RESUMO
Incise drapes adhere well to skin and reduce bacterial migration into the wound. We took skin swabs before and after the application of incise drapes during 49 hip and knee arthroplasty procedures. Contamination was detected under incise drapes in four cases (8.1%) and consisted mainly of skin flora. We conclude that it is important to clean the skin again with antiseptics if the incise drape is removed by the surgeon.
Assuntos
Campos Cirúrgicos , Infecção da Ferida Cirúrgica/etiologia , Suturas , Ferimentos e Lesões/terapia , Contagem de Colônia Microbiana , Infecção Hospitalar/etiologia , Infecção Hospitalar/prevenção & controle , Humanos , Estudos Prospectivos , Campos Cirúrgicos/microbiologia , Infecção da Ferida Cirúrgica/prevenção & controleRESUMO
We present the case of a fit and well 20-year-old gentleman who presented to our emergency department with unilateral lower limb pain and swelling. Subsequent imaging revealed a left ilio-femoral deep vein thrombosis, with associated duplication of his inferior vena cava. He was treated conservatively with a heparin infusion, warfarin and compression therapy prior to being discharged following a short inpatient stay.
Assuntos
Veia Femoral , Veia Ilíaca , Malformações Vasculares/diagnóstico por imagem , Veia Cava Inferior/anormalidades , Trombose Venosa/etiologia , Veia Femoral/diagnóstico por imagem , Veia Femoral/patologia , Humanos , Veia Ilíaca/diagnóstico por imagem , Veia Ilíaca/patologia , Masculino , Radiografia , Malformações Vasculares/complicações , Veia Cava Inferior/diagnóstico por imagem , Trombose Venosa/diagnóstico , Adulto JovemRESUMO
This work examines the influence of modified gum karaya (MGK) on the oral bioavailability of a poorly water-soluble drug, nimodipine (NM), in comparison with that of gum karaya (GK). A cogrinding method was selected to prepare mixtures of NM and GK or MGK in a 1:9 ratio (NM:GK/MGK). Differential scanning calorimetry (DSC), Fourier transmission infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), solubility studies, and in vitro release studies were performed to characterize the properties of the cogrinding mixtures. No drug-carrier interactions were found, as confirmed by DSC and FT-IR studies. The XRD study revealed that the crystallinity of NM was identical in both the cogrinding mixtures and was decreased when compared to that of physical mixtures or pure NM. The in vitro release rate of NM from both cogrinding mixtures was significantly higher than that of physical mixtures or pure NM. The in vivo study revealed that the bioavailability of NM from pure drug was significantly lower when compared to the cogrinding mixtures. The oral bioavailability was found to be NM powder < cogrinding mixtures of NM and GK < cogrinding mixtures of NM and MGK < NM solution. It can be inferred from the above results that MGK, an economical carrier, could be used for the dissolution enhancement of NM.
