[Malignant lymphoma with "hairy" lymphocytes in the blood and splenomegaly--a new variant of lymphoproliferative diseases]. / Zlokachestvennaia limfoma s "volosatymi" limfotsitami v krovi i splenomegaliei--novyi variant limfoproliferativnogo zabolevaniia..

A total of 5 patients with a clinicohematological picture resembling hairy-cell leukemia (HCL) have been described. However, the morphological features of leukemic lymphocytes, the absence of acid phosphatase in them, the nodular character of the bone marrow lesion combined with an unusual phenotype have permitted the authors to distinguish these cases as a separate variant of B-cell malignant lymphoma. Paraprotein (M-class) was detected in the blood of two of the patients. A conclusion has been made that the combination of splenomegaly with hairy lymphocytes in the blood is characteristic of not only HCL, but it can be also observed in different variants of malignant lymphoma.

Hairy cell leukemia and other "hairy-cell" lymphoproliferative disorders (LPD-HC): the significance of morphologic, histologic and immunologic studies.

In this report the clinical, morphologic, histologic and immunologic findings of 41 patients with hairy lymphoid cells in peripheral blood and/or bone marrow are analyzed. In 27 patients the diagnosis of hairy cell leukemia was established. 14 patients had other variants of lymphoproliferative disorders: malignant lymphoma with hairy cells--7, chronic lymphocytic leukemia with hairy cells--5, and T cell lymphoproliferative disorder with hairy cells--2 patients, respectively. Several variants of malignant lymphoma with hairy cells were defined: lymphocytic, centrocytic and lymphoplasmacytic. The importance of combined use of bone marrow biopsy and immunophenotyping for the correct diagnosis of hairy cell leukemia and other "hairy-cell" lymphoproliferative disorders is stressed. The obtained data suggest relationship between characteristic clinical manifestation (isolated splenomegaly), presence of hairy cells and CD11c-antigen expression.

[2 phenotypic variants of B-cell lymphocytic leukemia]. / Dva fenotipicheskikh varianta B-kletochnogo khronicheskogo limfoleikoza.

A phenotype of lymphoid cells of peripheral blood in 38 patients with B-cel chronic lymphocytic leukaemia (B-CLL) was determined by means of a set of monoclonal antibodies. In the majority of the cases (32 persons--group I) the cells had an incomplete phenotype (CD 20+, CD 21-, CD 22-, CD 24+, CD 37+). In 6 patients (group II) cells had all the surface markers peculiar to B-CLL cells (phenotype--CD 20+, CD 21+, CD 22+, CD 24+, CD 37+). In 2 out of 6 cases lymphoid cells contained E-receptor (CD 2+). Cells of the patients from group I and II differed also in the level of TUI-receptor. An assumption is advanced about the existence of two phenotypic variants of B-CLL and about a possible association of CD 21 and CD 22 receptors.

[Imbalance of T lymphocyte subpopulations in patients with psoriasis and its immune correction]. / Dysbalance der T-Lymphozyten-Subpopulationen bei Psoriasis-Patienten und ihre Immun-Korrektion.

We investigated the levels of T-lymphocytes and their subpopulations-T-helper cells (TH) and T-suppressor cells (TS)-in the peripheral blood of 57 patients suffering from various clinical forms of psoriasis. Considerable decrease of the TH/TS rate (0.2 to 1.2) was found in 29 patients (15 with vulgar, 8 with arthropatic, and 6 with exudative psoriasis). The total number of T-lymphocytes was normal in 20 of these patients. In 8 patients showing a marked disbalance of TH and TS immunomodulators, thymalin and natrii nucleinas were included in the complex schedule of antipsoriatic therapy. As a result of the immunocorrective therapy, the disbalance normalized in 6 cases accompanied by regression of the psoriatic rash. The disbalance of TH and TS in the peripheral blood of the patients has a certain pathogenic significance in the development of psoriasis, and immunocorrection becomes necessary for successful therapy in severer forms of the disease.

[T-lymphocyte subpopulations in the blood of patients with chronic B-cell lympholeukemia studied using monoclonal antibodies]. / Issledovanie subpopuliatsii T-limfotsitov v krovi bol'nykh B-kletochnym khronicheskim limfoleikozom s pomoshch'iu monoklonal'nykh antitel.

The contents of T-lymphocytes and their basic subpopulations (T-helpers and T-suppressors) in peripheral blood of 40 patients with B-cellular chronic lymphatic leukemia was studied (CLL) using monoclonal antibodies. It is shown that an imbalance of T-helpers and T-suppressors is observed in many patients (a ratio of helpers/suppressors less than 1.29 in 24 patients) at the expense of a decrease in the relative content of T-helpers in patients at stage I-III of CLL and an increase in the contents of T-suppressors in patients at stage IV. A correlation is revealed between the ratio of T-helpers and T-suppressors, on the one hand, and the stage of the disease, on the other hand.

[Chronic T-cell lymphoid leukemia with helper cell phenotype]. / T-kletochnyi khronicheskii limfoleikoz s khelpernym fenotipom kletok.

Tumour cells of a patient with T-cell chronic lymphocytic leukemia had surface (E+, OKT3+, OKT4+, OKT8-, SIg-, Ia-) and cytochemical (properties positive reaction to acid phosphatase, acid nonspecific esterase and negative reaction to terminal deoxynucleotidyl transferase) specific for T-helper lymphocytes. They had no activity of NK and K-cells, reacted weakly to mitogens (PHA, Con A, PWM) and allogenic cells. Con A and PWM stimulated synthesis of specific receptors (OKT3 and OKT4) on the surface of malignant cells, whereas PHA decreased the amount of above receptors.