Risk factors of mortality among COVID-19 patients receiving non-invasive ventilation at Addis Ababa governmental COVID-19 treatment centers

Introduction: during the global COVID-19 pandemic, non-invasive ventilation has become a widely utilized method for treating patients experiencing acute respiratory failure. Noninvasive pressure ventilation is frequently employed as a standard approach for managing acute respiratory failure resulting from COVID-19 pneumonia, as opposed to invasive ventilation methods. However, there is a lack of research on its effectiveness. Therefore, this study aimed to determine the risk of mortality among COVID-19 patients receiving non-invasive ventilation. Methods: a multi-centric retrospective cross sectional study was conducted on the records of 402 patients at the Eka Kotebe COVID-19 Center, St. Peter COVID-19 Care Center, and Millennium COVID-19 Treatment Center. The systematic random selection technique was employed in order to select the study unit, and data was extracted from patient charts using a pretested method and validated before being entered into Epi-data Manager 4.6 versions. Descriptive, bivariate, and multivariable analyses were performed using binary logistic regression in SPSS 25. In the multivariate logistic regression, a predictor variable was considered to have a significant connection if its p-value was less than 0.05 at a 95% confidence level. Results: four hundred and two patient records were reviewed during the study period and showed the mean patient´s age was 62.6 years, with male predominance. It revealed that 11.7% [CI: 8.7-15.2] of COVID-19 patients who received non-invasive positive pressure ventilation died, as being critical for COVID-19 patients was a main cause of noninvasive initiation. Patients over the age of 60 were more likely to die among those who received noninvasive ventilation for COVID-19 [AOR = 5.4 95% CI 1.32, 23.1]. Conversely, patients without diabetes were less likely to die [AOR = 0.23 95% CI 0.11, 0.48]. Moreover, patients with a tidal volume greater than 500 ml were more likely to pass away [AOR =2.2 95% CI 1.11,4.43], as were those who were on non-invasive ventilation (NIV) for more than 8 days [AOR = 0.24 95% CI.08, 0.81]. Conclusion: the significance of patients who were given non-invasive ventilators ended up dying. Age, diabetes, and high tidal volumes are linked to a higher risk of death. Non-invasive ventilation for over eight days showed a protective effect. Removing factors that caused NIV and ventilated COVID-19 patients' deaths may reduce mortality.

Improving fertilizer response of crop yield through liming and targeting to landscape positions in tropical agricultural soils.

Nutrient management research was conducted across locations to investigate the influence of landscape position (hill, mid-, and foot slope) in teff (Eragrostis tef) and wheat (Triticum aestivum) yield response to fertilizer application and liming in the 2018 and 2019 cropping seasons. The treatments included 1) NPS fertilizer as a control treatment (42 N + 10P + 4.2S kg ha-1 for teff and 65 N + 20P + 8.5S kg ha-1 for wheat); 2) NPS and potassium (73 N + 17P + 7.2S + 24 K kg ha-1 for teff and 103 N + 30P + 12.7S + 24 K kg ha-1 for wheat) and 3) NPSK and zinc (73 N + 17P + 7.2S + 24K + 5.3Zn kg ha-1 for teff and 103 N + 30P + 12.7S + 24K + 5,3Zn kg ha-1 for wheat) in acid soils with and without liming. Results showed that the highest teff and wheat grain yields of 1512 and 4252 kg ha-1 were obtained at the foot slope position, with the respective yield increments of 71% and 57% over the hillslope position. Yield response to fertilizer application significantly decreased with increasing slope owing to the decrease in soil organic carbon and soil water content and the increase in soil acidity. The application of lime with NPSK and NPSKZn fertilizer increased teff and wheat yields by 43-54% and 32-35%, respectively compared to the application of NPS fertilizer without liming where yield increments were associated with the application of N and P nutrients. Orthogonal contrasts revealed that landscape position, fertilizer application, and their interaction effects were significant on teff and wheat yields. Soil properties including soil pH, organic carbon, total N, and soil water content were increased down the slope, which might be attributed to sedimentation down the slope. However, available P is yet very low both in acidic and non-acidic soils. We conclude that crop response to applied nutrients could be enhanced by targeting nutrient management practices to agricultural landscape features and addressing other yield-limiting factors such as soil acidity and nutrient availability by conducting further research.

The impact of the use of new technologies on farmers' wheat yield in Ethiopia: evidence from a randomized control trial.

In 2013, Ethiopia's Agricultural Transformation Agency introduced the Wheat Initiative to increase smallholder productivity. In this article, we measure the impacts of the Wheat Initiative package of technologies, and its marketing assistance component alone, on yields among a promotional group of farmers. The package includes improved techniques, improved inputs, and a guaranteed market for the crop. Relying on crop-cut measures and farmers' own assessments, we find that full package led to an average 14% higher yields. Implementation of the Wheat Initiative was successful in making certified seed and fertilizer accessible to farmers and increasing their uptake, though only 61% of the intervention group adopted row planting and few farmers received marketing assistance. The measured yield difference may underestimate the true yield difference associated with the technology because of incomplete adoption of the recommended practices by intervention farmers and adoption of some practices by control farmers.