitis, prematurity, or previous intestinal resection. The aim of this article is to describe a case of meningitis associated with early sepsis caused by E. faecalis in a newborn with fever, irritability, and in a poor general condition at 24hours of birth, coinciding with normal cytochemical parameters in cerebrospinal fluid. The clinical and analytical findings suggested an infectious process, which was confirmed by the isolation of E. faecalis in cerebrospinal fluid. The patient outcome was favourable after treatment with ampicillin and gentamicin. The epidemiological history suggested a vertical transmission

Absceso tubo-ovárico por Eikenella corrodens / Tuboovarian abscess due to Eikenella corrodens

No disponible

Otitis externa por Turicella otitidis: a propósito de dos casos / No disponible

No disponible

Bacteriemia por Campylobacter coli asociada a inmunosupresión / Campylobacter coli bacteremia linked immunosuppression

La infección por Campylobacter spp. constituye una de las principales causas de enteritis bacteriana en los seres humanos. Mientras que Campylobacter fetus puede causar infecciones sistémicas tales como celulitis, osteomielitis, artritis, pericarditis y endocarditis, Campylobacter coli y Campylobacter jejuni producen por lo general infecciones gastrointestinales y raramente bacteriemia, excepto en individuos de edad avanzada o inmunodeprimidos. A continuación, exponemos el caso de un varón de 26 años afectado por la inmunodeficiencia XLA, que presentó un cuadro de fiebre de 2 semanas de evolución, con dolor e inflamación en el tobillo izquierdo postintervención quirúrgica y 5-6 deposiciones diarias de heces líquidas. La exploración y la analítica inicial evidenciaron un proceso infeccioso. Se procedió a la realización de coprocultivo y hemocultivo, constatándose bacteriemia por Campylobacter coli (AU)

Campylobacter spp. infection is considered as main bacterial enteritis causes in humans. Among Campylobacter spp., Campylobacter fetus can be a cause of systemic infections such as cellulitis, osteomyelitis, arthritis, pericarditis and endocarditis. However, Campylobacter coli and Campylobacter jejuni predominantly induce gastrointestinal infections and rarely cause bacteremia except in elderly and immunodeficient individuals. The case is presented of a 26 year-old male affected by XLA immunodeficiency, who had a clinical profile of 2 weeks evolution with fever, ankle left postintervention surgical and 5-6 daily liquid bowel movements without pathological products. Initial exploration and analytical showed an infectious process. We proceeded to carry out complementary, stool culture and blood culture tests where it was found Campylobacter coli bacteremia (AU)

[Activity of vancomycin, teicoplanin and linezolid in methicillin resistant coagulase-negative Staphylococci isolates from paediatric blood cultures]. / Actividad de vancomicina, teicoplanina y linezolid en Staphylococcus coagulasa-negativos resistentes a meticilina en aislados de hemocultivos pediátricos.

INTRODUCTION: Coagulase-negative-Staphylococci (CNS) are the major cause of bacteraemia and sepsis in newborns. CNS methicillin resistance and its loss of sensitivity to glycopeptide antibiotics, make treatment significantly more difficult in positive cocci infections. OBJECTIVE: To study MIC vancomycin, teicoplanin and linezolid in different species of CNS methicillin resistant isolates from blood cultures from paediatric patients. METHODS: Clinically relevant CNS methicillin resistant isolates from paediatric blood cultures from different hospitalization wards were tested. The isolates were identified by biochemical tests by means in the Combo panels 31 of MicroScan (Dade Behring, Siemens). Resistance to oxacillin and susceptibility to vancomycin, teicoplanin and linezolid were tested by microdilution panels as cited above. We also tested teicoplanin and linezolid sensitivity using Etest. RESULTS: 50 methicillin resistant strains were isolated: 37 (74%)S. epidermidis, 7 (14%) S. hominis, 4 (8%) S. haemolyticus and 2 (4%) Staphylococcus spp. 26 strains were observed with reduced susceptibility to vancomycin MIC = 2 mg/L, (22 S. epidermidis, 2 S. haemolyticus and 2 Staphylococcus spp.) and 21 strains with loss of susceptibility to teicoplanin, MIC = 4-16 mg/L (20 S. epidermidis and 1 S. haemolyticus). No CNS linezolid resistant was found. CONCLUSIONS: There is a linear correlation between increased vancomycin MIC and teicoplanin MIC. There is a statistically significant difference (p <0.001) in the MIC of teicoplanin in the vancomycin group = 2 mg/L with respect to the vancomycin group ≤ 1 mg/L. We also observed very low levels of linezolid MIC for all strains.

Actividad de vancomicina, teicoplanina y linezolid en Staphylococcus coagulasanegativos resistentes a meticilina en aislados de hemocultivos pediátricos / Activity of vancomycin, teicoplanin and linezolid in methicillin resistant coagulase-negative Staphylococci isolates from paediatric blood cultures

Introducción. Los Staphylococcus coagulasa negativos (ECN) son la principal causa de bacteriemia y sepsis en los recién nacidos. La resistencia meticilina y la pérdida de sensibilidad a glucopéptidos dificultan considerablemente el tratamiento antimicrobiano en infecciones por cocos grampositivos. Objetivos. Estudiar la CMI para vancomicina, teicoplanina y linezolid en diferentes especies de ECN meticilín resistentes aislados en hemocultivos procedentes de pacientes pediátricos. Métodos. Analizar los ECN resistentes a meticilina y clínicamente significativos, procedentes de hemocultivos de pacientes ingresados en diferentes Áreas del Servicio de Pediatría. Los aislamientos se identificaron mediante pruebas bioquímicas contenidas en los paneles Combo 31 de MicroScan (Dade Behring Siemens). La resistencia a oxacilina y la susceptibilidad frente a vancomicina, teicoplanina y linezolid se realizó mediante microdilución en placa contenida en los mismos paneles. Además se realizó Etest para teicoplanina y linezolid. Resultados. Se aislaron 50 cepas resistentes a meticilina: 37 (74%) S. epidermidis, 7 (14%) S. hominis, 4 (8%) S. haemolyticus y 2 (4%) Staphylococcus spp. Se observaron 26 cepas con sensibilidad disminuida para vancomicina, CMI de 2 mg/L, (22 S. epidermidis, 2 S. haemolyticus y 2 Staphylococcus spp.) y 21 cepas con disminución de sensibilidad a teicoplanina, CMI de 4-16 mg/L (20 S. epidermidis y 1 S. haemolyticus). Ningún ECN fue resistente a linezolid. Conclusiones. Existe una relación entre el aumento de CMI de vancomicina y el aumento de CMI de teicoplanina. Se observa una elevación estadísticamente significativa (p<0,001) en la CMI de teicoplanina en el grupo de vancomicina de 2 mg/L con respecto al grupo de vancomicina de ≤1 mg/L. Se observaron niveles muy bajos de CMI para linezolid en todas las cepas(AU)

Introduction. Coagulase-negative-Staphylococci (CNS) are the major cause of bacteraemia and sepsis in newborns. CNS methicillin resistance and its loss of sensitivity to glycopeptide antibiotics, make treatment significantly more difficult in positive cocci infections. Objective. To study MIC vancomycin, teicoplanin and linezolid in different species of CNS methicillin resistant isolates from blood cultures from paediatric patients. Methods. Clinically relevant CNS methicillin resistant isolates from paediatric blood cultures from different hospitalization wards were tested. The isolates were identified by biochemical tests by means in the Combo panels 31 of MicroScan (Dade Behring, Siemens). Resistance to oxacillin and susceptibility to vancomycin, teicoplanin and linezolid were tested by microdilution panels as cited above. We also tested teicoplanin and linezolid sensitivity using Etest. Results. 50 methicillin resistant strains were isolated: 37 (74%) S. epidermidis, 7 (14%) S. hominis, 4 (8%) S. haemolyticus and 2 (4%) Staphylococcus spp. 26 strains were observed with reduced susceptibility to vancomycin MIC = 2 mg/L, (22 S. epidermidis, 2 S. haemolyticus and 2 Staphylococcus spp.) and 21 strains with loss of susceptibility to teicoplanin, MIC = 4-16 mg/L (20 S. epidermidis and 1 S. haemolyticus). No CNS linezolid resistant was found. Conclusions. There is a linear correlation between increased vancomycin MIC and teicoplanin MIC. There is a statistically significant difference (p <0.001) in the MIC of teicoplanin in the vancomycin group = 2 mg/L with respect to the vancomycin group ≤ 1 mg/L. We also observed very low levels of linezolid MIC for all strains(AU)