Dental caries prevalence in relation to the cardiovascular diseases: cross-sectional findings from the Iranian kurdish population.

OBJECTIVE: Oral and dental health (ODH) is a significant public health concern globally, affecting billions of people. This cross-sectional study aimed to examine the prevalence of dental caries using the DMFT index and investigate its relationship with cardiovascular diseases in the Iranian Kurdish population. METHODS: A total of 3,996 individuals aged 35-70 years were included from the Dehgolan prospective cohort study (DehPCS). Clinical examinations were performed to assess decayed (DT), missing (MT) and filled (FT) teeth (DMFT index). Data on demographics, socioeconomic status, medical history, oral hygiene practices were also collected. Cardiovascular disease (CVD) history was self-reported via questionnaires assessing heart disease, heart attack and stroke. Logistic regression was used to assess associations between oral health indicators and self-reported CVD, adjusting for potential confounders. RESULTS: The mean DMFT score was 18.18 ± 19, indicating a high oral disease burden. Specifically, 60.04% had DT, 37.82% had more than 16 MT, and 38.83% had FT. Only 13.21% reported flossing regularly and 43.17% brushed less than daily, showing suboptimal oral hygiene. The overall CVD prevalence was 9.21%. Individuals with high DMFT (≥ 14) scores had approximately two times higher CVD prevalence than those with low DMFT. DMFT decreased by 10.23% with increase in education level, and by 5.87% as economic status increased In adjusted analyses, high DMFT scores (OR = 1.5, 95%CI: 1.2-1.9) and MT (OR = 1.5, 95%CI: 1.1-2.1) were associated with 50-150% increased odds of CVD, though associations weakened after adjusting for age. Among men, DMFT remained a significant predictor for CVD after age adjustment, with an odds ratio of 2.37 (95% CI: 1.22-4.60). CONCLUSION: This population had substantial oral disease and poor oral hygiene. Higher DMFT scores and MT positively correlated with increased CVD prevalence. Promoting preventive oral care and health education could help reduce dental issues and potentially lower CVD risk. Further research is needed to clarify biological mechanisms linking oral and systemic health.

Prevalence of linezolid resistance in Streptococcus pneumoniae isolates: a systematic review and meta-analysis.

Aim: This study aimed to understand the current level of linezolid (LNZ) resistance in Streptococcus pneumoniae isolates reported over the past 10 years. Material & methods: An electronic search was conducted for the following keywords: ((Streptococcus pneumoniae [title/abstract]) OR (Pneumococcus [title/abstract]) OR (Pneumococci [title/abstract]) AND (linezolid [title/abstract]) OR (Zyvox [title/abstract])) OR (Zyvoxid [title/abstract])). Result: Out of all the studies, 80 had a cross-sectional design, while 11 followed a cohort approach. The prevalence of LNZ resistance among S. pneumoniae isolates ranged from 0% to 4.86%. Discussion: Urgent, high-powered, randomized, controlled trials with participants from endemic regions are needed to gain a comprehensive understanding of the impact on and significance of LNZ treatment to patients.

Psychometric properties of the Persian version of the Fleishman Job Analysis Survey (FJAS).

BACKGROUND: Job analysis is one of the most important and widely used processes to determine job duties, identify and reduce potential risks, and specify the skills and facilities required for each job at the highest level of occupational safety and health. OBJECTIVE: This study aimed to perform psychometric analyses of the Persian version of the Fleishman Job Analysis Survey (FJAS). METHODS: A cross-sectional study was conducted among 31 drivers. Participants were selected by random sampling. Ten occupational health and ergonomics experts confirmed the validity of the survey. First, we calculated the survey's CVR and CVI. Then, we used ICC and Cronbach's alpha coefficients to evaluate the survey's reliability. Data analysis utilized SPSS 21. RESULTS: 78% of the participants were male and 22% were female. The mean age±SD of the participants was 39.1±11.82 years. The reliability and validity of the short version survey showed that the value of ICC and Cronbach's alpha coefficient was 0.96, and CVR was 0.75. Moreover, the values of CVI for simplicity, clarity, and relevance were 0.87, 1, and 0.73, respectively. The long version's ICC and CVR were 0.96 and 0.97, respectively. Simplicity, clarity, and relevance CVI scores were 0.9, 0.94, and 0.95. CONCLUSION: The results of this study showed that the Persian version of the Fleischman Job Analysis Survey has the necessary validity and reliability for job analysis, so it can be used for driving professional or research purposes. Moreover, this survey is an effective tool for obtaining accurate and complete knowledge of job tasks and requirements.

The potential impact of emotionally loaded stimuli on over/under-estimating neutral situations among power plant control-room operators.

BACKGROUND: Human emotions vary on a contextual basis. The significance of emotions becomes even more salient in Control Room Operators (CROs) in power plants. OBJECTIVE: This study investigated the effects of emotionally loaded pictures on over/underestimating neutral situations. METHODS: Twenty CROs voluntarily enrolled in the present study. Twenty-one blocks were considered, including ten emotionally loaded and 11 neutral blocks. The stimuli were alternatively submitted to subjects in random order. Each block comprised 13 images from the International Affective Picture System (IAPS), which were shown for 5 seconds. Subjects were required to complete the Self-Assessment Manikin (SAM) after exposure to the first and the last neutral blocks, which were identical. RESULTS: Our analyses showed significant differences between IAPS arousal and SAM1 and SAM2 arousal ratings (p SAM1&IAPS = 0.00, p SAM2&IAPS = 0.02). There was no significant relationship between the first and the second arousals, and emotionally loaded images corresponded to no significant difference in terms of valence. CONCLUSION: The findings suggested that the participants overestimated neutral situations compared with IAPS only in arousal level. Furthermore, CROs can still retain their ability to assess neutral situations in the case of viewing emotional stimuli, especially in valence level, at least half an hour after the first rating. A study design with pure negative/positive and high arousal levels may still provide even more significant results.

Tetrazol-Cu(i) immobilized on nickel ferrite catalyzed green synthesis of indenopyridopyrimidine derivatives in aqueous media.

After the initial study of different protocols in the synthesis of indeno[2',1':5,6]pyrido[2,3-d]pyrimidines, herein, a new method is presented using cheaper and more accessible starting materials to produce high-efficiency products. In this protocol, the novel nanocatalyst is very effective in the progression of the reaction and increasing the efficiency. This green approach in aqueous media has several advantages as compared with other methods, such as easier work-up, very mild reaction conditions, reusability of the catalyst, and eco-friendliness. The products of this four-component condensation were evaluated using IR, 1H NMR, 13C NMR spectra, and C. H. N. analyses, and the catalyst structure was confirmed by FT-IR, XRD, SEM, EDX, TGA and VSM techniques.

Psychometric properties of the persian language version of the system usability scale.

BACKGROUND: The System Usability Scale (SUS) is a widely used self-administered instrument for evaluating the usability of a wide range of products and services. The aims of this descriptive-methodological study were to develop and investigate the psychometric properties of the Iranian version of the SUS. METHODS: The study was conducted among 202 university students from the Tabriz University of Medical Sciences, Iran. Content validity was evaluated by a panel of 10 experts. Construct validity was assessed by exploratory and confirmatory factor analyses. The internal consistency and test-retest reliability were assessed by Cronbach's alpha and Intraclass Correlation Coefficient (ICC), respectively. Additionally the feasibility of the measure was judged by ceiling and floor effect. RESULTS: Content validity of the short form of Iranian SUS was established. Factor analyses supported the conceptual uni-dimensionality, and thus confirmed the construct validity of the measure. The internal consistency (α = 0.79) and test retest reliability (ICC = 0.96) were both approved and there was also no ceiling nor floor effect. CONCLUSIONS: The findings support the use of SUS for both practical and research settings in Iranian population.

Structure-activity relationship for Fe(III)-salen-like complexes as potent anticancer agents.

Quantitative structure activity relationship (QSAR) for the anticancer activity of Fe(III)-salen and salen-like complexes was studied. The methods of density function theory (B3LYP/LANL2DZ) were used to optimize the structures. A pool of descriptors was calculated: 1497 theoretical descriptors and quantum-chemical parameters, shielding NMR, and electronic descriptors. The study of structure and activity relationship was performed with multiple linear regression (MLR) and artificial neural network (ANN). In nonlinear method, the adaptive neuro-fuzzy inference system (ANFIS) was applied in order to choose the most effective descriptors. The ANN-ANFIS model with high statistical significance (R (2) train = 0.99, RMSE = 0.138, and Q (2) LOO = 0.82) has better capability to predict the anticancer activity of the new compounds series of this family. Based on this study, anticancer activity of this compound is mainly dependent on the geometrical parameters, position, and the nature of the substituent of salen ligand.