RESUMO
Background. Maternal metabolic changes impact fetal metabolism resulting in a higher risk for developing chronic diseases later in life. The aim of this study was to assess the association between maternal and fetal adipokine and lipid profiles, as well as the influence of maternal weight on this association. Methods. Healthy pregnant women at term who delivered by C-section were enrolled. Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. Statistics included descriptives, correlations, and mean differences (SPSS v20.0). Results. Adiponectin and resistin concentrations were higher in fetal blood, while leptin was lower (p < 0.05). A significant inverse association between maternal resistin and fetal LDL-cholesterol (LDL-C) (r = -0.327; p = 0.022) was observed. A positive correlation was found between maternal and fetal resistin (r = 0.358; p = 0.013). Women with excessive weight gain had higher leptin levels and their fetuses showed higher LDL-C levels (p < 0.05). Conclusions. Maternal resistin showed an inverse association with fetal LDL-C, suggesting that maternal adiposity status may play an active role in the regulation of fetal lipid profile and consequently, in fetal programming. Excessive maternal weight gain during pregnancy may exert an effect over metabolic mediators in both mother and newborn.
RESUMO
El cáncer de ovario se origina de 3 tipos de células: células epiteliales, células germinales y células del estroma. Aproximadamente el 90% de los casos de cáncer de ovario son del tipo epitelial, que es la forma más frecuente de los 3 tipos histológicos y desafortunadamente una de las principales causas de muerte por cáncer del aparato reproductor femenino, al ser una enfermedad con sintomatología insidiosa e inespecífica, que lamentablemente tiene una mortalidad extremadamente alta. La incidencia de este tipo de estirpe aumenta con la edad, y a diferencia del de las células germinales y del estroma, son raros antes de los 40 años. Es importante saber que tanto en México como a nivel global, la variedad en incidencia del subtipo histológico del cáncer epitelial de ovario se da en las siguientes proporciones: seroso (60-80%), mucinoso (10-25%), endometrioide (8-20%), de células claras (5%), tumor de Brenner (< 1%) e indiferenciado. Esto nos muestra que el cáncer de ovario epitelial seroso es el más frecuente en el mundo, y por lo tanto, el que más asecha a las mujeres.
Ovarian cancer develops from three kinds of cells: epithelial cells, germ cells, and stromal cells. About 90% of ovarian cancer is of the epithelial kind, thus being the most frequent of the three histological types and, unfortunately, one of the main causes of death by female reproductive system cancer; due to the insidious and unspecific symptomatology of this disease, which, regrettably, has an extremely high mortality. The incidence of this kind of lineage increases with age and, unlike germ and stromal cancers, it is rare before the fifth decade of life. It is important to know that in Mexico as well as in the rest of the world, that the incidence of the different varieties of the histological subtype of ovarian epithelial cancer is as follows: serous (60-80%), mucinous (10-25%), endometrioid (8-20%), clear cells (5%), Brenner tumor (<1%) and not differentiated. Epithelial-serous ovarian cancer is the most frequent in the world; therefore, the one we fear hunts most of our women.
