Bacteriemias en la población de mayores de 80 años / Bloodstream infection in the up to 80 year-old-patients

Introducción. El objetivo de nuestro estudio fue describir las características de las bacteriemias detectadas en pacientes de más de 79 años, e identificar posibles factores relacionados con la mortalidad. Material y métodos. Estudio de cohortes, retrospectivo, en el que se incluye a todos los pacientes de más de 17 años de edad con bacteriemia detectada entre los años 2004-2007. Se recogieron variables demográficas, comorbilidades, foco de la bacteriemia, agente causante, gravedad y mortalidad intrahospitalaria. Los pacientes fueron clasificados en 3 franjas de edad: de 18 a 64 años (G1), de 65 a 79 (G2) y ≥80 años (G3). Resultados. Se analizaron 1.594 episodios de bacteriemia (35% en G1, 35% en G2 y 29% en G3). En el G3, el 47% presentó insuficiencia renal, el 83% neoplasia sólida, el 2% inmunosupresión, el 5% desnutrición y el 38% úlceras por decúbito. Estas proporciones fueron del 27, 30, 5, y 2%, respectivamente en G2, y del 15, 16, 12 y 5%, en G1 (p<0,01). El foco urinario representó el 28, 43 y 44% en G1, G2 y G3, respectivamente (p<0,01) y el biliar, 6, 11 y 16% (p<0,01). E. coli representó el 32% en G1, el 44% en G2 y el 51% en G3. La mortalidad en cada grupo de edad fue del 9, 16 y 21%. En el análisis multivariado, la mortalidad en los ≥80 años se relacionó con la insuficiencia renal, la desnutrición, la presencia de úlceras y el shock. Conclusiones. Las bacteriemias en el anciano son sobretodo de origen urinario. La mortalidad en estos casos depende sobre todo del estado basal del paciente y no tanto de su edad(AU)

Introduction. The aim of our study was to describe the characteristics of bacteremia detected in patients over 79 years and to identify possible factors associated with the mortality. Methods. A retrospective cohort study, which included all patients over 17 years of age with bacteremia detected between 2004-7 was performed. Demographic variables, comorbidities, source of bacteremia, causing microorganism, severity and hospital mortality were recorded. Patients were classified into three age groups: 18 to 64 years (G1), 65 to 79 (G2) and ≥80 years (G3). Results. We analyzed 1594 episodes of bacteremia (35% in G1, 35% in G2 and 29% in G3). In G3, 47% had renal failure, 83% solid neoplasm, 2% immunosuppression 5% malnutrition and 38% decubitus ulcers. These proportions were 27, 30, 5 and 2%, respectively in G2, and 15, 16, 12 and 5% in G1 (P<.01). The urinary focus accounted for 28%, 43% and 44% in G1, G2 and G3, respectively (P<.01) and biliary focus 6, 11 and 16% (P<.01), in each group. E. coli accounted for 32% in G1, 44% in G2 and 51% in G3. Mortality in each age group was 9, 16 and 21%. In multivariate analysis, mortality in the ≥80 years was associated with renal failure, malnutrition, the presence of ulcers and shock. Conclusions. Bacteremia in the elderly are mainly of urinary origin. Mortality in these cases depends primarily on the patient's baseline status rather than their age(AU)

[Bloodstream infection in the up to 80 year-old-patients]. / Bacteriemias en la población de mayores de 80 años.

INTRODUCTION: The aim of our study was to describe the characteristics of bacteremia detected in patients over 79 years and to identify possible factors associated with the mortality. METHODS: A retrospective cohort study, which included all patients over 17 years of age with bacteremia detected between 2004-7 was performed. Demographic variables, comorbidities, source of bacteremia, causing microorganism, severity and hospital mortality were recorded. Patients were classified into three age groups: 18 to 64 years (G1), 65 to 79 (G2) and ≥80 years (G3). RESULTS: We analyzed 1594 episodes of bacteremia (35% in G1, 35% in G2 and 29% in G3). In G3, 47% had renal failure, 83% solid neoplasm, 2% immunosuppression 5% malnutrition and 38% decubitus ulcers. These proportions were 27, 30, 5 and 2%, respectively in G2, and 15, 16, 12 and 5% in G1 (P<.01). The urinary focus accounted for 28%, 43% and 44% in G1, G2 and G3, respectively (P<.01) and biliary focus 6, 11 and 16% (P<.01), in each group. E. coli accounted for 32% in G1, 44% in G2 and 51% in G3. Mortality in each age group was 9, 16 and 21%. In multivariate analysis, mortality in the ≥80 years was associated with renal failure, malnutrition, the presence of ulcers and shock. CONCLUSIONS: Bacteremia in the elderly are mainly of urinary origin. Mortality in these cases depends primarily on the patient's baseline status rather than their age.