Personal factors associated with the attitudes of nurses towards patients with obesity: a literature review.

This literature review explores the association between body mass index and self-esteem in nurses, alongside their attitudes towards patients who have obesity. These variables have either previously been linked to weight bias, or with prejudice more generally, but findings in this context are inconclusive. Searches were conducted through Psychology Cross Search, PubMed, Web of Science, Proquest Allied Health Professionals and Google Scholar. Ten studies met the inclusion criteria and were tabulated and critiqued using appropriate appraisal tools. The literature covered a time span of over 30 years with the type and quality of study methodologies varying. Research was rarely underpinned by theory. As such, no consensus was reached in drawing together the findings but the direction of future research needed to address these issues is discussed. Further research should focus on developing the literature using an appropriate theoretical underpinning in order to better understand the research that has begun further afield.

All bereaved parents are entitled to good care after stillbirth: a mixed-methods multicentre study (INSIGHT).

OBJECTIVE: To understand challenges in care after stillbirth and provide tailored solutions. DESIGN: Multi-centre case study. SETTING: Three maternity hospitals. POPULATION: Parents with a stillborn baby, maternity staff. METHODS: Thematic analysis of parent interviews and staff focus groups and service provision investigation. OUTCOMES: 1 Themes; 2 Triangulation matrix; 3 Recommendations. RESULTS: Twenty-one women, 14 partners, and 22 staff participated. Service Provision: Care for parents after stillbirth varies excessively; there are misconceptions; post-mortem does not delay follow-up. PRESENTATION: Women 'do not feel right' before stillbirth; their management is haphazard and should be standardised. DIAGNOSIS: Stillbirth is an emergency for parents but not always for staff; communication can seem cold; well-designed bereavement space is critical. Birth: Staff shift priorities to mother and future, but for parents their baby is still a baby; parents are not comfortable with staff recommending vaginal birth as the norm; there are several reasons why parents ask for a caesarean; better care involves clear communication, normal behaviour, and discussion of coping strategies. Post-mortem: Parents are influenced by discussions with staff. Staff should 'sow seeds', clarify its respectful nature, delineate its purpose, and explain the timescale. FOLLOW-UP: It is not standardised; parents wish to see their multi-professional team. CONCLUSIONS: There is unacceptable variation in care after stillbirth, and insensitive interactions between staff and bereaved parents. Understanding parents' needs, including why they ask for caesarean birth, will facilitate joint decision-making. Every bereaved parent is entitled to good, respectful care. TWEETABLE ABSTRACT: Care too varied & interactions often insensitive after stillbirth; national pathway & training urgently needed PLAIN LANGUAGE SUMMARY: Why and how was the study carried out? Previous studies have shown that improving care after stillbirth is important for families. We investigated the opinions of bereaved parents and maternity staff to find ways to improve care. At three hospitals in 2013, all women who experienced a stillbirth were invited to an interview along with their partners. Thirty-five parents of 21 babies agreed to participate. Twenty-two obstetricians and midwives took part in focus group discussions. What were the main findings? Care was often not as good as it should and could be. Communication with parents was not always as sensitive as they would have liked because staff did not have appropriate training. Some women reported they did not 'feel right' before going to hospital. Once they arrived, there was no standard approach to how care was given. Sometimes there were long delays before the death of the baby was confirmed and action was taken. After it had been confirmed that the baby had died, staff focussed on the mothers' needs, but the parents' priorities were still with their baby. There were several reasons why parents asked for a caesarean birth that staff had not considered. Staff influenced parents' decisions about post-mortem examinations. Parents found it helpful when staff explained the respectful nature and purpose of the examination. After discharge from hospital, there was no consistent plan for how follow-up care would be given. Parents would have liked more information about their next hospital appointment. What are the limitations of the work? The parents interviewed depended on their memories of the details of the care, which happened some time ago. In staff group discussions, junior doctors may not have spoken openly because there were senior doctors present. Further research is necessary to understand and improve care globally. What is the implication for parents? Every bereaved parent is entitled to the best possible care after stillbirth, but some do not get good care. Parents and staff made suggestions that can help to develop processes for how care is given after stillbirth. These suggestions can also inform staff training, so that every single parent is treated respectfully and participates in decision making.

Mixed methods in health psychology: theoretical and practical considerations of the third paradigm.

This article has two purposes: to examine why mixed methods is a legitimate approach particularly well suited to health psychology; and to describe the challenges inherent in conducting mixed methods research. First, arguments justifying the status of mixed methods as a third paradigm alongside solely quantitative and qualitative frameworks are discussed. Second, a qualitatively driven model of mixed methods is illustrated using examples from a research programme exploring the psychosocial impact of a rare, genetic skin disorder. The flexibility of a mixed methods approach enables the researcher to be responsive to a range of issues, but it is important the approach is used thoughtfully and appropriately.

'You're whatever the patient needs at the time': the impact on health and social care professionals of supporting people with epidermolysis bullosa.

OBJECTIVES: Professionals working with people who encounter pain and suffering can experience adverse emotional effects themselves. However, to provide effective support it is necessary to understand specific work-related experiences and contexts. This study investigated the impact on professionals of supporting people with the skin condition 'epidermolysis bullosa'. METHODS: A two-part mixed methods design was utilized. Part one comprised interviews with specialist nursing and social care professionals (n = 7). Part two comprised a survey administered to a range of EB specialist professionals (n = 26). RESULTS: The interview data were analysed inductively and informed the survey design. The survey data were analysed deductively and compared to the interview findings. Three integrated themes were subsequently depicted: the intensity and depth of involvement; managing with limited resources; and the need to look after yourself. DISCUSSION: Findings show the ways in which the work can affect well-being and how the impact is intensified by the low numbers of specialist professionals in the field. But the support of team members, access to effective supervision and the rewards of working with a remarkable population make the professional role worthwhile. Adequate clinical supervision, skills training and access to multi-disciplinary expertise were all highlighted as beneficial for well-being.

Transbronchial biopsy with virtual CT bronchoscopy and nodal highlighting.

Transbronchial biopsy to sample lymph nodes and tumors that are not visible at endoscopy has a poor (<50%) success rate. These nodes can be highlighted easily at virtual computed tomographic (CT) bronchoscopy to provide a guide. This study was performed to evaluate if the addition of this information to the bronchoscopist improved the success rate of transbronchial biopsy of subcarinal and aortopulmonary lymph nodes. The addition of virtual CT bronchoscopy with lymph node highlighting significantly (P < .5) increased biopsy success rates for pretracheal, hilar, and high pretracheal adenopathy.

Contribution of perfusion pressure to vascular resistance response during head-up tilt.

We measured brachial and femoral artery flow velocity in eight subjects and peroneal and median muscle sympathetic nerve activity (MSNA) in five subjects during tilt testing to 40 degrees. Tilt caused similar increases in MSNA in the peroneal and median nerves. Tilt caused a fall in femoral artery flow velocity, whereas no changes in flow velocity were seen in the brachial artery. Moreover, with tilt, the increase in the vascular resistance employed (blood pressure/flow velocity) was greater and more sustained in the leg than in the arm. The ratio of the percent increase in vascular resistance in leg to arm was 2.5:1. We suggest that the greater vascular resistance effects in the leg were due to an interaction between sympathetic nerve activity and the myogenic response.

The control of breathing in clinical practice.

The control of breathing results from a complex interaction involving the respiratory centers, which feed signals to a central control mechanism that, in turn, provides output to the effector muscles. In this review, we describe the individual elements of this system, and what is known about their function in man. We outline clinically relevant aspects of the integration of human ventilatory control system, and describe altered function in response to special circumstances, disorders, and medications. We emphasize the clinical relevance of this topic by employing case presentations of active patients from our practice.

Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study.

BACKGROUND: Many volatile organic compounds (VOCs), principally alkanes and benzene derivatives, have been identified in breath from patients with lung cancer. We investigated whether a combination of VOCs could identify such patients. METHODS: We collected breath samples from 108 patients with an abnormal chest radiograph who were scheduled for bronchoscopy. The samples were collected with a portable apparatus, then assayed by gas chromatography and mass spectroscopy. The alveolar gradient of each breath VOC, the difference between the amount in breath and in air, was calculated. Forward stepwise discriminant analysis was used to identify VOCs that discriminated between patients with and without lung cancer. FINDINGS: Lung cancer was confirmed histologically in 60 patients. A combination of 22 breath VOCs, predominantly alkanes, alkane derivatives, and benzene derivatives, discriminated between patients with and without lung cancer, regardless of stage (all p<0.0003). For stage 1 lung cancer, the 22 VOCs had 100% sensitivity and 81.3% specificity. Cross-validation of the combination correctly predicted the diagnosis in 71.7% patients with lung cancer and 66.7% of those without lung cancer. INTERPRETATION: In patients with an abnormal chest radiograph, a combination of 22 VOCs in breath samples distinguished between patients with and without lung cancer. Prospective studies are needed to confirm the usefulness of breath VOCs for detecting lung cancer in the general population.

A survey to identify potential outcome indicators for a hospital blood glucose monitoring program.

OBJECTIVE: A survey of operators of a bedside blood glucose monitoring (BGM) program at a tertiary health care institution was performed to identify potential outcome indicators for our quality assurance program. DESIGN AND METHODS: 170 surveys were randomly distributed to each nursing unit. The survey consisted of 20 questions on 4 pages. At the time of the survey, the BGM program consisted of 514 operators and 33 blood glucose meters on 17 inpatient nursing units servicing a total of 445 hospital beds. RESULTS: Seventy-eight percent of surveys were returned. Seventy-one percent of operators used the glucose meter at least once a week, 17% used it less than once a week, and 12% used it less than once a month. When asked how often they thought operators should perform BGM to ensure reliability, 65% stated "at least monthly," 8% said "bimonthly," and 27% said "3 to 4 times a year." In the previous 3 months, 59% of operators recalled "never having to repeat a BGM measurement with the glucose meter." 56% recalled "never having to confirm a BGM result by sending a venous sample to the central laboratory," 38% recalled "sending a venous sample once or twice;" 4% recalled "three or four times;" and 2% recalled "more than four times." Fifty-two percent recalled having to perform a stat analysis "less than once per month," 37% recalled "once or twice per month," and 11% recalled "once or twice per week." CONCLUSIONS: Through this survey we obtained information from our operators about the current functioning of our BGM program. Based on this information, we were able to develop a list of potential outcome indicators that we encourage health care institutions with BGM programs to consider incorporating in their quality assurance (QA) program.

Respiratory arousal from sleep: mechanisms and significance.

The mechanisms by which respiratory stimuli induce arousal from sleep and the clinical significance of these arousals have been explored by numerous studies in the last two decades. Evidence to date suggests that the arousal stimulus in nonrapid eye movement sleep (NREM) is related to the level of inspiratory effort rather than the individual stimuli that contribute to ventilatory drive. A component of the arousal stimulus proportional to the level of inspiratory effort may originate in mechanoreceptors either in the upper airway or respiratory pump. Medullary centers responsible for ventilatory drive may also send a signal proportionate to the level of drive to higher centers in the brain which are responsible for arousal. Thus, the arousal stimulus may consist of multiple components, each increasing as inspiratory effort increases. The level of effort triggering arousal is an index of the arousability of the brain (arousal threshold). A deeper stage of sleep, central nervous system depressants, prior sleep fragmentation, and the presence of obstructive sleep apnea (OSA) have been observed to increase the arousal threshold to airway occlusion. Less information is available concerning the mechanisms of arousal from rapid eye movement (REM) sleep. While REM sleep is associated with the longest obstructive apneas in patients with OSA, normal human subjects appear to have a similar or lower arousal threshold to respiratory stimuli in REM compared to NREM sleep. Recent studies have challenged the assumption that the termination of all obstructive apnea is dependent on arousal from sleep. Improvements in methods to detect and quantitate changes in the cortical electroencephalogram (EEG) may better define the relationship between arousal and apnea termination. This may result in improved criteria for identifying EEG changes of clinical significance. While little is known concerning the mechanisms of arousal in central sleep apnea, arousal may play an important role in inducing this type of apnea in some patients.

Quantitative aspiration during sleep in normal subjects.

STUDY OBJECTIVE: To determine the within-subject variability and to estimate the quantity of occult aspiration of nasopharyngeal secretions during sleep in normal humans. DESIGN: Prospective duplicate full-night sleep studies. SETTING: Pulmonary sleep laboratory, university hospital. PARTICIPANTS: Ten normal male volunteers aged 22 to 55 years. INTERVENTIONS: Two full-night polysomnographic recordings with infusion of 2 mL/h radioactive 99mTc tracer into the nasopharynx through a small catheter during EEG-documented sleep. Standard lung scans were conducted immediately following final awakening. Aspiration was defined as the presence of radioactivity in the pulmonary parenchyma on two separate views. RESULTS: A mean sleep efficiency of 85.7 +/- 2.6% was found with no difference between the two study nights. A total of 5 of the 10 subjects studied had tracer evident in the pulmonary parenchyma following final awakening. Three had the tracer apparent following the first-night study and four had tracer apparent following the second-night study. Thus, two subjects aspirated on both nights. Comparing the subjects who aspirated with those who did not, no significant difference could be found for age, time spent in bed, sleep efficiency, apnea-hypopnea index, arousal plus awakening index, or percent of sleep time spent in a supine position. The quantities of tracer aspirated were on the order of magnitude of 0.01 to 0.2 mL. CONCLUSIONS: Aspiration measured by this technique occurs commonly in healthy young men during sleep, is unrelated to sleep quality, and is variable within subjects studied on more than one occasion. The quantity aspirated is of an order of magnitude likely to contain bacterial organisms in physiologically significant quantities.

Diagnostic flexible fiberoptic pleuroscopy in suspected malignant pleural effusions.

Up to 25% of malignant pleural effusions can remain undiagnosed following history, physical examination, thoracentesis, and percutaneous closed pleural biopsy. The next diagnostic procedure is often rigid thoracoscopy, an invasive procedure requiring an operating suite and usually a postprocedure chest tube. We performed flexible fiberoptic pleuroscopy using a fiberoptic bronchoscope in conjunction with a closed pleural biopsy on 12 patients with exudative pleural effusions that remained undiagnosed despite extensive clinical evaluation. A sterile 4.8-mm outside diameter flexible fiberoptic bronchoscope was placed into the pleural space during the course of a routine closed pleural biopsy. Pneumothorax was induced to allow visualization. Brush or forceps biopsy specimens of suspicious parietal pleural lesions were taken. Eight pleural spaces appeared smooth while four were diffusely studded on the parietal surface. Of these four, three were proven to have diffuse pleural adenocarcinoma using this procedure; the fourth proved ultimately to have pleural mesothelioma. On long-term follow-up (mean = 17.7 +/- 11.4 months), no false-negative studies or unexpected morbidity was noted. Flexible fiberoptic pleuroscopy may provide a diagnosis in exudative pleural effusions when other less invasive procedures fail to do so and is well tolerated with minimal discomfort and risk.

Effect of low-dose prednisolone on sperm fertilizing capacity in subfertile men with circulating antisperm antibodies.

To assess if low-dose prednisolone reduced circulating antisperm antibodies and improved sperm fertilizing capacity, the hamster oocyte penetration test (HOPT) was used to evaluate treatment in 36 males with significant serum antisperm antibodies, measured by the tray agglutination test (TAT). Prednisolone 5 mg three times a day for 3 months was used. Only couples in whom all tests in the female partner were normal were entered into the study. A significant increase in sperm density, normal morphology, and HOPT were noted after therapy (p < .001). A significant decrease in antisperm antibody titer was noted (p < .0001) and correlated with improvement of HOPT (p < .05). There were no significant side effects. Six pregnancies (17%) occurred. Three pregnancies (18%) occurred in partners of an untreated group of 17 men. Prednisolone therapy in this regime does not significantly improve pregnancy rates. The HOPT does not offer any additional information for predicting patients who will show an improvement in antibody titers or achieve pregnancy after steroids.

Life-threatening pneumonia.

Severe pneumonia can be acquired by previously healthy patients, those with pre-existing illness, or those hospitalized for an unrelated illness. Because diagnosis is frequently difficult or delayed, treatment is usually empirically tailored to the most probable offending organisms and the patient's condition. This article reviews the pathogenesis of community- and hospital-acquired pneumonia, clinical features, and diagnostic techniques. An approach to selecting an antibiotic regimen is suggested.

Exercise induced asthma: a clinical perspective.

Exercise is a very common precipitant of asthma. Inflammation and edema are felt to be important components of the asthmatic response. Heat and water loss from the airway mucosa are most likely important in its pathogenesis, although the exact etiology remains unknown. A good history combined with proper diagnostic testing can usually determine the diagnosis, and prevention is the key to effective management. Although modified training techniques are often helpful, medications are usually needed for both prevention and treatment. While antiinflammatory agents are gaining therapeutic importance, inhaled beta-agonists remain the treatment of choice. With appropriate diagnosis and management, exercise-induced asthma should not limit participation nor performance in athletics for the great majority of the population.

Ventilatory pattern after hypoxic stimulation during wakefulness and NREM sleep.

The ventilatory after-discharge mechanism (VAD) may stabilize ventilation (VE) after hyperventilation but has not been studied in detail in humans. Several studies conducted during wakefulness suggest that VAD is present, although none has been conducted during sleep, when disordered ventilation is most common. We conducted two experiments during wakefulness and non-rapid-eye-movement (NREM) sleep in 14 healthy young men to characterize the ventilatory response after termination of a 45- to 60-s 10-12% O2 hypoxic stimulus. Eight subjects had triplicate hypoxic trials terminated by 100% O2 during wakefulness and NREM sleep. Hypoxia caused a drop in arterial O2 saturation to 78.5 +/- 0.5%, an increase in VE of 4.4 +/- 0.6 l/min, and a decrease in end-tidal PCO2 of 4.4 +/- 0.4 Torr during wakefulness, with no significant differences during sleep. When the hypoxia was terminated with 100% O2, VE was variable within and between subjects during wakefulness. During sleep, all subjects developed hypopnea (VE < 67% baseline) with a mean decrease of 65.5 +/- 7.8% at the onset of hyperoxia (P < 0.05 compared with baseline VE). We hypothesized that this uniform decrease in VE might be due to the nonphysiological hyperoxia employed. We therefore studied six additional subjects, all during NREM sleep, with identical hypoxic stimulation of breathing terminated by 100% O2 or room air. We again found that termination of hypoxia with 100% O2 produced uniform hypoventilation. However, when the identical stimulus was terminated with room air, no hypoventilation occurred.(ABSTRACT TRUNCATED AT 250 WORDS)

Reproductive rights in jeopardy. The Supreme Court upholds restrictions on abortion.

PIP: The US Supreme Court decision in Planned Parenthood of Southeastern Pennsylvania v. Casey means restrictions to a woman's access to abortion. The justification is not medical. The implication is that access to contraception and family planning is also in jeopardy. Pennsylvania state regulations requiring state-sanctioned abortion counseling and a 24-hour waiting period, and parental consent or a judicial bypass for those 18 years were upheld. The decision affirms a woman's right to terminate a pregnancy, but did not affirm Roe v. Wade as a constitutional right. The new standard established an undue burden test,which by some is considered too vague. All medical procedures require consent and it is unclear what the new abortion counseling contributes. Doctors are required to recite a state-mandated lecture on the hazards of abortion in order to influence a woman's choice, which is an infringement on doctor/patient relations and an individual's right to choose. The information is designed to persuade the woman to in fact not give her consent. Another disincentive is the waiting period. It assumes also that there is time and money available and equal access for 24-hour waiting. Clinics are becoming the primary providers of abortion. 83% of counties did not have a physician capable of performing an abortion. 1 in 5 metropolitan areas does not have any abortion provider. 27% of abortion seekers had to travel 50-100 miles to reach providers. 85% of providers reported harassment or violence committed by anti-choice demonstrators. 25% of obstetrics and gynecology residency training programs do not offer abortion training, when abortion procedures are one of the most commonly performed procedures. Justices O'Connor, Souter, and Kennedy supported the decision, while Chief Justice Rehnquist and Justices Scalia, White, and Thomas dissented and desired an outright overturning of Roe v. Wade. A challenge of the undue burden clause is expected. The teenage restrictions contrast sharply with research and opinion.^ieng

Effect of oxygen breathing following submaximal and maximal exercise on recovery and performance.

To determine whether supplemental oxygen following exercise hastens recovery or enhances subsequent performance we evaluated its effectiveness in 13 male athletes. The exercise periods consisted of two 5-min submaximal efforts on a treadmill ergometer followed by a single bout to exhaustion. Intervals of exercise were separated by a 4-min recovery period during which the subject breathed either 1) room air, 2) 100% oxygen, or 3) 2 min of 100% oxygen followed by 2 min of room air on three nonconsecutive days. We found that breathing 100% oxygen produced no significant difference on the recovery kinetics of minute ventilation or heart rate, or improvement in subsequent performance as measured by duration of exercise (3.33 +/- 0.04 min, air vs 3.46 +/- 0.03, oxygen) and peak VO2 (59.9 +/- 2.2 ml.kg-1.min-1, air vs 54.5 +/- 2.2, oxygen). In addition, the perceived magnitude of exertion estimated by the Borg scale was no different during oxygen breathing. These findings offer no support for the use of supplemental oxygen in athletic events requiring short intervals of submaximal or maximal exertion.

Adenosine infusion and periodic breathing during sleep.

Intravenously administered adenosine may increase ventilation (VI) and the ventilatory response to CO2 (HCVR). Inasmuch as we have previously hypothesized that those with higher HCVR may be more prone to periodic breathing during sleep, we measured VI and HCVR and monitored ventilatory pattern in seven healthy subjects before and during an infusion of adenosine (80 micrograms.kg-1.min-1) during uninterrupted sleep. Adenosine increased the mean sleeping VI (7.6 +/- 0.4 vs. 6.5 +/- 0.4 l/min, P less than 0.05) and decreased mean end-tidal CO2 values (42.4 +/- 1.2 vs. 43.7 +/- 1.0 Torr, P = 0.06, paired t test) during stable breathing. In six of seven subjects, periodic breathing occurred during this infusion. The amplitude (maximum VI--mean VI) and period length of this periodic breathing was variable among subjects and not predicted by baseline HCVR [correlation coefficients (r) = 0.64, P = 0.17 and r = -0.1, P = 0.9, respectively]. Attempts to measure HCVR during adenosine infusion were unsuccessful because of frequent arousals and continued periodic breathing despite hyperoxic hypercapnia. We conclude that adenosine infusion increases VI and produces periodic breathing during sleep in most normal subjects studied.