[The anti-arrhythmic efficacy of sodium valproate]. / Antiaritmicheskaia éffektivnost' natriia val'proata.

The antiarrhythmic efficacy of the anticonvulsant sodium valproate was studied in 22 patients with ventricular premature contraction in the immediate (10-15 days) and late (2-5 months) periods of therapy. The prolong antiarrhythmic effect of the drug was observed in 66% of the patients in whom it was beneficial in the first days of therapy. The results obtained provide strong evidence for the efficacy of sodium valproate in patients with ventricular premature contraction occurring in the presence of neurocirculatory dystonia.

[Evaluation of the possibility of selection of individual anti-arrhythmia therapy]. / Otsenka vozmozhnosti individual'nogo podbora antiaritmicheskoi terapii.

Antiarrhythmic therapy was chosen for 3-7 days by modified chronic electrophysiological study at three stages: (1) the efficacy of a drug, its action onset and termination were defined; (2) a dosage was chosen on an individual basis and the duration of drug potency was specified; (3) the dosage regimen of a drug given as a course therapy was confirmed by the results of trials. Its choice was made on the basis of the oral administration of a tested drug and multiple programmed electric cardiostimulation. In late periods (3-37 months), the therapy was effective and safe in 51 (86%) of 59 patients. The drug regimens and doses were in poor agreement with conventional ones in 49% of the patients. The method proposed makes it possible to choose antiarrhythmic therapy on an individual basis and reduce the number of complications.

[Effectiveness of the methods of electric cardiac stimulation and low-energy cardioversion-defibrillation in the prevention and treatment of ventricular tachycardia and ventricular fibrillation]. / Effektivnost' metodov élektrokardiostimuliatsii, nizko- énergeticheskoi kardioversii-defibrilliatsii v preduprezhdenii i lechenii zheludochkovykh takhikardii i fibrilliatsii zheludochkov.

The efficiency of treatment of ventricular tachycardias and fibrillation in cardiologic and cardiac surgical practice was examined in 154 patients by employing new unique means and facilities for automatic cardioversion-defibrillation of the heart. A comparative analysis was made of the efficiency of prevention of ventricular fibrillation and arrest of ventricular tachycardias by using various electric cardiac stimulation. The investigations indicated ventricular arrhythmia deaths might be significantly reduced by applying various methods of electric pulse therapy. The differential use of ++anti-tachycardia cardiac pacing and automatic low-energy cardioversion-defibrillation decreases the number of complications and enhances the efficiency of therapy in this contingent of patients.

[Reproducibility of reciprocal atrioventricular tachycardia during intracardiac and transesophageal electric stimulation]. / Vosproizvodimost' retsiproknykh atrioventrikuliarynkh takhikardii pri vnutriserdechnoi i chrespishchevodnoi elektro-kardiostimuliatsii.

A feasibility to provoke reciprocal atrioventricular tachycardias was examined in 23 patients with atrioventricular nodal tachycardia and 17 with orthodromal tachycardia in the presence of the Wolff-Parkinson-White syndrome with endocardiac and transesophageal diagnostic pacing. Atrioventricular nodal tachycardia could be induced in all 23 (100%) patients both by endocardiac and transesophageal pacing. Orthodromal tachycardia was provoked only in 9 (53%) of 17 patients by transesophageal pacing. It was generally noted that tachycardia induction required more "aggressive" regimens of transesophageal pacing than endocardiac one. Endocardiac diagnostic pacing is now a more informative technique, but transesophageal pacing requires further development.

[First experiences with the effect of low-energy electric impulse on the atrioventricular junction in various types of paroxysmal supraventricular tachycardia]. / Pervyi opyt nizkoénergeticheskogo élektroimpu'lsnogo vozdeistviia na atrioventrikuliarnoe soedinenie serdtsa pri nekotorykh paroksizma'lnykh nadzheludochkovykh takhikardiiakh.

Efficient treatment of paroxysmal supraventricular reciprocal tachycardias (nodal and orthodromal) was studied in 29 patients by applying low-energy discharges (mean 2.3 +/- 0.1 kV) to the area of the atrioventricular junction. Late results of the treatment were assessed 7-22 months later. Cessation of tachycardia paroxysms was observed in 10 patients, their lower frequency (by more than 50%) was seen in 14 cases. The value of discharge energy, their numbers, relations between potential amplitudes produced by atria and His' bundle, feasibility of paroxysm induction, presence or absence of bundle-branch block were not prognostic criteria for efficiency of this mode of therapy in the present investigation. In the authors' opinion, the method is promising in the treatment of atrioventricular nodal and orthodromal paroxysmal tachycardias.

[A combination of kordaron with ritmilen: its effect on the electrophysiology of the heart and its clinical effectiveness]. / Kombinatsiia kordarona s ritmilinom: vliianie na élektrofiziologiiu serdtsa i klinicheskaia Teffektivnost'.

Combined effect of cordarone and ritmilen on myocardial electrophysiology was assessed in an acute medicated test, on the basis of electrophysiologic studies and transesophageal pacing test, in patients with resistant paroxysmal supraventricular tachycardia. The cordarone-ritmilen combination has proved efficient in 82.4% of cases and caused a significant change of the P-Q interval and effective refractory period (ERPav, ERPrv, ERPiv). The Q-T interval increased but never resulted in ventricular arrhythmias. Good antiarrhythmic effect was seen in 70.4% after 12 months. There were side effects in 10.7% of cases.