Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.

BACKGROUND: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms. AIMS: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. MATERIALS AND METHODS: Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications. RESULTS: Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein-Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety. CONCLUSIONS: Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction.

Tumor de células de la granulosa extraovárico / Extraovarian Granulosa cell tumour

Introducción: Los tumores de células de la granulosa,en algunas ocasiones se pueden situar en lugares aberrantesextra gonadales. Estas formas ectópicas son extremadamenteinfrecuentes. Sin embargo, existe un gran debatesobre el origen de estas neoplasias. Objetivo: Describir uncaso de tumor de células de la granulosa extraovárico identificadoen una paciente del Hospital Universitario de Santandery realizar una discusión sobre su génesis, clínica ehistopatología. Caso Clínico: Mujer de 69 años de edad,que consultó por masa abdominal, con historia de histerectomíacon salpingo ooferectomia bilateral, 14 años antes,por múltiples leiomiomas uterinos, a quien se le encontróuna gran masa, dolorosa a la palpación, a nivel de hipocondrioy flanco izquierdo, la cual fue documentada porecografía abdominal y Tomografía Axial Computarizada(TAC), en retroperitoneo a la altura de la cola pancreática.La masa fue resecada, encontrándose numerosas adherenciasque comprometían el riñón izquierdo y el colon. EstudioAnatomo-Patológico: La masa era sólido quística, de950 g y de 12 x 11,5 x 10 centímetros de diámetros mayorescruzados. En el estudio histopatológico e inmunofenotípicose confirmó el diagnóstico de tumor de células de lagranulosa extra ovárico. Estrategia de búsqueda de laliteratura: Se realizó una búsqueda estructurada de la literatura,con base en la metodología Cochrane, en las basesde datos Medline, Imbiomed y Scielo. Conclusión: Lostumores de células de la granulosa extra ováricos son neoplasiasextremadamente infrecuentes, con el presente soloexisten 11 casos reportados, los cuales parecen ser derivadosde tejidos gonadales ectópicos, o de la diferenciación aestos, por parte de células mesenquimales primitivas. Suadecuado estudio por medio de una correcta correlaciónclínica, morfológica e inmunofenotipica, permite su reconocimientoentre un amplio número de diagnósticos diferenciales(AU)

Introduction: Occasionally, granulosa cell tumours arefound in unusual, extragonadal locations, although suchectopic forms are extremely rare and the origin of these neoplasmsis controversial. Objective: A case of extraovariangranulosa cell tumour is described and its origin, clinicalfeatures and histopathology are discussed. Case history: A69 year old woman presented with an abdominal mass. Shehad undergone hysterectomy and bilateral salpingooophorectomyfor uterine leiomyomas 14 years previously. A large,tender mass was present in the left hypochondrium andleft lumbar region, which was seen on abdominal ultrasonographyand CT scan to be situated in the retroperitoneumnear the tail of the pancreas. Surgery revealed that the leftkidney and colon were involved. Pathology: The 950 g,12 × 11.5 × 10 cm mass was composed of both solid andcystic areas. Histological and immunophenotypical findingsindicated a diagnosis of extraovarian granulosa cell tumour.Review of the literature: A review of the literature wasmade from Medline, Imbiomed and Scielo databases, usingthe Cochrane methodology. Conclusion: Extraovarian granulosacell tumours are extremely infrequent neoplasms,with only 10 cases reported to date. They would appear toarise from ectopic gonadal tissue or from the differentiationof primitive mesenchymal cells. Clinical, morphologicaland immunophenotypical features should all be consideredin order to reach a correct differential diagnosis from a widerange of entities(AU)

Tiroiditis de Riedel / Riedel’s thyroiditis

Justificación: La Tiroiditis de Riedel (TR) es una enfermedadinflamatoria crónica de la glándula tiroides, en la cualtejido fibroso reemplaza el parénquima glandular y se extiendea estructuras adyacentes. Objetivo: Describir un caso deTR en una mujer colombiana atendida en el Hospital Universitariode Santander en el año 2006. Caso Clínico: Pacientede sexo femenino, de 63 años de edad, con historia de 6 mesesde evolución, de masa cervical derecha, dolorosa, de 5 cm dediámetro, asociado a astenia y adinamia. Intervención: Tiroidectomíatotal. Resultados: En el lóbulo derecho, se reconociólesión blanquecina, pétrea que compromete difusamentetodo el lóbulo. Los cortes microscópicos mostraron parénquimatiroideo del lóbulo derecho extensamente reemplazadopor tejido fibroso densamente colagenizado, con atrofia marcadade los folículos tiroideos, ocasionales agregados linfoidescon centro germinativo prominente y extensión al tejidoperitiroideo adyacente. El diagnostico fue Tiroiditis de Riedel.Conclusiones: Presentamos un caso de esta inusual yfascinante enfermedad, en la cual se han realizado notablesavances en la patogénesis, al igual que en el diagnostico ymanejo. Son analizadas sus características clínicas, macro,microscópicas e immunohistoquimicas (AU)

Justification: Riedel’s thyroiditis (RT) is a chronicinflammatory disease of the thyroid gland, in which fibroustissue replaces glandular parenchyma and extends to closeststructures. Objective: A case of RT in a Colombian womanattended at the University Hospital of Santander in 2006,will be described. Clinical case: Female Patient, 63 yearsold, with history of 6 months of evolution, cervical massright and painful with 5 cm of diameter, associated to astheniaand adynamia. Intervention: Total thyroidectomy.Results: A diffuse hard whitish lesion affecting the entireright thyroidal lobe was found. Histological sections revealedright thyroidal parenchima widely replaced by denselycollagenized fibrous tissue with marked thyroid folliclesatrophy, scarce lymphoid aggregates with prominent germinalcenters and spread to neighbour perithyroidal tissue. Thediagnosis was Riedel’s thyroiditis. Conclusions:We presenteda case of this unusual and fascinating disease, in whichhave made significant advances in the pathogenesis, diagnoseand treatment. The clinical, gross, microscopic andimmunohistochemical characteristics are analyzed (AU)

[Bellini collecting duct renal carcinoma: case report]. / Carcinoma renal de los túbulos colectores de Belunin: presentación de caso clínico patológico.

OBJECTIVE: The collecting duct carcinoma (Bellini's carcinoma) is an unfrequent lesion; its macro and microscopic characteristics can help diagnosis. 65-year-old Colombian woman presenting left-flank and hypochondrio stub-type episodic pain associated with hematuria, nausea and weight loss. RESULTS: The diagnosis was of collecting duct carcinoma. CONCLUSIONS: The clinical characteristics, macrocospic features, histology and immunohistochemistry are analyzed; we also perform a bibliography review.

Carcinoma renal de los túbulos colectores de Bellini: presentación de un caso clínico patológico / Bellini collecting duct renal carcinoma: case report

Objetivo/Método: El carcinoma de los conductos colectores (Carcinoma de Bellini) es una lesión infrecuente, sus características macro y microscópicas ayudan a su diagnostico, lo cual permite mejores desenlaces en los pacientes. Se presenta el caso de una Mujer Colombiana de 65 años con dolor episódico tipo punzada localizado en hipocondrio y flanco izquierdo, asociado a hematuria, nauseas y perdida de peso. Resultados: El diagnóstico fue carcinoma renal de los túbulos colectores. Conclusiones: Se analizan las características clínicas, macroscópicas, histológicas e inmunohistoquímicas, además se realiza una revisión de la literatura (AU)

Objective: The collecting duct carcinoma (Bellini’s carcinoma) is an unfrequent lesion; its macro and microscopic characteristics can help diagnosis. 65-year-old Colombian woman presenting left-flank and hypochondrio stub-type episodic pain associated with hematuria, nausea and weight loss. Results: The diagnosis was of collecting duct carcinoma. Conclusions: The clinical characteristics, macrocospic features, histology and immunohistochemistry are analyzed; we also perform a bibliography review (AU)