Applications of artificial intelligence in dentomaxillofacial imaging-a systematic review.

BACKGROUND: Artificial intelligence (AI) technology has been increasingly developed in oral and maxillofacial imaging. The aim of this systematic review was to assess the applications and performance of the developed algorithms in different dentomaxillofacial imaging modalities. STUDY DESIGN: A systematic search of PubMed and Scopus databases was performed. The search strategy was set as a combination of the following keywords: "Artificial Intelligence," "Machine Learning," "Deep Learning," "Neural Networks," "Head and Neck Imaging," and "Maxillofacial Imaging." Full-text screening and data extraction were independently conducted by two independent reviewers; any mismatch was resolved by discussion. The risk of bias was assessed by one reviewer and validated by another. RESULTS: The search returned a total of 3,392 articles. After careful evaluation of the titles, abstracts, and full texts, a total number of 194 articles were included. Most studies focused on AI applications for tooth and implant classification and identification, 3-dimensional cephalometric landmark detection, lesion detection (periapical, jaws, and bone), and osteoporosis detection. CONCLUSION: Despite the AI models' limitations, they showed promising results. Further studies are needed to explore specific applications and real-world scenarios before confidently integrating these models into dental practice.

Assessment of CBCT gray value in different regions-of-interest and fields-of-view compared to Hounsfield unit.

OBJECTIVES: Different factors can affect the discrepancy between the gray value (GV) measurements obtained from CBCT and the Hounsfield unit (HU) derived from multidetector CT (MDCT), which is considered the gold-standard density scale. This study aimed to explore the impact of region of interest (ROI) location and field of view (FOV) size on the difference between these two scales as a potential source of error. METHODS: Three phantoms, each consisting of a water-filled plastic bin containing a dry dentate human skull, were prepared. CBCT scans were conducted using the NewTom VGi evo system, while MDCT scans were performed using Philips system. Three different FOV sizes (8 × 8 cm, 8 × 12 cm, and 12 × 15 cm) were used, and the GVs obtained from eight distinct ROIs were compared with the HUs from the MDCT scans. The ROIs included dental and bony regions within the anterior and posterior areas of both jaws. Statistical analyses were performed using SPSS v. 26. RESULTS: The GVs derived from CBCT images were significantly influenced by both ROI location and FOV size (p < 0.05 for both factors). Following the comparison between GVs and HUs, the anterior mandibular bone ROI represented the minimum error, while the posterior mandibular teeth exhibited the maximum error. Moreover, the 8 × 8 cm and 12 × 15 cm FOVs resulted in the lowest and highest degrees of GV error, respectively. CONCLUSIONS: The ROI location and the FOV size can significantly affect the GVs obtained from CBCT images. It is not recommended to use the GV scale within the posterior mandibular teeth region due to the potential for error. Additionally, selecting smaller FOV sizes, such as 8 × 8 cm, can provide GVs closer to the gold-standard numbers.

Cone Beam CT Analysis of Haller Cells: Prevalence and Relationship with Orbital Floor Dehiscence.

Materials and Methods: CBCT images of 120 patients were interpreted in coronal plane for the presence of Haller cells and orbital floor dehiscence. The prevalence of Haller cell, presence of dehiscence, unilateral, or bilateral frequency were assessed. In addition, the size was categorized in three groups of small, medium, and large. Chi-square and Cochran-Mantel-Haenszel tests were used for statistical analysis of the data, and p < 0.05 was considered to be significant. Results: A total of 51 male and 69 female with mean ± SD age of 38.84 ± 68.14 were assessed. The overall prevalence of Haller cells was 56.7%, of which 44 (64.7%) were unilateral and 24 were bilateral (35.3%). The majority of the cells (70.7%) were seen in medium (2-4 mm) sized. There was a significant association between Haller cells and orbital floor dehiscence (p ≤ 0.001). Conclusion: The prevalence of Haller cells was remarkably high and the presence of Haller cells was strongly associated with ipsilateral orbital floor dehiscence. Based on the findings of this study, CBCT can be useful in delineation of the bony anatomy of sinonasal complex.

The efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva: A systematic review.

This systematic review aimed to evaluate existing randomized controlled trials (RCT) and cohort studies on the efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva. Searches with pertinent search terms were conducted in PubMed, MEDLINE, Scopus, and Web of Science databases for relevant records published up to Oct 15, 2022. Google Scholar and ProQuest were searched for grey literature. Manual searches were conducted as well for any pertinent articles. The protocol was prospectively registered at PROSPERO (CRD42022324894). Eligible studies were critically appraised for risk of bias and quality of evidence to assess the efficacy of mouthwash in reducing the SARS-CoV-2 viral load in human saliva. Eleven studies were included. The effect on viral load using various types of mouthwash was observed, including chlorhexidine (CHX), povidone-iodine (PI), cetylpyridinium chloride (CPC), hydrogen peroxide (HP), ß-cyclodextrin-citrox mouthwash (CDCM), and Hypochlorous acid (HCIO). Eight articles discussed CHX use. Five were found to be significant and three did not show any significant decrease in viral loads. Eight studies reviewed the use of PI, with five articles identifying a significant decrease in viral load, and three not showing a significant decrease in viral load. HP was reviewed in four studies, two studies identified significant viral load reductions, and two did not. CPC was reviewed in four studies, two of which identified significant viral load reductions, and two did not. CDCM was reviewed in one article which found a significant decrease in viral load reduction. Also, HCIO which was evaluated in one study indicated no significant difference in CT value. The current systematic review indicates that based on these eleven studies, mouthwashes are effective at reducing the SARS-CoV-2 viral load in human saliva. However, further studies should be performed on larger populations with different mouthwashes. The overall quality of evidence was high.

Effect of the Field of View Size on CBCT Artifacts Caused by the Presence of Metal Objects in the Exomass.

Materials and Methods: In this in vitro experimental study, titanium implants, teeth with cobalt-chromium (Co-Cr) intracanal posts, and teeth with mesio-occluso-distal (MOD) amalgam restorations were placed in an empty socket of the extracted third molar of a human mandible. These metallic materials were differently arranged in the exomass (zone outside of the FOV). A polypropylene tube containing dipotassium phosphate was placed in the empty socket of the right canine tooth in a dry human mandible. CBCT scans were taken with a NewTom VGI (Verona, Italy) scanner using a 6 × 6 cm and an 8 × 8 cm FOV. The histogram tool of OnDemand software (Cybermed, Seoul, Korea) was used to select circles with a 1.5 mm diameter as the (ROI) at the center of the homogenous solution of dipotassium phosphate tube on the axial plane. The mean gray value (GV) and its standard deviation (SD) in the region of interest (ROI) were calculated (P > 0.05). The data were analyzed by SPSS 26. Results: The reduction in the size of the FOV significantly decreased the mean GV (P < 0.001). Metal objects in the exomass significantly decreased the mean GV (P < 0.001), and minimum mean GV and maximum SD were recorded for amalgam, followed by Co-Cr intracanal posts, and titanium implants. The unilateral presence of a metal object was associated with a higher mean GV and lower SD (P < 0.001). Conclusion: Using a smaller FOV increases the size of the exomass, which may negatively affect the image quality. Metal objects in the exomass decrease the GV of CBCT scans and adversely affect the image quality.

Quantitative Assessment of Posterior Maxillary Arch for Orthodontic Miniscrew Insertion Using Cone Beam Computed Tomography: A Cross-Sectional Analysis.

Methods and Materials: Cone beam computed tomography records of 35 patients (70 quadrants) from maxilla were evaluated. The images were analyzed using the NNT viewer software (version 23). The measurements were made on axial sections at 2, 4, 6, and 8 mm from CEJ. The optimal sites were defined in terms of mesiodistal palatal or buccal interradicular distance, alveolar cortical bone thickness, and palatal or buccal safe depth of the bone for miniscrew insertion. Descriptive statistics, paired t-test, and repeated measure ANOVA were used to analyze the data. Results: The mean buccal interradicular distance was the lowest between first and second molar (2.44 mm) and the highest between first and second premolar (3.28 mm). The mean palatal interradicular distance was the lowest between first and second premolar (3.64 mm) and the highest between second premolar and first molar (5.30 mm). The mean buccal safe depth was the lowest between canine and first premolar (1.96 mm) and the highest between first and second molar (2.61 mm). The mean palatal safe depth was the lowest between second premolar and first molar (3.35 mm) and the highest between first and second molar (3.56 mm). The thinnest and thickest buccal cortical thicknesses were detected on canine and first molar (1.04 mm) and on the second premolar and second molar (1.56 mm). Conclusion: The quantity and quality of the maxillary alveolar process is an important factor to decide where to insert the orthodontic miniscrews, necessitating careful preoperative evaluation.

ASSESSMENT OF OCCUPATIONAL RADIATION DOSE FROM CAMERA MODEL INTRAORAL HANDHELD X-RAY DEVICE WITHOUT STRAY RADIATION PROTECTION SHIELD.

The aim of this study was to assess the occupational exposure from portable X-ray device without stray radiation protection shield measured using thermoluminescent dosemeters (TLDs). A total of 108 intraoral periapical radiographies of six sextants were performed. The TLDs were located on right index finger and left palm, between the pupils of the eyes at the edges of the Nasion point, Manubrium of Sternum bone and genital area. The detected mean doses per procedure were 70, 99, 60, 51, 51 and 58 µSv in the right finger, left palm, level of the Nasion point, under left clavicle, above the sternum manubrium and at the gonad area, respectively. Maximum number of radiographic images that the operator is allowed to perform depends on eye exposure and in accordance with International Commission on Radiological Protection is 0.16 (0.12-0.23) per hour or 1.28 (0.96-1.84) per day.

Clinical, Radiographic and Histological Assessments of a Rare Case of Intraosseous Arteriovenous Malformation in Maxilla Occurred During Pregnancy: A Case Report.

Objective: Intraosseous Arteriovenous malformation (AVM) is a vascular hamartoma with almost 50% of cases occurring in the head and neck. These lesions are of great importance as they may cause massive bleeding during tooth extraction and surgeries. Case report : A 33 year old female complained of swelling and gingival bleeding on the right side of the maxilla and hard palate. The swelling was noticed during pregnancy and the patient underwent a surgical excision 6 months after labor. The specimen was submitted for histological examination. An intraosseous AVM presenting in maxilla was diagnosed. Conclusion: Although rare, intraosseous AVM may occur. The role of pregnancy and hormonal changes is still controversial. Clinical, radiographic and histological characteristics of AVM should be thoroughly assessed before surgical excision.

The occurrence of dental implant malpositioning and related factors: A cross-sectional cone-beam computed tomography survey.

PURPOSE: Dental implants are widely used for the rehabilitation of edentulous sites. This study investigated the occurrence of dental implant malpositioning as shown on post-implantation cone-beam computed tomography (CBCT) and to identify related factors. MATERIALS AND METHODS: Samples with at least 1 malpositioned dental implant were collected from a central radiology clinic in Tehran, Iran from January 2017 to January 2019. Variables such as demographic characteristics, length and diameter of implants, type of implant, sites of implant insertion, different types of implant malpositioning problems (cortical plate perforation, interference with anatomical structures), angulation of the implant, and the severity of malpositioning were assessed. In addition, the incidence of implant fracture and over-drilling was evaluated. Data were statistically analyzed using the chi-square test, 1-sample t-test, and Spearman correlation coefficients. RESULTS: In total, 252 patients referred for implant postoperative CBCT evaluations were assessed. The cases of implant malpositioning included perforation of the buccal cortical plate (19.4%), perforation of the lingual cortical plate (14.3%), implant proximity to an adjacent implant (19.0%), implant proximity to an adjacent tooth (3.2%), interference with anatomical structures (maxillary sinus: 18.3%, mandibular canal: 11.1%, nasal cavity: 6.3%, mental foramen: 5.6%, and incisive canal: 0.4%). Implant fracture and over-drilling were found in 1.6% and 0.8% of cases, respectively. Severity was categorized as mild (9.5%), moderate (35.7%), severe (37.7%), and extreme (17.1%), and 52.4% of implants had inappropriate angulation. CONCLUSION: CBCT imaging is recommended for detecting dental implant malpositioning. The most common and severe type of malpositioning was buccal cortex perforation.

Large Rhinolith Mimicking Atypical Odontogenic Pain: Case Report and Brief Review of the Literature.

Rhinoliths are rare calcified entities in the nasal fossa, frequently originating around a nidus near the midway point in the inferior meatus, where the passage is the narrowest. They can be clinically asymptomatic and undetected for years. In this study, we present a rare case of large rhinolith mimicking atypical odontogenic pain in a 40-year-old Caucasian female in the left nasal cavity. The lesion was detected in the CBCT and removed uneventfully.

Clinical, Imaging and Histopathology of Angioleiomyoma of the Buccal Cheek.

Angioleiomyoma is a benign neoplasia originating from vascular smooth muscle and very uncommon in the oral cavity. In this report, we present a rare case of angioleiomyoma in oral cavity in a 46-year-old female buccal cheek and discuss the clinical, histological, and immunohistochemical characteristics. As the treatment of choice is the complete excision, the lesion was excised under local anesthesia with no further complications. In addition, a brief update on other reported cases of angiomyoma in the oral cavity is further discussed.

Anatomical variations in the interforaminal regions of candidates for implant-assisted overdentures: a cross-sectional CBCT analysis.

Implant-supported overdentures are becoming a common treatment modality, providing functional and esthetic results for patients in need of full-mouth rehabilitation. Because anatomical variations in the residual ridge affect treatment planning, the aim of this retrospective study was to present quantitative descriptions of the interforaminal region by evaluating a large series of cone beam computed tomographic (CBCT) images of the mandibles of edentulous patients in need of anterior dental implants. The sample included a total of 180 CBCT scans (360 sites) of patients requiring endosseous implant placement in the anterior region of the mandible for implant-assisted overdentures. The CBCT images were evaluated for parameters such as ridge height, width, angulation, and undercuts; crestal height; and corticocancellous bone ratios. The statistical analyses included the independent-samples t test and chi-square analysis. The mean (SD) ridge height was 18.16 (0.36) mm on the right side and 17.79 (0.38) mm on the left side and was significantly greater in men than in women (P = 0.02). Men also had a significantly greater cortical crest height than women (P = 0.01). The prevalence of ridge undercuts in the buccal cortex was 10.0% on the right side and 7.2% on the left side, and these undercuts had mean (SD) depths of 1.52 (0.62) mm and 1.48 (0.60) mm on the right and left sides, respectively. The ratio of cortical bone to cancellous bone was significantly greater in men than in women (P = 0.03). The mean (SD) ridge angle was 14.51 (6.54) degrees on the right side of the mandible and 13.05 (6.47) degrees on the left side, a statistically significant difference (P = 0.00). Moderate positive correlations were detected between the patient age and both the ridge widths (P = 0.00) and cancellous bone widths (P = 0.01). Moderate negative correlations were detected between the patient age and both ridge height and cortical crest height (P = 0.00). The widest ranges of variation belonged to ridge angle and ridge height, respectively, but the differentiation between the right and left sides was clinically insignificant. Knowledge of the patient's anatomical variations will allow the clinician to formulate an individualized treatment plan.

Prevalence of Nasal Septum Deviation Using Cone-Beam Computed Tomography: A Cross-Sectional Study.

BACKGROUND AND AIM: Nasal septum deviation (NSD) increases the chance of nasal obstruction, sinusitis, and upper airway and middle ear infections and can affect vocal cord activity, beauty, and breathing. The present study investigated the prevalence of NSD and its relation to gender, age, and history of trauma using cone-beam computed tomography (CBCT). SUBJECTS AND METHODS: This cross-sectional study was performed on the data from CBCT examinations of 386 patients referred to two oral and maxillofacial radiology centers in Tehran, Iran, from January 2016 to January 2017. The presence of NSD and its type according to the Mladina's classification were evaluated. The effect of age, gender, and history of trauma on the prevalence of NSD was considered using a logistic regression. RESULTS: 86.6% (confidence interval = 0.81, 0.91) of the patients showed NSD. The prevalence was 19.4% type 1, 6.2% type 2, 20.7% type 3, 5.4% type 4, 4.4% type 5, 0.3% type 6, and 30.3% with type 7. The logistic regression indicated that the chance of deviation of nasal septum increased with age and every 10-year increase in age increased the odds of septal deviation by 0.32 (P < 0.001 and odds ratio = 1.032). Gender (P = 0.094) and history of trauma (P = 0.79) had no effects on the chance of deviation of nasal septum. CONCLUSION: This study showed that the frequency of NSD was 86.6%, with type 7 being the most common type, followed by type 3 and 1. NSD showed no association with trauma and gender, and the increase in age increases the chance of NSD.

Laser pulpotomy-an effective alternative to conventional techniques-a systematic review of literature and meta-analysis.

The aim of this systematic review and subsequent meta-analysis was to elaborate the efficacy of laser pulpotomy over the formocresol pulpotomy of human primary teeth. Published materials in the MedLine were looked for through "PUBMED" and "PUBMED CENTRAL". The MESH terms of "Laser", "Pulpotomy", "Primary teeth", and "Children" were used to carry the search from the years 1999 to 2017. Collected data were assessed by four investigators using inclusion and exclusion criteria in order to select those studies with precise method targeted. Only clinical trials on all types of lasers were included for this systematic reviews but only four articles were used for the meta-analysis as the rest did not meet the requirements. Statistical analysis was conducted to see the differences. Seventeen articles completely fulfilled the inclusion criteria of this study. In general, high clinical, radiographic, and histopathological success rates were reported in laser groups in comparison to other assessed methods. Meta-analysis indicated that except at 36 months, in all other time intervals, Laser proved better or close results to formocresol. At 36 months, laser showed better clinical results. Laser may be considered as an adjuvant alternative for vital pulp therapy on human primary teeth but due to the limited number of high-quality clinical research articles on laser-assisted pulpotomy, various types of laser application methods, and different follow-up periods, reaching a net consensus is still challenging.

Application of selected scaffolds for bone tissue engineering: a systematic review.

PURPOSE: The current systematic review investigated the results of application of some of the most commonly used scaffolds in conjugation with stem cells and growth factors in animal and clinical studies. METHODS: A comprehensive electronic search was conducted according to the PRISMA guidelines in NCBI PMC and PubMed from January 1970 to December 2015 limited to English language publications with available full texts. In vivo studies in relation to "bone healing," "bone regeneration," and at least one of the following items were investigated: allograft, ß-tricalcium phosphate, deproteinized bovine bone mineral, hydroxyapetite/tricalcium phosphate, nanohydroxyapatite, and composite scaffolds. RESULTS: A total of 1252 articles were reviewed, and 46 articles completely fulfilled the inclusion criteria of this study. The highest bone regeneration has been achieved when combination of all three elements, given scaffolds, mesenchymal stem cells, and growth factors, were used. Among studies being reported in this review, bone marrow mesenchymal stem cells are the most studied mesenchymal stem cells, ß-tricalcium phosphate is the most frequently used scaffold, and platelet-rich plasma is the most commonly used growth factor. CONCLUSION: The current review aimed to inform reconstructive surgeons of how combinations of various mesenchymal stem cells, scaffolds, and growth factors enhance bone regeneration. The highest bone regeneration has been achieved when combination of all three elements, given scaffolds, mesenchymal stem cells, and growth factors, were used.