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1.
Klin Lab Diagn ; 64(2): 104-110, 2019.
Artigo em Russo | MEDLINE | ID: mdl-30917252

RESUMO

As a result of the conducted researches it is shown that 44.1% of urinary tract infections (UTIS) caused by E. coli are accounted for by producers of beta-lactamase of the extended spectrum of action (ESBL). Associated resistance to fluoroquinolones and co-trimoxazole was found in 93.3% of BLRS-producing E. coli strains. All studied strains regardless of ESBL production were sensitive to imipenem, the majority showed sensitivity to ertapenem, gentamicin and resistance to doxycycline. Not producing ESBL strains of E. coli were sensitive to fosfomycin. Comparison of data obtained during testing of isolated cultures on ESBL, study of their sensitivity and resistance to beta-lactams (amoxicillin/clavulanate, ceftazidime, ceftriaxone, cefotaxime, imipenem) indicates the need to test isolates for AmpC products. To this end, during the screening test for ESBL and the method of «double disks¼, along with cephalosporins of III generation, it is necessary to use a phenotypic test for sensitivity to cefepime. The use of test results of E. coli isolates isolated from patients with UTIS for the production of ESBL, ampC enzymes, carbapenemase and sensitivity to AMP will improve the effectiveness of antimicrobial therapy and will help to curb the formation and spread of antimicrobial-resistan strains.


Assuntos
Antibacterianos/uso terapêutico , Escherichia coli/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Infecções Urinárias/tratamento farmacológico , Cefalosporinas , Farmacorresistência Bacteriana , Humanos , Infecções Urinárias/microbiologia
2.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-30695529

RESUMO

AIM: Study the frequency of occurrence of antibiotics resistant strains of various species of Corynebacterium non diptheriae. MATERIALS AND METHODS: C.pseudodiphtheriticum, C.pseudo- tuberculosis, C.xerosis, C.amycolatum, C.striatum, C. ulcerans strains isolated from patients with pathologies of respiratory and urogenital tract, as well as individuals taking prophylaxis ex- amination were used. Sensitivity to antibacterial preparations was determined by the serial dilution method. RESULTS: The highest number of Coryniebacterium non diptheriae strains dis- played resistance to benzylpenicillin (54.8%) and lincomycin (50.7%), and lowest - to cefotaxime, cefazolin (6.8%) and vancomycin (13.7%). The highest number of antibiotics resistant strains were detected among members of C.pseudotuberculosis (100%), C.xerosis (96.0%) and C. pseudodiphtheriticum (81.0%) species. Polyresistant strains were detected most frequently among C.xerosis, C.amycolatum and C.striatum species. Strains of Corynebacterium non diptheriae most frequently displayed resistance to 1 or 2 antibacterial preparations (24.7%), less frequently - to 3 (20.5%); 4 (13.7%), 5 (4.1%) and 6 (1.4%) preparations. CONCLUSION: The amount of antibiotics resistant strains of Cdrynebacterium non diptheriae is large (89.0%) and non-similar in various species.


Assuntos
Antibacterianos/farmacologia , Corynebacterium/classificação , Corynebacterium/crescimento & desenvolvimento , Farmacorresistência Bacteriana/efeitos dos fármacos , Feminino , Humanos , Masculino
3.
Klin Lab Diagn ; 62(8): 502-506, 2017.
Artigo em Russo | MEDLINE | ID: mdl-30802399

RESUMO

The purpose of study is to analyze sensitivity of various species Corynebacterium non diphtheriaе to antibacterial pharmaceuticals. The strains of C. non diphtheriae are separated from patients with pathology of respiratory and urogenital tract and also from individuals subjected to preventive examination. The sensitivity to antibacterial pharmaceuticals was determined using technique of serial dilution in fluid growth medium on the basis values of minimal inhibitory concentration (mg per l). It is established that the most efficient antibacterial pharmaceuticals in the case of strains C. non diphtheriae proved to be Vancomycin, Cefazolin and Cefotaxime in general. In case of such particular species as С. pseudodiphtheriticum -- Cefazolin, Cefotaxime and Gentamycin; С.pseudotuberculosis -- Vancomycin, Cefazolin, Cefotaxime and Gentamycin; C. xerosis -- Cefotaxime; С.striatum -- Cefazolin and и Rifampicin. The least efficiency was manifested for strains C. non diphtheriae by Benzylpenicillin and Lincomycin in general. In case of such particular species as С. pseudodiphtheriticum and С. pseudotuberculosis -- Lincomycin and Erythromycin; C. xerosis and С. striatum -- Benzylpenicillin, Lincomycin and Erythromycin. In case of various species of C. non diphtheriae Сephalosporins (Cefotaxime and Cefazolin) can be recommended as pharmaceuticals of choice and Gentamycin and Vancomycin as reserve pharmaceuticals.


Assuntos
Antibacterianos/farmacologia , Corynebacterium/efeitos dos fármacos , Humanos , Testes de Sensibilidade Microbiana
4.
Klin Lab Diagn ; 62(9): 574-576, 2017.
Artigo em Russo | MEDLINE | ID: mdl-30807059

RESUMO

The article describes a clinical case of tuberculosis of of urinary tracts of a female patient with massive discharge of strain Corynebacterium riegelii from urogenital tract. The data of clinical laboratory examination of female patient are analyzed. The characteristics of isolated strain C. riegelii (high degree of isolation rate (106 and higher) expressed urease activity (decomposition of urease during 5 min), presence of hemolytic activity) with consideration for estimation of its antibiotics sensitivity. The etiologic significance of isolated species C. riegelii in development of infection process in urogenital tract is demonstrated.

5.
Klin Lab Diagn ; (4): 33-6, 2013 Apr.
Artigo em Russo | MEDLINE | ID: mdl-23984553

RESUMO

The article considers the results of study of formation and spread of MRSA in patients with suppurative focuses of stafillococus ethiology after application of antibacterial therapy. The antibacterial therapy applied to these patients used one of the following pharmaceuticals--cefazolin, lincomycin, gentamicin, oxampicin, ciprofloxacin, ofloxacin. All the strains of S. aureus ssp. aureus isolated from patients were tested on MRSA. Their phagovars were detected using international kit of phages for grouping of S. aureus ssp. aureus. The comparison of data received after analysis of resistance to oxacillin of strains and their phages isolated at the onset of disease and after applied treatment was carried out. The study established that against the background of applied antibacterial therapy in 10.7% of patients, MRSA formed and in 15.4% of patients, the change of initial strains of S. aureus ssp. aureus by MRSA strains of other phages groups was established. The presented results testified the need of obligatory testing of strains isolated from patients with staphylococcus infection on antibiotics resistance. The application of antibacterial therapy and its correction taking in account the laboratory data on antibiotics resistance and strict following the sanitary hygienic standards.


Assuntos
Resistência Microbiana a Medicamentos/genética , Staphylococcus aureus Resistente à Meticilina/patogenicidade , Infecções Estafilocócicas/tratamento farmacológico , Antibacterianos/farmacologia , Ciprofloxacina/farmacologia , Gentamicinas/farmacologia , Humanos , Staphylococcus aureus Resistente à Meticilina/classificação , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Staphylococcus aureus Resistente à Meticilina/genética , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Testes de Sensibilidade Microbiana , Oxacilina/farmacologia , Infecções Estafilocócicas/microbiologia
6.
Artigo em Russo | MEDLINE | ID: mdl-22830269

RESUMO

AIM: Characterize persistence properties and antibiotic sensitivity of Corynebacterium non diphtheriae circulating in Rostov-on-Don and Rostov Region. MATERIALS AND METHODS: DNase, anti-immunoglobulin activity, hemagglutinating activity, antagonistic properties and antibiotic sensitivity of Corynebacterium non diphtheriae strains isolated from patients with inflammatory diseases of urogenital tract, pregnant women and individuals undertaking prophylactic examination were studied. RESULTS: Lack of antagonistic interactions of C. non diphtheriae with members of opportunistic microorganisms, high anti-immunoglobulin activity against IgM and IgA, lack of hemagglutinating activity were established. Cefazolin and benzylpenicillin had the highest antibacterial activity against C. non diphtheriae, azithromycin and lincomycin--the lowest. CONCLUSION: Population level of C. non diphtheriae during urogenital tract disease diagnostics is necessary. Determination of their sensitivity to a wide specter of antibacterial preparations is reasonable for optimal selection of therapeutic agents.


Assuntos
Infecções por Corynebacterium/microbiologia , Corynebacterium/fisiologia , Infecções Urinárias/microbiologia , Sistema Urogenital/microbiologia , Adulto , Antibacterianos/farmacologia , Cefazolina/farmacologia , Corynebacterium/efeitos dos fármacos , Corynebacterium/patogenicidade , Infecções por Corynebacterium/tratamento farmacológico , Desoxirribonucleases/análise , Farmacorresistência Bacteriana/efeitos dos fármacos , Feminino , Hemaglutinação , Testes de Hemaglutinação , Humanos , Imunoglobulina A/análise , Imunoglobulina A/imunologia , Imunoglobulina M/análise , Imunoglobulina M/imunologia , Interações Microbianas/fisiologia , Testes de Sensibilidade Microbiana , Penicilina G/farmacologia , Gravidez , Federação Russa , Infecções Urinárias/tratamento farmacológico
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