Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 30
Filtrar
1.
J Pediatr Gastroenterol Nutr ; 77(6): e93-e98, 2023 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-37697468

RESUMO

PURPOSE: Recent studies demonstrate the success of Kasai portoenterostomy for biliary atresia (BA) is linearly related to infant age at time of Kasai. We sought to review the feasibility and safety of laparoscopic needle micropuncture cholangiogram with concurrent core liver biopsy (if needed) for expedited exclusion of BA in patients with direct conjugated hyperbilirubinemia. METHODS: Expedited laparoscopic cholangiogram and liver biopsy were instituted at our facility for infants with direct hyperbilirubinemia for whom clinical exam and laboratory workup failed to diagnose. A retrospective chart review was performed in infants <1 year with hyperbilirubinemia from 2016 to 2021. Demographics, preoperative evaluation, procedure details, and complications were reviewed. RESULTS: Two hundred ninety-seven infants with unspecified jaundice were identified, of which, 86 (29%) required liver biopsy. Forty-seven percutaneous liver biopsies were obtained including 8 (17%) in whom BA could not be excluded. Laparoscopic cholangiogram was attempted in 47 infants following basic workup; BA was diagnosed in 22 infants (47%) of which 3 were <18 days old. Biliary patency was demonstrated laparoscopically in 22 of 25 (88%); 3 (12%) required conversion to open cholangiogram. Infants with percutaneous liver biopsy had an average delay of 3 days (range: 2-36) to cholangiogram. Preoperative studies and liver biopsy alone did not reliably exclude the diagnosis of BA. CONCLUSION: Laparoscopic cholangiogram with liver biopsy is a safe procedure resulting in the confirmation or exclusion of BA in infants. Forty-seven percent of infants who underwent laparoscopic cholangiogram were found to have BA; those who were surgical candidates underwent Kasai during the same operation.


Assuntos
Atresia Biliar , Laparoscopia , Humanos , Lactente , Atresia Biliar/diagnóstico , Atresia Biliar/cirurgia , Atresia Biliar/complicações , Biópsia/efeitos adversos , Hiperbilirrubinemia/diagnóstico , Laparoscopia/métodos , Fígado/patologia , Portoenterostomia Hepática/métodos , Estudos Retrospectivos , Resultado do Tratamento , Estudos de Viabilidade
2.
J Pediatr Surg ; 58(8): 1582-1587, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37248140

RESUMO

BACKGROUND/RATIONALE: Anorectal malformations (ARM) are associated with congenital anomalies of the spine, but the impact of a minor spinal cord dysraphism (mSCD) on fecal continence in the setting of ARM remains unclear. MATERIALS/METHODS: A retrospective review was performed utilizing data from the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) registry. The patient cohort was reviewed for ARM type, mSCD screening/incidence/neurosurgical intervention and age-based BMP utilization. RESULTS: 987 patients with ARM were categorized into mild (38%), moderate (32%) or complex (19%). 694 (70%) had normal spinal (NS) status. 271 (27.5%) patients had mSCD. MRI alone (49%) was the most common screening test for mSCD. US screening had a positive predictive value of 86.3% and a negative predictive value of 67.1%. Surgical intervention rates for mSCD ranged between 13% and 77% at a median age of 0.6-5.2 years. 726 (73.6%) patients were prescribed BMP (74.4% NS, 77.5% mSCD). Laxatives were most utilized BMP in all groups <5yo. ≥5yo, enema utilization increased with ARM complexity independent of spine status (with or without neurosurgical intervention). Neurosurgical intervention did not affect BMP utilization at any age or with any ARM when mSCD was identified. CONCLUSIONS: MSCD influence on bowel function in the setting ARM remains unclear. No significant impact of mSCD was noted on ARM patient bowel management program utilization. Variability exists within PCPLC site with screening and intervention for mSCD in patients with ARM. Future studies with standardized care may be needed to elucidate the true impact of mSCD on long term patient outcomes in ARM patients. TYPE OF STUDY: Retrospective Comparative Study. LEVEL OF EVIDENCE: III.


Assuntos
Malformações Anorretais , Neoplasias Colorretais , Cardiopatias Congênitas , Defeitos do Tubo Neural , Disrafismo Espinal , Criança , Humanos , Lactente , Pré-Escolar , Malformações Anorretais/complicações , Malformações Anorretais/diagnóstico , Malformações Anorretais/terapia , Estudos Retrospectivos , Disrafismo Espinal/complicações , Disrafismo Espinal/diagnóstico , Disrafismo Espinal/terapia , Defeitos do Tubo Neural/complicações , Defeitos do Tubo Neural/diagnóstico , Defeitos do Tubo Neural/cirurgia , Medula Espinal/anormalidades , Cardiopatias Congênitas/complicações , Neoplasias Colorretais/complicações
3.
Ann Surg ; 278(1): e1-e2, 2023 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-36912029
4.
Technol Forecast Soc Change ; 189: 122398, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36778643

RESUMO

The emergence of new digital technologies has transformed entrepreneurship and, very likely, enabled many new and established ventures to avoid bankruptcy throughout the COVID-19 pandemic. Digital technologies are key to identifying, evaluating and exploiting opportunities, scaling a venture's competitiveness, improving efficiency and innovating, especially during uncertain times. We explore how digital technologies reinvented entrepreneurial resilience during the COVID-19 pandemic and distill the digital artifacts, platforms and infrastructures used by entrepreneurs to demonstrate entrepreneurial resilience. We analyzed 42 reflective interviews featuring successful entrepreneurs from How I Built This "Resilience Series" podcast that explore how entrepreneurs responded to the COVID-19 crisis. We adopted a systematic approach to identify and describe the behaviors, actions and strategies related to digitalization to reinvent the business in the uncertain and resource-constrained context of COVID-19. The data analysis yielded thirteen first-order codes categorized into five second-order themes: creative digital pivoting, digital infrastructures, social impact through digital technology, burdens to digital adoption, and growth through digitalization. These second-order themes reveal to function as both enablers and barriers to entrepreneurial resilience in this adverse context. Our exploratory analysis suggests how digitalization influences entrepreneurial resilience.

5.
J Pediatr Surg ; 58(2): 325-329, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36428184

RESUMO

BACKGROUND: Many children with blunt liver and/or spleen injury (BLSI) never bleed intraperitoneally. Despite this, decreases in hemoglobin are common. This study examines initial and follow up measured hemoglobin values for children with BLSI with and without evidence of intra-abdominal bleeding. METHODS: Children ≤18 years of age with BLSI between April 2013 and January 2016 were identified from the prospective ATOMAC+ cohort. Initial and follow up hemoglobin levels were analyzed for 4 groups with BLSI: (1) Non bleeding; (2) Bleeding, non transfused (3) Bleeding, transfused, and (4) Bleeding resulting in non operative management (NOM) failure. RESULTS: Of 1007 patients enrolled, 767 were included in one or more of four study cohorts. Of 131 non bleeding patients, the mean decrease in hemoglobin was 0.83 g/dL (+/-1.35) after a median of 6.3 [5.1,7.0] hours, (p = 0.001). Follow-up hemoglobin levels in patients with and without successful NOM were not different. For patients with an initial hemoglobin >9.25 g/dL, the odds ratio (OR) for NOM failure was 14.2 times less, while the OR for transfusion was 11.4 times less (p = 0.001). CONCLUSION: Decreases in hemoglobin are expected after trauma, even if not bleeding. A hemoglobin decrease of 2.15 g/dL [0.8 + 1.35] would still be within one standard deviation of a non bleeding patient. An initial low hemoglobin correlates with failure of NOM as well as transfusion, thereby providing useful information. By contrast, subsequent hemoglobin levels do not appear to guide the need for transfusion, nor correlate with failure of NOM. These results support initial hemoglobin measurement but suggest a lack of utility for routine rechecking of hemoglobin. LEVEL OF EVIDENCE: Level II Prognostic Study.


Assuntos
Traumatismos Abdominais , Ferimentos não Penetrantes , Criança , Humanos , Baço/lesões , Estudos Prospectivos , Hemodiluição , Fígado/lesões , Ferimentos não Penetrantes/terapia , Ferimentos não Penetrantes/cirurgia , Traumatismos Abdominais/complicações , Hemorragia/etiologia , Hemorragia/terapia , Hemoglobinas , Estudos Retrospectivos , Escala de Gravidade do Ferimento
6.
Ann Surg ; 277(3): 367-372, 2023 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-36250327

RESUMO

OBJECTIVE: This survey study aims to determine the prevalence of pregnancy complications and infertility in female physicians in comparison to the general population. Risk factors, workplace environment, and education are also examined. BACKGROUND: Physicians undertake long training and have stressful work environments during optimal childbearing years. While growing literature indicates increased rates of pregnancy complications and infertility in female surgeons, the prevalence in female physicians of all specialties is unknown. METHODS: An anonymous, voluntary survey was distributed to female physicians via private physician social media groups. It queried pregnancy demographics and complications, infertility diagnosis and treatment, workplace environment, and prior education on these topics. Results were compared with general population data, between medical and surgical subspecialties, and between physicians who were and were not educated on the risks of delaying pregnancy. RESULTS: A total of 4533 female physicians completed the survey. Compared with the general population, female physicians were older at first pregnancy, more often underwent infertility evaluation and treatment, and had higher rates of miscarriage and preterm birth. During training, only 8% of those surveyed received education on the risks of delaying pregnancy. Those who were educated were significantly less likely to experience miscarriage or seek infertility evaluation or treatment. Compared with physicians in nonsurgical specialties, surgeons had fewer children, were older at first pregnancy, had more preterm births and fetal growth problems, and were more likely to be discouraged from starting a family during training and practice. CONCLUSIONS: Female physicians, particularly surgeons, have a significantly greater incidence of miscarriage, infertility, and pregnancy complications compared with the general population. The culture of medicine and surgery must continue to evolve to better support women with family planning during their training and careers.


Assuntos
Aborto Espontâneo , Infertilidade Feminina , Infertilidade , Complicações na Gravidez , Nascimento Prematuro , Cirurgiões , Gravidez , Criança , Feminino , Recém-Nascido , Humanos , Infertilidade/complicações , Complicações na Gravidez/epidemiologia , Infertilidade Feminina/epidemiologia , Infertilidade Feminina/etiologia , Infertilidade Feminina/terapia
7.
J Pediatr Surg ; 58(3): 467-470, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35934522

RESUMO

INTRODUCTION: The objective of this study is to assess the postoperative outcomes of single-stage repair of anorectal malformations with vestibular (VF) or perineal fistula (PF) and early initiation of postoperative feeding. METHODS: A retrospective review of patients undergoing single-stage repair of isolated low anorectal malformations (VF and PF) from 2017 to 2020 was conducted. All patients underwent an anterior anoplasty with complete mobilization of the rectal fistula, or posterior sagittal anorectoplasty (PSARP), without protective colostomy. The variables examined include age, timing of postoperative feeding initiation, length of stay (LOS), and complications. RESULTS: Nineteen patients with VF or PF underwent a single-stage repair. 12/19 (63%) patients were female. All 7 males and 9/12 females had a PF. The range of age at surgery was 2 days to 3 years with median age of 92 days [IQR 1,3: 9,193]. The median postoperative day for initiation of feeds was day 0 [IQR 1,3: 0,1] and median LOS was 1 day [IQR 1,3: 1,4.5]. 18/19 (95%) patients were evaluated in follow-up and there were no wound infections, wound dehiscences, or recurrent fistulas. Within 90 days postoperatively, no patients were seen in the emergency department for postoperative issues. Within 6 months, 2/19 (11%) patients required an unplanned return to the operating room for anal dilation. CONCLUSION: In single-stage repair of isolated low anorectal malformations, VF and PF, early initiation of postoperative feeding is safe, results in a short length of stay, and does not lead to increased wound complications. Early enteral feeding eliminates the need for parenteral nutrition and central venous access, and their associated complications. LEVEL OF EVIDENCE: Level IV.


Assuntos
Malformações Anorretais , Fístula Retal , Masculino , Humanos , Feminino , Lactente , Malformações Anorretais/cirurgia , Reto/cirurgia , Fístula Retal/cirurgia , Canal Anal/cirurgia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Estudos Retrospectivos
8.
J Pediatr Surg ; 57(6): 1033-1039, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35292167

RESUMO

PURPOSE: Botulinum toxin (BT) is used to treat pediatric patients with Hirschsprung disease (HD) with obstructive symptoms. We aimed to characterize use of BT in HD patients across pediatric colorectal surgery referral centers. METHODS: A multicenter retrospective study of BT use in children (0-18y) with HD was performed using the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) between 2017 and 2021. Sites with <10 HD patients recorded were excluded. Patterns were evaluated using Fisher's exact, Wilcoxon rank-sum, Kruskal-Wallis, and Cochran-Armitage trend test. RESULTS: 494 patients at 8 centers were included. 118 (23.9%) received at least one BT injection. Among patients who required redo pullthrough procedures, 53.1% received BT compared to 22.7% of patients who only underwent one pullthrough (p<0.001). Age at pullthrough was also significantly associated (p = 0.021). A lower proportion of Hispanic patients received BT (9.6% vs. 26.3%;p = 0.006). Percentage of HD patients receiving BT varied significantly across sites (p<0.001). CONCLUSIONS: Use of BT in patients with HD varies widely with greater use in patients who underwent redo surgery and in those who underwent pullthrough at an older age. Hispanic patients received less BT. These findings highlight the need to develop consensus guidelines and for further study on timing of injections and potential disparities in care. LEVEL OF EVIDENCE: III.


Assuntos
Toxinas Botulínicas Tipo A , Toxinas Botulínicas , Cirurgia Colorretal , Doença de Hirschsprung , Adolescente , Toxinas Botulínicas Tipo A/uso terapêutico , Criança , Pré-Escolar , Doença de Hirschsprung/cirurgia , Humanos , Lactente , Recém-Nascido , Encaminhamento e Consulta , Estudos Retrospectivos , Resultado do Tratamento
9.
J Pediatr Surg ; 57(2): 297-301, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34758909

RESUMO

BACKGROUND: Economic, social, and psychologic stressors are associated with an increased risk for abusive injuries in children. Prolonged physical proximity between adults and children under conditions of severe external stress, such as witnessed during the COVID-19 pandemic with "shelter-in-place orders", may be associated with additional increased risk for child physical abuse. We hypothesized that child physical abuse rates and associated severity of injury would increase during the early months of the pandemic as compared to the prior benchmark period. METHODS: We conducted a nine-center retrospective review of suspected child physical abuse admissions across the Western Pediatric Surgery Research Consortium. Cases were identified for the period of April 1-June 30, 2020 (COVID-19) and compared to the identical period in 2019. We collected patient demographics, injury characteristics, and outcome data. RESULTS: There were no significant differences in child physical abuse cases between the time periods in the consortium as a whole or at individual hospitals. There were no differences between the study periods with regard to patient characteristics, injury types or severity, resource utilization, disposition, or mortality. CONCLUSIONS: Apparent rates of new injuries related to child physical abuse did not increase early in the COVID-19 pandemic. While this may suggest that pediatric physical abuse was not impacted by pandemic restrictions and stresses, it is possible that under-reporting, under-detection, or delays in presentation of abusive injuries increased during the pandemic. Long-term follow-up of subsequent rates and severity of child abuse is needed to assess for unrecognized injuries that may have occurred.


Assuntos
COVID-19 , Maus-Tratos Infantis , Adulto , Criança , Humanos , Pandemias , Abuso Físico , Estudos Retrospectivos , SARS-CoV-2 , Centros de Traumatologia
10.
Plast Reconstr Surg Glob Open ; 9(10): e3837, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34616640

RESUMO

Large abdominal wall and groin defects present complex reconstructive challenges. These defects typically require free flap reconstruction to bring in healthy vascularized tissue and recreate the complex full-thickness defect. A 6-year-old previously healthy girl presented to our trauma center after sustaining a close-range shotgun injury resulting in a full-thickness defect to the inferior hemi-abdomen and groin. A composite anterolateral thigh flap with fascia lata free flap was performed to reconstruct the myofascial, skin, and subcutaneous tissue of the abdomen and groin. We present the first composite anterolateral thigh flap with fascia lata for full-thickness abdominal wall and groin reconstruction in a pediatric patient.

11.
Ann Surg ; 274(3): 406-410, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34132703

RESUMO

BACKGROUND: Perforated appendicitis is the most common cause of intraabdominal abscess (IAA) in children. The optimal postoperative antibiotic regimen to reduce IAA has evolved in the last decade from triple-drug to 2-drug therapy (CM). Recent retrospective studies show decreased infectious complications with monotherapy PT. To date prospective comparative data are lacking. Therefore, a prospective randomized trial comparing PT versus CM was conducted. METHODS: A multi-institutional prospective randomized trial was performed in children with perforated appendicitis comparing postoperative antibiotic regimens PT or CM. The primary outcome was 30-day postoperative IAA formation. Perforation was strictly defined as a hole in the appendix or fecalith in the abdomen, documented with intraoperative photographs. RESULTS: One hundred sixty-two patients were enrolled during the study period. No differences in age, weight, or duration of presenting symptoms were identified. In addition, length of stay, duration of intravenous antibiotic treatment, discharge oral antibiotic treatment, and antibiotic-related complications did not differ between groups. Compared to the CM group, the PT group had significantly lower IAA rate [6.1% vs 23.8%, odd ratio (OR) 4.80, P = 0.002], lower postoperative computed tomography imaging rate (13.9% vs 29.3%, OR 2.57, P = 0.030), and fewer emergency room visits (8.8% vs 26.4%, OR 3.73, P = 0.022). Multivariate logistic regression analysis found the use of CM versus PT (OR 9.21, P = 0.021) to be the most significant predictor for developing IAA. CONCLUSIONS: In children with perforated appendicitis, postoperative monotherapy with PT is superior to standard 2-drug therapy with CM and does not increase antibiotic-related complications or antibiotic exposure duration.


Assuntos
Abscesso Abdominal/tratamento farmacológico , Antibacterianos/administração & dosagem , Apendicite/cirurgia , Complicações Pós-Operatórias/tratamento farmacológico , Gestão de Antimicrobianos , Apendicectomia , Criança , Feminino , Humanos , Infusões Intravenosas , Masculino , Fotografação , Estudos Prospectivos
12.
J Pediatr Surg ; 56(5): 892-899, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33139033

RESUMO

INTRODUCTION: Mentorship in surgical training is critical but differs greatly from the early apprenticeship model and often spans generations. This study evaluates the current state of and desire for structured mentorship in pediatric surgical training from the perspective of program directors (PDs) and trainees. METHODS: A survey addressing demographics, presence of or desire for structured mentorship, and proposed mentoring topics was emailed to pediatric surgery PDs (n = 58) and trainees completing fellowship in 2018-2020 (n = 72). RESULTS: The response rate was 38.5%. 50% of trainees were female versus 15% of PDs (p = 0.02). 19% of trainees reported having a structured mentorship program versus 26% of PDs (p = 0.72). The majority, 83%, of trainees felt a structured mentorship program is warranted versus 40% of PDs (p = 0.002). There were differing opinions between trainees and PDs regarding important components of a mentoring program. Trainees felt the following were more important: transition to practice, job negotiation, CV review, financial planning and performance review. PDs felt the following were more important: quality improvement projects and work/life balance. Both agreed academic development and job search were important. CONCLUSIONS: The majority of pediatric surgery trainees desire structured mentorship programs; however, few institutions have them. Training programs and program directors warrant a response to this gap. LEVEL OF EVIDENCE: IV.


Assuntos
Tutoria , Especialidades Cirúrgicas , Criança , Bolsas de Estudo , Feminino , Humanos , Mentores , Inquéritos e Questionários
13.
J Pediatr Surg ; 55(12): 2752-2757, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32616413

RESUMO

BACKGROUND/RATIONALE: To describe current bowel management program (BMP) strategies in anorectal malformation (ARM) patients based on patient-level predictors using data from a multi-institutional consortium. MATERIALS/METHODS: Patient bowel function and BMP were reviewed from Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) data. The PCPLC is comprised of multidisciplinary specialists researching colorectal and pelvic disorders. Seven US institutions submitted de-identified clinical data on ARM patients into a centralized patient registry. RESULTS: The primary ARM of 624 patients was categorized into Mild (45.2%), Moderate (40.4%) or Complex (14.2%) anomaly classifications. Patient-specific BMP were examined based on age and on the presence of spinal cord/sacral anomalies. 418 (67%) enrolled patients were prescribed BMP (<5 yo 56.4%; ≥5-<12 yo 86.7%; ≥12 81.5%). Constipation was the primary chief complaint (80.2%). Forty percent of patients on a BMP were toilet trained and approximately one-half (48.5%) reported daytime stool accidents. Secondary surgical interventions for antegrade continence enemas (ACE) were examined; 14.5% of patients employed ACE strategies and utilization increased with age and varied based on anatomic anomalies. CONCLUSIONS: This is the first report on BMP strategies for patients with ARM from the Pediatric Colorectal and Pelvic Learning Consortium. Individual patient characteristics are explored for their impact on bowel management strategy utilization. LEVEL OF EVIDENCE: IV.


Assuntos
Malformações Anorretais , Incontinência Fecal , Criança , Constipação Intestinal/etiologia , Constipação Intestinal/terapia , Enema , Incontinência Fecal/etiologia , Incontinência Fecal/terapia , Humanos , Intestinos , Estudos Retrospectivos
14.
Semin Pediatr Surg ; 29(3): 150929, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32571514

RESUMO

Rare medical conditions are difficult to study due to the lack of patient volume and limited research resources, and as a result of these challenges, progress in the care of patients with these conditions is slow. Individuals born with differences of sex development (DSD) fall into this category of rare conditions and have additional social barriers due to the intimate nature of the conditions. There is also a lack of general knowledge in the medical community about this group of diverse diagnoses. Despite these limitations, progress has been made in the study of effective ways to care for patients who are born with chromosomal or anatomical differences of their internal reproductive organs or external genitalia. Advocacy groups have placed a spotlight on these topics and asked for a thoughtful approach to educate parents of newborns, medical providers, and the adolescents and young adults themselves as they mature.1 There is growing interest in the approaches to surgical reconstruction of the genitalia and the management of internal gonads, specifically the timing of procedures and the indications for those procedures.2 Advocates suggest deferring surgical procedures until the affected individual can participate in the decision-making process. This approach requires a roadmap for addressing the long-term implications of delayed surgical management. Presented here is a review of the specific issues regarding the complex management of the various categories of DSD.


Assuntos
Transtornos do Desenvolvimento Sexual/cirurgia , Participação do Paciente , Procedimentos de Cirurgia Plástica/métodos , Procedimentos Cirúrgicos Urogenitais/métodos , Adolescente , Fatores Etários , Criança , Pré-Escolar , Transtornos do Desenvolvimento Sexual/diagnóstico , Transtornos do Desenvolvimento Sexual/psicologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Participação do Paciente/métodos , Participação do Paciente/psicologia , Assistência Centrada no Paciente , Relações Profissional-Família , Relações Profissional-Paciente , Procedimentos de Cirurgia Plástica/ética , Procedimentos de Cirurgia Plástica/psicologia , Procedimentos Cirúrgicos Urogenitais/ética , Procedimentos Cirúrgicos Urogenitais/psicologia , Adulto Jovem
15.
Semin Pediatr Surg ; 28(5): 150841, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31668295

RESUMO

Individuals born on the spectrum of genetic abnormalities known as mixed gonadal dysgenesis (MGD) have a wide range of anatomical findings and management can be challenging in the newborn and adolescent. Historically, many individuals with MGD have undergone gonadectomy to avert the risk of gonadal malignancy. However, gonadectomy deprives patients of the benefits of their endogenous hormones, potential fertility, and in the case with MGD, has historically been done prior to addressing gender identity. Some patient advocates have proposed a delayed approach to surgical reconstructions and/or gonadectomy in other differences/disorders of sex development (DSD), particularly in patients with congenital adrenal hyperplasia and androgen insensitivity syndrome. In many areas of the world, there continues to be a shift toward delayed reconstructions and hesitancy regarding irreversible gonadectomy. To date, no clinical management protocol addressing these issues from a patient-centered approach has been described. We review what is known about malignancy risk and propose a management protocol for those with MGD that involves shared decision making regarding the gonads and addresses the long-term challenges with regard to gender and anatomy.


Assuntos
Disgenesia Gonadal Mista/diagnóstico , Disgenesia Gonadal Mista/terapia , Mosaicismo , Adolescente , Biópsia , Tomada de Decisão Compartilhada , Ética Médica , Fertilidade , Identidade de Gênero , Predisposição Genética para Doença , Terapia de Reposição Hormonal , Humanos , Imuno-Histoquímica , Recém-Nascido , Cariotipagem , Laparoscopia , Imageamento por Ressonância Magnética , Neoplasias Embrionárias de Células Germinativas/genética , Exame Físico , Ultrassonografia
16.
J Laparoendosc Adv Surg Tech A ; 28(11): 1387-1392, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30096007

RESUMO

BACKGROUND: Cardiac sympathetic denervation (CSD) is a surgical option for patients with life-threatening ventricular arrhythmias. Previously described cohorts included populations in which CSD was performed for primary and secondary prevention. We report the efficacy of CSD as adjunct therapy in children with medically refractory life-threatening arrhythmias. MATERIALS AND METHODS: Retrospective review of patients undergoing thoracoscopic CSD at one institution between January 2008 and July 2017. Patient demographics, indications, procedural details, complications, length of stay, and effectiveness were evaluated. RESULTS: Ten thoracoscopic CSD procedures were performed in 8 patients. Mean age was 8.2 years (8 days-19 years); mean weight was 32.6 kg (2.7-57 kg); and 50% were female. Four had long QT syndrome, 3 catecholaminergic polymorphic ventricular tachycardia, and 1 short QT syndrome. All patients had at least two (2 to >40) episodes of resuscitated ventricular arrhythmia and were maximized on medical therapy. Six patients had implantable cardioverter-defibrillators (ICD) with a mean of 11.9 appropriate discharges (1-40) before CSD. All patients underwent left CSD; 2 subsequently required right CSD. Four of the 6 ICD patients experienced dramatic improvement (total 48 ICD discharges pre-CSD; 3 post-CSD). Two patients noncompliant with medical therapy had no significant improvement (24 ICD discharges pre-CSD; 23 post-CSD) and also underwent right CSD, again with no improvement (23 discharges pre-right CSD; 28 post-right CSD). CONCLUSIONS: Thoracoscopic CSD can be safely performed in the neonate and pediatric populations. When utilized with medication therapy, CSD is an effective adjunct in reducing ICD discharges and arrhythmias.


Assuntos
Coração/inervação , Prevenção Secundária/métodos , Simpatectomia/métodos , Taquicardia Ventricular/prevenção & controle , Toracoscopia/métodos , Adolescente , Adulto , Arritmias Cardíacas , Criança , Pré-Escolar , Terapia Combinada , Desfibriladores Implantáveis , Feminino , Coração/fisiopatologia , Sistema de Condução Cardíaco/anormalidades , Cardiopatias Congênitas , Humanos , Lactente , Recém-Nascido , Tempo de Internação , Síndrome do QT Longo , Masculino , Estudos Retrospectivos , Adulto Jovem
17.
J Surg Res ; 229: 76-81, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29937019

RESUMO

BACKGROUND: The ability of ultrasound to identify specific features relevant to nonoperative management of pediatric appendicitis, such as the presence of complicated appendicitis (CA) or an appendicolith, is unknown. Our objective was to determine the reliability of ultrasound in identifying these features. METHODS: We performed a retrospective study of children who underwent appendectomy after an ultrasound at four children's hospitals. Imaging, operative, and pathology reports were reviewed. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ultrasound for identifying CA based on pathology and intraoperative findings and an appendicolith based on pathology were calculated. CA was defined as a perforation of the appendix. Equivocal ultrasounds were considered as not indicating CA. RESULTS: Of 1027 patients, 77.5% had simple appendicitis, 16.2% had CA, 5.4% had no evidence of appendicitis, and 15.6% had an appendicolith. Sensitivity and specificity of ultrasound for detecting CA based on pathology were 42.2% and 90.4%; the PPV and NPV were 45.8% and 89.0%, respectively. Sensitivity and specificity of ultrasound for detecting CA based on intraoperative findings were 37.3% and 92.7%; the PPV and NPV were 63.4% and 81.4%, respectively. Sensitivity and specificity of ultrasound for detecting an appendicolith based on pathology were 58.1% and 78.3%; the PPV and NPV were 33.1% and 91.0%, respectively. Results were similar when equivocal ultrasound and negative appendectomies were excluded. CONCLUSIONS: The high specificity and NPV suggest that ultrasound is a reliable test to exclude CA and an appendicolith in patients being considered for nonoperative management of simple appendicitis.


Assuntos
Apendicectomia/estatística & dados numéricos , Apendicite/diagnóstico por imagem , Apêndice/diagnóstico por imagem , Perfuração Intestinal/diagnóstico , Seleção de Pacientes , Adolescente , Antibacterianos/uso terapêutico , Apendicite/complicações , Apendicite/patologia , Apendicite/terapia , Apêndice/patologia , Apêndice/cirurgia , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Perfuração Intestinal/epidemiologia , Perfuração Intestinal/etiologia , Perfuração Intestinal/prevenção & controle , Masculino , Valor Preditivo dos Testes , Período Pré-Operatório , Prognóstico , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Ultrassonografia
18.
Ann Surg Oncol ; 25(1): 18-27, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28058560

RESUMO

BACKGROUND: Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS: A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. The analysis included 106 papers focused on intraoperative management of breast cancer margins and contained actionable data. RESULTS: Ultrasound-guided lumpectomy for palpable tumors, as an alternative to palpation guidance, can lower positive margin rates, but the effect when used as an alternative to wire localization (WL) for nonpalpable tumors is less certain. Localization techniques such as radioactive seed localization and radioguided occult lesion localization were found potentially to lower positive margin rates as alternatives to WL depending on baseline positive margin rates. Intraoperative pathologic methods including gross histology, frozen section analysis, and imprint cytology all have the potential to lower the rates of positive margins. Cavity-shave margins and the Marginprobe device both lower rates of positive margins, with some potential for negative cosmetic effects. Specimen radiography and multiple miscellaneous techniques did not affect positive margin rates or provided too little evidence for formation of a conclusion. CONCLUSIONS: A systematic review of the literature showed evidence that several intraoperative techniques and actions can lower the rates of positive margins. These results are presented together with graded recommendations.


Assuntos
Neoplasias da Mama/cirurgia , Margens de Excisão , Mastectomia Segmentar/métodos , Feminino , Secções Congeladas , Humanos , Período Intraoperatório , Palpação , Ondas de Rádio , Reoperação , Análise Espectral , Ultrassonografia de Intervenção
19.
Semin Pediatr Surg ; 26(2): 61-66, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28550872

RESUMO

Hiatal and paraesophageal hernia (HH/PEH) can be congenital, resulting from embryologic abnormalities/genetic predisposition, or acquired, most commonly after gastroesophageal surgery such as fundoplication. Minimizing circumferential esophageal dissection at the time of Nissen fundoplication has been shown to decrease the risk of acquired HH/PEH from 36.5% to 12.2%. Gastrointestinal, respiratory, and constitutional symptoms, including anemia and failure to thrive, are common with high rates of associated gastroesophageal reflux. Chest x-ray is often abnormal and upper GI confirms the diagnosis. Treatment is surgical with the goal of reducing the hernia contents, excising the hernia sac, closing the crura, and performing an antireflux procedure. The laparoscopic approach is safe and effective.


Assuntos
Hérnia Hiatal/cirurgia , Herniorrafia/métodos , Laparoscopia/métodos , Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido
20.
J Pediatr Surg ; 52(2): 327-333, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27670961

RESUMO

PURPOSE: To identify injuries and outcomes from Recreational/Off-Highway Vehicles (RV/OHV) accidents at a pediatric trauma center. METHODS: A retrospective review of a prospective pediatric trauma registry was performed to identify patients sustaining injuries from an RV/OHV between January 2007 and July 2015. Vehicles included: all-terrain vehicles (ATV), dirt bikes, utility-terrain vehicles (UTV), golf carts, go-karts, and dune buggies. RESULTS: Five hundred twenty-eight patients were injured while on an RV/OHV: 269 ATV, 135 dirt bike, 42 UTV, 38 golf cart, 34 go-kart, and 10 dune buggy. The majority (n=381, 72%) had at least one injury with an Abbreviated Injury Scale ≥2; 39% (n=204) had orthopedic injuries and 22% (n=116) had central neurologic injuries. Over three-fourths (n=412, 78%) were admitted. For the 48% (n=253) of patients requiring surgery, 654 surgical procedures were performed. Median hospital charge was $27,565 (IQR: $15,553-$44,935). Excluding golf carts, helmet use was 49% (n=231); 16% (n=76) wore protective clothing. Only 22% (n=26) wore a restraining belt. CONCLUSION: Severe injuries occur in children who ride RV/OHV often warranting admission and surgical intervention. Improved understanding of RV/OHV injuries may guide caregivers in decision-making about pediatric RV/OHV use and encourage use of protective gear. LEVEL OF EVIDENCE: Level II, Prognosis Study.


Assuntos
Acidentes , Veículos Off-Road , Ferimentos e Lesões/etiologia , Adolescente , Arizona/epidemiologia , Criança , Pré-Escolar , Feminino , Dispositivos de Proteção da Cabeça/estatística & dados numéricos , Hospitalização/estatística & dados numéricos , Hospitais Pediátricos , Humanos , Lactente , Masculino , Roupa de Proteção/estatística & dados numéricos , Sistema de Registros , Estudos Retrospectivos , Centros de Traumatologia , Resultado do Tratamento , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/terapia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...