RESUMO
The present article describes an occurrence of eosinophilic airway inflammation of a 4-year-old female cynomolgus monkey in a vehicle control group of a routine toxicology study. Histologically, the airway lesion was characterized by prominent eosinophilic infiltrates, accompanied by mast cells, lymphocytes, and plasmacytes. The eosinophilic infiltrates were distributed throughout the airway: from trachea through respiratory bronchioles in the lung. The morphological feature of the lesion was indicative of an allergic airway disorder that can occur in humans with asthma. The present case is remarkable in that there is a paucity of reports on naturally occurring allergic airway disorders in nonhuman primates.
Assuntos
Eosinofilia/veterinária , Inflamação/veterinária , Macaca fascicularis , Doenças dos Macacos/imunologia , Doenças Respiratórias/veterinária , Animais , Eosinofilia/imunologia , Feminino , Histocitoquímica/veterinária , Inflamação/imunologia , Doenças Respiratórias/imunologiaRESUMO
An undifferentiated abdominal sarcoma was removed surgically from a koi carp. The diagnostic procedures, including radiography and computed tomography, and the procedures for general anaesthesia and the surgical approach for a celiotomy in a fish are described. The gross and microscopic appearance of the tumour is described and illustrated.
Assuntos
Neoplasias Abdominais/veterinária , Carpas/cirurgia , Doenças dos Peixes/cirurgia , Sarcoma/veterinária , Neoplasias Abdominais/diagnóstico por imagem , Neoplasias Abdominais/cirurgia , Animais , Diagnóstico Diferencial , Doenças dos Peixes/diagnóstico por imagem , Radiografia , Sarcoma/diagnóstico por imagem , Sarcoma/cirurgiaAssuntos
Doenças do Cão/diagnóstico , Hipergamaglobulinemia/veterinária , Imunossupressores/uso terapêutico , Plasmócitos/patologia , Pele/patologia , Alopecia/veterinária , Animais , Antineoplásicos Alquilantes/uso terapêutico , Antineoplásicos Hormonais/uso terapêutico , Biópsia/veterinária , Ciclofosfamida/uso terapêutico , Doenças do Cão/terapia , Cães , Edema/veterinária , Eletroforese/veterinária , Hipergamaglobulinemia/diagnóstico , Hipergamaglobulinemia/terapia , Hiperpigmentação/veterinária , Imuno-Histoquímica , Linfonodos/patologia , Masculino , Melfalan/uso terapêutico , Prednisona/uso terapêutico , gama-Globulinas/análiseRESUMO
A group of Walker Hounds and Beagles that were fed a diet of table scraps were examined because of slow, progressive loss of vision. Clinical and microscopic features of the disease were correlated to the dogs' micronutrient status. Sensory retinal degeneration, predominantly in the central tapetal fundus, was found in all dogs, and severity of changes varied with age of the dog. Plasma, serum, and tissue concentrations of vitamin E were low in affected dogs (10 to 40% of control values). Lipofuscin accumulation was found on microscopic examination in retinal pigment epithelium, smooth muscle cells of the intestinal tract, and neurons of the CNS. Findings were consistent with nutritional vitamin E deficiency and oxidative injury to photoreceptors of the retina. Changes in these dogs were similar to those described for central progressive retinal atrophy and equine lower motor neuron disease, suggesting these diseases may share a common pathogenesis to vitamin E deficiency.
Assuntos
Dieta/veterinária , Doenças do Cão/etiologia , Retina/patologia , Degeneração Retiniana/veterinária , Deficiência de Vitamina E/veterinária , Fatores Etários , Animais , Dieta/efeitos adversos , Doenças do Cão/patologia , Cães , Angiofluoresceinografia/veterinária , Fundo de Olho , Lipofuscina/análise , Retina/química , Retina/ultraestrutura , Degeneração Retiniana/etiologia , Degeneração Retiniana/patologia , Vitamina E/sangue , Deficiência de Vitamina E/complicações , Deficiência de Vitamina E/patologiaRESUMO
An 8-year-old Thoroughbred gelding was admitted for evaluation of chronic lameness of the left scapulohumeral joint of 3 months' duration. Radiography revealed a radiolucent lesion with the proximal portion of the humerus in the area of the metaphysis. Scintigraphy confirmed radiographic findings, with an increased uptake of technetium Tc 99m medronate in the proximal portion of the left humerus. A preliminary diagnosis of humeral fracture was made. Two weeks later, the horse was readmitted for clinical signs of respiratory distress. Radiographic and ultrasonographic evaluation revealed masses within the thoracic and abdominal cavities. The diagnosis was changed to neoplasm with multiple metastases. Because of the unfavorable prognosis, the horse was euthanatized. Necropsy findings confirmed an aggressive neoplasm. Special histochemical stains, immunohistochemistry, and electron microscopy were required to characterize the neoplasm as an anaplastic fibrosarcoma. Findings in this horse illustrate the importance of considering neoplasia, resulting in bone lesions, as a possible cause of chronic lameness in horses.
Assuntos
Neoplasias Ósseas/veterinária , Fibrossarcoma/veterinária , Doenças dos Cavalos/etiologia , Coxeadura Animal/etiologia , Neoplasias Pulmonares/veterinária , Derrame Pleural/veterinária , Animais , Neoplasias Ósseas/complicações , Neoplasias Ósseas/secundário , Fibrossarcoma/complicações , Fibrossarcoma/secundário , Cavalos , Úmero/diagnóstico por imagem , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/secundário , Masculino , Derrame Pleural/etiologia , Cintilografia , Articulação do OmbroRESUMO
OBJECTIVE: To characterize the pathogenic potential of a unique Borrelia isolate obtained from a dog from Florida (FCB isolate). DESIGN: Prospective experimental infection. ANIMALS: 32 preweanling Swiss Webster mice and 12 adult male Hartley guinea pigs were injected intraperitoneally with 10(5) spirochetes. PROCEDURE: Mice were used as controls and blood recipients, and at 3- to 4-day intervals, 1 control mouse and 2 infected mice were necropsied, tissues were cultured, and a recipient mouse was inoculated with blood. Guinea pigs were randomized to 4 groups and inoculated intradermally with 10(0), 10(2), 10(3), or 10(4) spirochetes. For 48 days, clinical, hematologic, serologic, and microbiologic tests were performed on them, after which they were necropsied. RESULTS: In mice, spirochetemia was detectable between postinoculation days (PID) 3 and 13, and seroreactivity to homologous antigen was detectable during PID 10 through 31. Compared with control mice, infected mouse spleens were 2 to 3 times larger. Histologic lesions included lymphoid hyperplasia, neutrophilic panniculitis, epicarditis, and myocarditis, with intralesional spirochetes detected from PID 3 through 6. During PID 10 through 31, nonsuppurative epicarditis developed. Signs of illness and hematologic abnormalities were not observed in guinea pigs, despite isolating spirochetes from blood during PID 7 to 27. When necropsied on PID 48, histologic lesions included lymphoid hyperplasia and lymphocytic plasmacytic epicarditis. CONCLUSIONS: The FCB isolate causes spirochetemia, lymphoid hyperplasia, dermatitis, and myocardial injury in Swiss Webster mice and can be transmitted by blood inoculation. In Hartley guinea pigs, the isolate causes spirochetemia, lymphoid hyperplasia, and epicarditis. Documentation of disease in mice, guinea pigs, and, presumably, dogs raises the level of concern that the FCB isolate might be pathogenic for man and other animal species.