[Determination of antithrombin III (chromogenic substrates) and FDP in women in treatment with oral estroprogestin agents]. / Valutazione dell'antitrombina III (substrati cromogeni) e FDP in donne in trattamento con estroprogestinici orali.

In 280 women, in fertile age, 133 of whom represented the control group, FDP and antithrombin III with the method of chromogenic substrates were determined. In 147 women, who were taking, for variable period of time, oral estroprogestinic drugs, a significant diminution of antithrombin III was found. No significant differences for FDP were observed.

PIP: 147 women, aged 17-48, on oral contraception (OC) for a period of 3 months-11 years, were observed to study changes in the level of antithrombin 111 and fibrinogenous degradation products (FDP). The patients were compared to 133 controls, who had undergone the same tests. A significant decrease in the concentration of antithrombin 111 was found in most patients, ex especially in those who had been on OCs for a short period of time; the type of contraceptive agent used did not seem to be relevant. No significant differences were found in FDP levels.