RESUMO
Merkel cell carcinoma is a rare, aggressive neuroendocrine tumor of the skin commonly seen in the elderly on the head, neck and extremities, with a predisposition for local regional and distant spreading. A case of Merkel cell carcinoma occurred in a woman treated with immunosuppressive therapy for myasthenia gravis, is described and the possibility of a link between the immunosuppressive and/or oncogenic therapy and this tumor is suggested.
Assuntos
Carcinoma de Célula de Merkel/complicações , Miastenia Gravis/complicações , Neoplasias Cutâneas/complicações , Idoso , Carcinoma de Célula de Merkel/patologia , Evolução Fatal , Feminino , Humanos , Imunossupressores/efeitos adversos , Miastenia Gravis/tratamento farmacológico , Neoplasias Cutâneas/patologiaRESUMO
Twenty eight patients with heterozygous familial hypercholesterolemia were treated with mevalonic acid (an inhibitor of cholesterol synthesis) for 45 days. Patients received a daily dose of 750 to 1500 mg mevalonic acid depending on plasma cholesterol levels. Results showed a significant reduction in cholesterol values whereas no significant difference was observed in HDL cholesterol and triglyceride levels.