RESUMO
During November 2014-April 2015, a total of 165 case-patients with influenza virus A(H5N1) infection, including 6 clusters and 51 deaths, were identified in Egypt. Among infected persons, 99% reported poultry exposure: 19% to ill poultry and 35% to dead poultry. Only 1 person reported wearing personal protective equipment while working with poultry.
Assuntos
Virus da Influenza A Subtipo H5N1/patogenicidade , Influenza Humana/epidemiologia , Animais , Egito/epidemiologia , Epidemias/estatística & dados numéricos , Humanos , Virus da Influenza A Subtipo H5N1/genética , Influenza Aviária/transmissão , Influenza Humana/patologia , Influenza Humana/transmissão , Filogenia , Aves Domésticas/genética , Aves Domésticas/virologiaRESUMO
BACKGROUND: During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associated with this outbreak. METHODS: The U.S. Naval Medical Research Unit No.3 (NAMRU-3) was contacted by the Egyptian Ministry of Health and Population to perform diagnostic laboratory testing on eighteen conjunctival swabs from patients with conjunctivitis from El Daqahliya Governorate. Conjunctival swabs were tested by molecular methods for human adenovirus (HAdV) and enteroviruses (EV). Virus isolation was performed; the isolated virus was further characterized by molecular typing and phylogenetic analysis. RESULTS: The majority of the samples (17/18) were positive for enterovirus and all were negative for HAdV. Molecular typing and sequencing of the isolated virus revealed the presence of coxsackievirus A24 variant. Phylogenetic analysis based on the VP1 and 3C regions demonstrated that the Egyptian viruses belonged to Genotype IV and are closely related to coxsackievirus A24 variant, reported in a similar outbreak in China in August 2010. CONCLUSIONS: This study strongly suggests that coxsackievirus A24 variant was associated with the acute hemorrhagic conjunctivitis outbreak reported in Egypt in October 2010. There is a possibility that the same strain of CV-A24v was implicated in the AHC outbreaks in both China and Egypt in 2010.
Assuntos
Conjuntivite Hemorrágica Aguda/epidemiologia , Conjuntivite Hemorrágica Aguda/virologia , Enterovirus/isolamento & purificação , Adenovírus Humanos/genética , Adenovírus Humanos/isolamento & purificação , Surtos de Doenças , Egito/epidemiologia , Enterovirus/classificação , Enterovirus/genética , Feminino , Genótipo , Humanos , Dados de Sequência Molecular , Tipagem Molecular/métodos , FilogeniaRESUMO
The emergence of influenza viruses has raised awareness worldwide about influenza pandemic risks. Pandemic preparedness emphasizes development of risk communication and surveillance systems. The objective was to explore community classification of Acute Respiratory Illness (ARI) and health-seeking behaviors. Twenty in-depth interviews and 18 focus group discussions were conducted with caretakers in Egypt. The interviews were recorded, transcribed, and analyzed using the thematic analysis. ARI terminology contained few terms, usage of them was complex, and microorganism not part of illness explanation. Severe ARI was associated with social stigma. Homecare included extensive use of medications. In mild and severe ARI, health-seeking determinants varied. Classification of ARI parallels World Health Organization case definitions for ARI, facilitating risk communication. Homecare practices are social norms that can be expanded to include messages on ARI. Risk communication strategies and surveillance systems need to consider socio-cultural understanding of ARI.
