Evaluación de la monitorización ambulatoria de la presión arterial en pacientes con obstrucción venosa retiniana / Evaluation of the ambulatory blood pressure monitoring in patients with retinal vein occlusion

Fundamentos La hipertensión arterial (HTA) es el principal factor de riesgo para el desarrollo de la obstrucción venosa retiniana (OVR). Objetivos Analizar el perfil hipertensivo con monitorización ambulatoria de la presión arterial (MAPA) en pacientes con una OVR. Pacientes y métodos Estudio con MAPA en 66 pacientes, 33 con OVR pertenecientes a una cohorte con esta enfermedad y 33 controles sin OVR ajustados por edad y sexo. Resultados Los pacientes con OVR tuvieron, respecto a los controles, cifras nocturnas elevadas de PAS 130mmHg (21) vs.119mmHg (11); p=0,01 y PAD 73mmHg (11) vs. 65mmHg (9); p=0,002. Además, presentaron menor descenso del porcentaje de Dipping ratio 6,0% (10,4) vs. 12,3% (6,3); p=0,005. Conclusiones Los pacientes con OVR tienen un perfil hipertensivo nocturno desfavorable. El reconocimiento de este hecho puede ayudar a optimizar el tratamiento (AU)

Background Arterial hypertension (AHT) is the main risk factor for the development of retinal vein occlusion (RVO). Aims To analyze the hypertensive profile with ambulatory blood pressure monitoring (ABPM) in patients with RVO. Patients and methods Retrospective and observational study of 66 patients with ABPM, 33 with retinal vein occlusion from a cohort of these disease and 33 controls without RVO, adjusted for age and sex. Results Compared to controls, patients with RVO had elevated nocturnal values of SBP 130mmHg (21) vs. 119mmHg (11); P=.01 and DBP 73mmHg (11) vs. 65mmHg (9); P=.002. In addition, they presented a lower decrease in the Dipping ratio percentage 6.0% (10.4) vs. 12.3% (6.3); P=.005. Conclusions Patients with RVO have an unfavorable nocturnal hypertensive profile. Recognition of this fact can help optimize their treatment (AU)

Evaluation of the ambulatory blood pressure monitoring in patients with retinal vein occlusion. / Evaluación de la monitorización ambulatoria de la presión arterial en pacientes con obstrucción venosa retiniana.

BACKGROUND: Arterial hypertension (AHT) is the main risk factor for the development of retinal vein occlusion (RVO). AIMS: To analyze the hypertensive profile with ambulatory blood pressure monitoring (ABPM) in patients with RVO. PATIENTS AND METHODS: Retrospective and observational study of 66 patients with ABPM, 33 with retinal vein occlusion from a cohort of these disease and 33 controls without RVO, adjusted for age and sex. RESULTS: Compared to controls, patients with RVO had elevated nocturnal values of SBP 130mmHg (21) vs. 119mmHg (11); P=.01 and DBP 73mmHg (11) vs. 65mmHg (9); P=.002. In addition, they presented a lower decrease in the Dipping ratio percentage 6.0% (10.4) vs. 12.3% (6.3); P=.005. CONCLUSIONS: Patients with RVO have an unfavorable nocturnal hypertensive profile. Recognition of this fact can help optimize their treatment.

Disseminated Necrotic Suppurative Ulcers as a Manifestation of Cocaine Abuse.

Introduction/Aims/Background: Pyoderma gangrenosum is an immune-mediated illness that can be caused by several affections, such as inflammatory bowel disease, rheumatoid arthritis, and drug use. We present a rare case of pyoderma gangrenosum induced by levamisole-adulterated cocaine. There have been few cases of this disease reported in the world. Levamisole is an anthelmintic drug used to adulterate cocaine to boost its effect. It also has immune-modulating effects causing, among others, vasculitis and dermatological problems. Materials and Methods: Clinical case of a 46-year-old man admitted to the hospital University Marqués de Valdecilla in Santander, Spain, in August 2022. We diagnosed pyoderma gangrenosum based on clinical, analytical, and histological parameters. Results: We report a case of pyoderma gangrenosum induced by consumption of levamisole-adulterated cocaine. Discussion: This patient suffered from a rare and extensive immune-mediated affection with characteristic primary lesions in the form of suppurative ulcers that responded to immunosuppressive treatment. Behind pyoderma gangrenosum there may be underlying conditions such as inflammatory bowel disease, or pyoderma gangrenosum may be secondary to identifiable causes such as cocaine use as in this patient. LEARNING POINTS: Pyoderma gangrenosum induced by levamisole-adulterated cocaine has the following features:History of cocaine use.Exaggerated skin injury occurring after minor trauma (pathergy).Characteristic histopathologic findings.