[Incidence of antibodies against hepatitis virus A (anti-HA) in a non-selected urban population]. / Frecventa anticorpilor fata de virusul hepatitei A (anti-HA) într-o populatie urbana neselectata.

Anti-HA antibodies were determined by radioimmunoassay according to the HAVAB-ABBOTT technique in 244 subjects, of whom 194 without hepatic involvement, 25 with non B hva and 25 former non B hva patients. Anti-HA anti-bodies were found in 67% of the healthy subjects and 100% of the patients and former hva cases. The incidence of anti-HA antibodies increases with age being in 30% of children and 83.5% of adults. A peak incidence was found between the ages 21 and 30 years. In the district investigated subclinical infection with HVA was frequent, beginning in childhood and up to the age of 30 years. The qualitative HAVAB test is adequate for epidemiological investigations; a quantitative variant is necessary for the diagnosis.

[Protein changes in the jejunal juice and endointestinal exudation of albumin-I 131 in acute infectious enterocolitis]. / Modificarile proteinelor din sucul jejunal si exsadatia endointestinala de albumina 131I în enterocolitele acute infectioase

The phenomenon of endointestinal protein exudation in acute infectious enterocolitis is studied. Total proteins were determined in 30 cases of acute enterocolitis and 50 of bacillary dysentery in the acute stages of the disease and convalescence. The proteinogram of the jejunal juice was performed in the acute stage and convalescence in 20 patients. In 16 patients and 5 controls endointestinal albumin elimination was determined quantitatively by means of 131I labeled albumin. The results showed increase in the total protein content in the jejunal juice in the course of acute infectious enterocolitis and bacillary dysentery and a return to normal values in convalescence. Electrophoresis of the jejunal juice in acute infectious enterocolitis showed the absence of fraction III with alpha1-globulin migration, and increased fractions I, II and IV probably due to the loss of endointestinal albumin, also confirmed by quantitative albumin determinations with 131I labeled albumin. In conclusion, patients with acute infectious enterocolitis present a marked loss of endointestinal albumins in the acute stage of the disease, with a return to normal values in convalescence.

[Clinical and therapeutic observations on 34 cases of meningococcic meningitis]. / Observatii clinice si terapeutice pe marginea a 34 de cazuri de meningita meningococica

The present paper reports on 34 cases of meningococcal meningitis admitted during the last three years to the Clinic of Communicable Diseases of Cluj. The incidence was higher in adolescents and young adults (76%). The clinical form was severe in 10 cases, medium in 19 cases and mild in 5 cases. All the patients recovered, with a mean duration of the disease of 9-12 days. No sequelae or relapses were recorded. The treatment was based upon penicillin G, 15 million U/day. In 17 cases sulfonamides were associated and in 5 cases chloramphenicol and ampicillin. In 29 cases intravenous, intramuscular or oral cortisone was administered and in 5 cases intrathecally. The results obtained in the cases treated only with penicillin were identical to those obtained by an associated therapy. Worthy of note was the decrease of the sensitivity of meningococci to sulfonamides and chloramphenicol and their increased resistance to tetracyclin and erythromycin.