Clinical features related to CSF level of amyloid Aß42 and Aß40 proteins in presence of lobar microbleeds.

In presence of lobar microbleeds, the exact clinical features related to the level of Aß42, Aß40 and to the Aß40/Aß42 ratio in the cerebrospinal fluid (CSF) are poorly known. We analyzed in 28 consecutive patients with such lesions, whose clinical or additional magnetic resonance imaging features are related to these biomarkers. The results showed that the presence of absence of hypertension, the extent or the antero-posterior distribution of white matter hyperintensities, the presence or absence of vascular lesions in the deepest parts of the brain, and the presence of dementia are related to variations of Aß42, Aß40 or of the Aß40/Aß42 ratio in the cerebrospinal fluid.