1.
Antimicrob Agents Chemother
; 51(9): 3397-400, 2007 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17591849
RESUMO
Using the rabbit endocarditis model, we compared the activity of a new broad-spectrum cephalosporin, ceftaroline, with those of linezolid and vancomycin against methicillin-resistant Staphylococcus aureus. After a 4-day treatment, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus strains and appeared to be the most effective drug against a heterogeneous glycopeptide-intermediate S. aureus strain.