Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Adenocarcinoma/complicações , Adenocarcinoma/patologia , Adenocarcinoma/epidemiologia , Neoplasias do Colo/complicações , Neoplasias do Colo/patologia , Neoplasias do Colo/epidemiologia , Período Pós-Operatório , Neoplasias Retais/complicações , Neoplasias Retais/patologia , Neoplasias Retais/epidemiologia , Fatores Etários , Distribuição por Sexo , Avaliação de Estado de Karnofsky , México/epidemiologiaAssuntos
Adenocarcinoma , Neoplasias do Colo , Avaliação de Estado de Karnofsky , Neoplasias Retais , Adenocarcinoma/complicações , Adenocarcinoma/epidemiologia , Adenocarcinoma/patologia , Adulto , Fatores Etários , Idoso , Neoplasias do Colo/complicações , Neoplasias do Colo/epidemiologia , Neoplasias do Colo/patologia , Feminino , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Período Pós-Operatório , Neoplasias Retais/complicações , Neoplasias Retais/epidemiologia , Neoplasias Retais/patologia , Distribuição por SexoRESUMO
The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman's rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p < 0.05) with visits to clinics, municipalities and comorbidities (primarily diabetes mellitus). S correlated with drug consumption and M with comorbidities. SMR is needed to identify a social network in metropolitan areas for PTB transmission and S and M are able to detect risk factors as secondary components of a transmission chain of TB.
Assuntos
Técnicas de Genotipagem/métodos , Mycobacterium tuberculosis/genética , Tuberculose Pulmonar/microbiologia , Tuberculose Pulmonar/transmissão , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Cidades , Comorbidade , DNA Bacteriano/isolamento & purificação , Feminino , Genótipo , Humanos , Sequências Repetitivas Dispersas/genética , Masculino , México/epidemiologia , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Epidemiologia Molecular/métodos , Mycobacterium tuberculosis/classificação , Mycobacterium tuberculosis/isolamento & purificação , Polimorfismo de Fragmento de Restrição/genética , Fatores de Risco , Fatores Sociológicos , Estatísticas não Paramétricas , Sequências de Repetição em Tandem/genética , Tuberculose Pulmonar/epidemiologia , Tuberculose Pulmonar/genética , População Urbana , Adulto JovemRESUMO
The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman’s rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p < 0.05) with visits to clinics, municipalities and comorbidities (primarily diabetes mellitus). S correlated with drug consumption and M with comorbidities. SMR is needed to identify a social network in metropolitan areas for PTB transmission and S and M are able to detect risk factors as secondary components of a transmission chain of TB.