RESUMO
This study shows the results obtained with lovastatin as a combined therapy with probucol and cholestyramine on the lipid profile of two patients with homozygous familial hypercholesterolemia. Both have been diagnosed according to the clinical and biochemical criteria (tipe IIa hypercholesterolemia) as well as by the cholesterol or low density lipoprotein (LDL-C) receptor analysis. After the initial probucol and cholestyramine treatment we observed a drop of total cholesterol (T-C) of 41.7% and 46% as well as LDL-C of 51.6% and 49.3% in both patients. Respectively when lovastatin were associated an additional drop of T-C of 23.7%, LDL-C of 23.2%, high-density lipoprotein cholesterol (HDL-C) of 22.4% and the apoprotein B (Apo B) of 37% were obtained in one patient (receptor-defective) but no change in the lipid profile were obtained in the other patient (receptor-negative). No adverse effects were observed with this drug. This drug could be of help as a combined therapy in the treatment of homozygous familial hypercholesterolemia, even though the treatment of choice is the LDL-plasma feresis and/or liver transplantation. We expound the difficulties relate to LDL receptor study in homocygous receptor-negative patients.
Assuntos
Hiperlipoproteinemia Tipo II/tratamento farmacológico , Lovastatina/uso terapêutico , Receptores de LDL/efeitos dos fármacos , Resina de Colestiramina/uso terapêutico , Quimioterapia Combinada , Homozigoto , Humanos , Hiperlipoproteinemia Tipo II/genéticaAssuntos
Adenoma de Células das Ilhotas Pancreáticas/tratamento farmacológico , Antineoplásicos/uso terapêutico , Insulinoma/tratamento farmacológico , Neoplasias Pancreáticas/tratamento farmacológico , Somatostatina/análogos & derivados , Feminino , Humanos , Pessoa de Meia-Idade , Octreotida , Somatostatina/uso terapêuticoAssuntos
Acromegalia/etiologia , Tumor Carcinoide/metabolismo , Hormônio Liberador de Hormônio do Crescimento/metabolismo , Neoplasias Pulmonares/metabolismo , Acromegalia/metabolismo , Acromegalia/cirurgia , Tumor Carcinoide/complicações , Tumor Carcinoide/cirurgia , Feminino , Hormônio Liberador de Hormônio do Crescimento/análise , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/cirurgia , Microscopia Eletrônica , Pessoa de Meia-IdadeAssuntos
Córtex Suprarrenal/fisiopatologia , Dexametasona , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Injeções Intramusculares , Masculino , Pessoa de Meia-IdadeRESUMO
A group of 163 patients with cold thyroid nodules was studied. Of these, 131 underwent surgery with thyroid neoplasms being found in 33 cases (22.13%). No statistically significant differences were seen in frequency of neoplastic cold thyroid nodules between males and females; in time of evolution between neoplastic and non-neoplastic cold thyroid nodules; or in mean age of the groups with neoplastic and non-neoplastic cold nodules. On the other hand, there were significant differences between the mean age of patients with different types of thyroid neoplasms. In conclusion, as at present no diagnostic technique allowing a clear differentiation between neoplastic and non-neoplastic cold thyroid nodules is available for preoperative use, surgical intervention is desirable in cases of this type.