COMPARATIVE ANALYSIS OF THE EFFICACIES OF BOTULINOTOXIN A THERAPY AND FRACTIONAL RADIO-FREQUENCY-LIFTING IN THE TREATMENT OF PRIMARY HYPERHYDROSIS.

Hyperhydrosis (HH) is a pathology of eccrine gland which is manifested by excessive sweating on the skin. It has a significant negative impact on an individual's quality of life (QoL). Primary HH is the most common idiopathic condition which is mostly localized. Botulinum toxin A therapy (BTX) treatment is one of the proven, minimally invasive methods for HH treatment; however, minimally invasive fractional RF-lifting with microneedles for primary HH is of great interest of researchers. The aim of our study was to compare the effectiveness of fractional RF-lifting with microneedles and botulinum toxin-A treatment methods in people with primary HH and to determine the role of these methods in HH management tactics based on the analysis. After signing the consent agreement 60 patients with HH participated in the study. 30 patients were selected for BTX (group 1), another 30 participants - for RF-lifting with microneedles (group 2). Target areas of treatment were the armpit, palm, and sole. The assessment of treatment efficacy was performed by the questionnaires of the Dermatology Patient Quality of Life Index (DLQI) and Hyperhidrosis Severity Score (HDSS). Mean value of DLQI-score before treatment in group 1 was 18.1±4.3, and in in group 2 - 13.3±5.6 (the difference was significant - p<0.001). After treatment these scores were 8.3±5.5 and 6.6±5.3, respectively (the difference was not significant - p=0.228). As for intragroup difference of DLQI-scores before and after treatment, they were decreased significantly (p<0.001 for both groups). Moreover, the percentages of the patients with high degree HH were significantly decreased in both groups. However, the difference between the DLQI-scores of groups both before and after treatment was not significant. Both methods proved to be significantly effective for all three locations, especially for the armpit. However, no significant differences were observed when comparing the methods. The results of the study based on the DLQI-questionnaire indicate that application of both methods improved QoL of HH patients and decreased the degree of severity significantly. Both methods may be applied in the tactics of HH treatment with equal success rates. Additional randomized trials are needed to make evidence-based conclusions.

[The effect of the Karst cave climate on myocardium in experimental pneumonia]. / Vliianie klimata Karstovoi peschery na miokard pri ékperimental'noi pnevmonii.

Chronic pneumonia was modelled on rabbits after Zakharyevskaya-Anichkov method in authors own modification. The treatment was performed in the karst cave. Unlike to control animals normalization of present alterations in left ventricle myocardium was observed in experimental rabbits, regimen and duration of stay in the cave being of great importance, e. g. animals kept in the cave uninterruptedly for 22 d displayed almost complete normalization of both myocardium with its vessels and a series of immunological and biochemical parameters.

[Vessels of the heart and lung in some experimental defects]. / Sosudy serdtsa i legkogo pri nekotorykh éksperimental'nykh porokakh

Under study were changes of intraorganic blood vessels of the heart and lungs in some experimental defects (open arterial defect, coarctation of the aorta, simultaneous existence of these two defects, stenosis of the pulmonary trunk, defect of the interatrial septum, triad of Fallot, syndrom of Lutembachet). Morphological data correlated with blood pressure in the pulmonary circulation and cardiac chambers. The complex of compensatory-adaptational mechanisms consisting of comparatively active and passive zones is formed in the heart and lungs. In most cases the changes develop in the vessels already existing. In hypertrophy of the myocardium when there is hypertension and hypervolemia in coronary vessels, sinusoids perform the function of blood reservoir, to a certain degree balancing the blood pressure, and luminar ducts relieve the muscle from excessive blood. The changes in the vascular system of the lung are directly dependent upon the pressure in the pulmonary circulation and the duration of observation. The closing arteries are the most active link in the chain of compensatory-adaptational mechanisms.