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1.
J Orthop Case Rep ; 12(3): 81-84, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36199935

RESUMO

Introduction: Proximal humerus fractures are common injuries of the upper extremity. These fractures are frequent in the elderly population due to low-energy trauma and in the younger patient secondary to high-energy trauma that is associated with shoulder dislocations. Proximal humerus fractures are frequently classified according to the Neer classification which is defined by the number of segments and the amount displacement required to define the fracture as displaced. Segments include the greater tuberosity (GT), the lesser tuberosity, the humeral head, and the humeral shaft. Fractures are considered displaced if there is at least 45° of angulation or 1 cm of displacement. Case Report: We present a case of a 42-year-old Caucasian patient with a displaced and incarcerated GT avulsion fracture following a motorcycle accident. In this report, we describe the patient positioning, technique using open reduction internal fixation utilizing multiple anchors and suture to treat this injury and the successful outcome of our patient 1 year from the injury. Conclusion: While standard open reduction internal fixation techniques using plates and screws are appropriate for treating these injuries, we chose to pursue a method that involved only bio-absorbable suture anchors. Using these anchors, we were able to achieve an anatomic reduction of the GT fragment that ultimately went on to achieve full healing.

2.
Arthrosc Tech ; 10(1): e229-e234, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33532233

RESUMO

Unicompartmental knee arthroplasty (UKA) is becoming a more prevalent treatment for medial-compartment arthritis. Traditionally, a competent anterior cruciate ligament (ACL) is required to achieve satisfactory results. This leads to the question of treatment for medial-compartment arthritis in the setting of an incompetent ACL. A treatment option for this subset of patients is concurrent UKA and ACL reconstruction; however, this technique addresses the cohort of patients with a previously stable UKA who sustain an injury to the ACL, leading to symptomatic instability. The purpose of this article is to detail a technique for ACL reconstruction in the setting of a previous UKA.

3.
J Shoulder Elbow Surg ; 29(7S): S92-S100, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32643614

RESUMO

BACKGROUND: The management of high-grade acromioclavicular separations remains unclear. The surgical interventions have shifted to more anatomic, less invasive techniques. The purpose of this study was to systematically review the outcomes and complications of anatomic coracoclavicular ligament reconstruction using a tendon graft. METHODS: Twenty-one studies (n = 460 patients) met the criteria for inclusion. A double clavicle tunnel tendon graft construct was used in 348 patients (75.7%), whereas a single clavicle tunnel technique was used in 112 patients (24.3%). No significant difference in loss of reduction was found between the 2 techniques. Of 460 patients, 96 (20.9%) demonstrated some form of radiographic displacement at the final follow-up. The overall complication rate was 21.3% (98 of 460), and a higher complication rate was found in the double clavicle tunnel technique (P < .001). The overall reoperation rate was 7.6% (37 of 460). The most common reason for reoperation was clavicle fracture (8 of 37). There was a statistically significant increase in reoperation when allograft was used (P = .003). CONCLUSION: The results of this study suggest that despite newer techniques, approximately 20% of patients develop loss of reduction and/or experience a surgical complication. Attempts to minimize trauma to the clavicle and use autograft tendon may reduce the risk of reoperation.


Assuntos
Articulação Acromioclavicular/cirurgia , Artroplastia/métodos , Luxações Articulares/cirurgia , Ligamentos Articulares/cirurgia , Tendões/transplante , Aloenxertos , Artroplastia/efeitos adversos , Autoenxertos , Clavícula/lesões , Clavícula/cirurgia , Fraturas Ósseas/cirurgia , Humanos , Luxações Articulares/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Reoperação
4.
Am J Sports Med ; 48(3): 682-688, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31999469

RESUMO

BACKGROUND: Ultrasound-guided fascia iliaca blocks have been used for pain control after hip arthroscopy. There is little evidence regarding their effectiveness in comparison with other pain control modalities in patients who have undergone hip arthroscopy. PURPOSE: To compare the efficacy of ultrasound-guided fascia iliac block with intra-articular ropivacaine in controlling pain after hip arthroscopy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: Between 2015 and 2017, patients (N = 95) undergoing hip arthroscopy were randomly assigned to 2 groups. The first group received an ultrasound-guided fascia iliaca block with 50 to 60 mL of 0.35% ropivacaine. The second group received an intra-articular injection of 20 mL of 0.5% ropivacaine at the completion of the surgical case. Primary outcomes were postoperative pain scores in the recovery room; at postanesthesia care unit (PACU) discharge; and at 2 weeks, 6 weeks, and 3 months. Secondary outcomes included intraoperative and PACU narcotic usage (converted to morphine equivalent use) as well as readmission rates, PACU recovery time, and postoperative nausea and vomiting. RESULTS: Postoperative pain across all points did not significantly differ between the groups. Intraoperative and PACU narcotics did not differ significantly between the groups. Readmission rates, PACU recovery time, and postoperative nausea and vomiting did not significantly differ between the groups. There were no associated complications in either group. CONCLUSION: Ultrasound-guided fascia iliaca block for hip arthroscopy had no clinical advantage when compared with onetime intra-articular ropivacaine injection. REGISTRATION: NCT02365961 (ClinicalTrials.gov identifier).


Assuntos
Artroscopia/métodos , Bloqueio Nervoso/métodos , Dor Pós-Operatória/etiologia , Ropivacaina/administração & dosagem , Adulto , Artroscopia/efeitos adversos , Fáscia , Feminino , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Bloqueio Nervoso/efeitos adversos , Estudos Prospectivos , Ultrassonografia de Intervenção , Adulto Jovem
5.
Orthop Rev (Pavia) ; 8(1): 6253, 2016 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-27114811

RESUMO

Dislocation of the hip is a well-described event that occurs in conjunction with high-energy trauma or postoperatively after total hip arthroplasty. Bigelow first described closed treatment of a dislocated hip in 1870, and in the last decade many reduction techniques have been proposed. In this article, we review all described techniques for the reduction of hip dislocation while focusing on physician safety. Furthermore, we introduce a modified technique for the reduction of posterior hip dislocation that allows the physician to adhere to the back safety principles set for by the Occupational Safety and Health Administration.

6.
Biophys J ; 93(10): 3491-503, 2007 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-17693462

RESUMO

Docosahexaenoic acid-containing phosphoglycerides accumulate preferentially in membranes of the retina, brain, and spermatozoa, but the functional significance of this largely remains to be determined. Previously we compared the physical properties of homogeneous monolayers of these and other phosphoglyceride species to obtain insights into their physiological roles. Particularly noteworthy were the unusually low dipole moments of species having sn-2-docosahexaenoyl chains. In this study, we have investigated the electrostatic and lateral packing properties of related phosphoglycerides and found that: 1), The dipole moment-lowering effect of the docosahexaenoyl group arises from its having a Z double bond at chain position n-3. 2), The large dipole moment-lowering effects at sn-1 of an ether bond to an alkyl or a 1Z alkenyl chain and that of a sn-2-esterified n-3 fatty acid are additive. 3), The 1Z double bond in an alkenyl chain lowers the molecular area of a phosphoglyceride and, concomitantly, makes it less compressible. 4), Ethanolamine-containing phosphoglycerides are generally less compressible than their corresponding choline analogs. Our data showing that relatively small lipid structural changes markedly alter lipid physical properties in fluid phases underscores the need to study the function of peripheral and integral membrane proteins in the presence of appropriate lipid species.


Assuntos
Biofísica/métodos , Glicerofosfolipídeos/química , Ácidos Docosa-Hexaenoicos/química , Bicamadas Lipídicas/química , Lipídeos/química , Lipídeos de Membrana/química , Proteínas de Membrana/química , Conformação Molecular , Fosfolipídeos/química , Pressão , Eletricidade Estática , Propriedades de Superfície , Temperatura
7.
Sci STKE ; 2006(321): pe6, 2006 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-16467193

RESUMO

The omega-3 fatty acid docosahexaenoic acid (DHA n-3) has long been known to be a major component of phosphoglycerides in the gray matter of mammalian brains. Furthermore, early studies of synaptosomes that had been isolated from gray matter showed that the plasma membranes of the synaptosomes contained DHA n-3 that was selectively esterified to phosphatidylethanolamine, plasmenylethanolamine (alkenylacyl-glycero-phosphorylethanolamine), and phosphatidylserine. In contrast, the phosphatidylcholine in these membranes contained esterified oleic acid, and the sphingomyelin and glycolipids in the membranes contained amide-linked stearic acid instead of a mixture of this acid with other, amide-linked fatty acids. The full implications of this unusual distribution of lipid head groups, esterified fatty acids, and amide-linked fatty acids are unclear, but the phosphoglycerides and sphingosine-containing lipids appear to be distributed asymmetrically between the two leaflets of the plasma membrane lipid bilayer and are likely to contribute to a dynamic lipid substructure. Because very few neuronal plasma membranes have been isolated and characterized to date, a major challenge for the future will be to investigate the composition of the lipid bilayers of different neuronal plasma membranes and identify effects of DHA n-3-containing phosphoglycerides on the ability of the plasma membranes to perform their many different functions. The aim of this Perspective is to stimulate further work in this important area by discussing recent evidence related to the role of neuronal plasma membrane phosphoglycerides in cell signaling.


Assuntos
Ácidos Docosa-Hexaenoicos/metabolismo , Lipídeos de Membrana/fisiologia , Neurônios/fisiologia , Animais , Células CHO , Linhagem Celular Tumoral/efeitos dos fármacos , Córtex Cerebral/enzimologia , Cricetinae , Cricetulus , Meios de Cultura Livres de Soro/farmacologia , Ácidos Docosa-Hexaenoicos/farmacologia , Ácidos Graxos Insaturados/metabolismo , Ácidos Graxos Insaturados/farmacologia , Glicerofosfolipídeos/metabolismo , Fator de Crescimento Insulin-Like I/farmacologia , Mamíferos/metabolismo , Camundongos , Neuroblastoma/patologia , Neurônios/enzimologia , Transferases de Grupos Nitrogenados/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Proteínas Proto-Oncogênicas c-raf/metabolismo , Ratos , Serina/farmacologia , Espectrina/metabolismo , Especificidade por Substrato
8.
Biophys J ; 85(4): 2384-96, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-14507702

RESUMO

Mammalian synaptic membranes appear to contain high proportions of specific, sn-1-stearoyl-2-docosahexaenoyl- and sn-1-stearoyl-2-arachidonoyl phosphoglycerides, but the structural significance of this is unclear. Here we used a standardized approach to compare the properties of homogeneous monolayers of the corresponding phosphatidylcholines, phosphatidylethanolamines, phosphatidylserines, and phosphatidic acids with those of control monolayers of sn-1-stearoyl-2-oleoyl- and sn-1-palmitoyl-2-oleoyl phosphoglycerides. Major findings were: 1), that the presence of an sn-2-docosahexaenoyl group or an sn-2-arachidonoyl group increases the molecular areas of phosphoglycerides by 3.8 A(2) (7%) relative to the presence of an sn-2-oleoyl group; 2), that the phosphorylcholine headgroup independently increases molecular areas by a larger amount, 7.1 A(2) (13%); and 3), that the dipole moments of species having an arachidonoyl moiety or an oleoyl moiety are 83 mD (19%) higher than those of comparable docosahexaenoic acid-containing phosphoglycerides. These and other results provide new information about the molecular packing properties of polyenoic phosphoglycerides and raise important questions about the role of these phosphoglycerides in synapses.


Assuntos
Ácidos Docosa-Hexaenoicos/química , Eletroquímica/métodos , Glicerofosfolipídeos/química , Lisofosfatidilcolinas/química , Magnésio/química , Fluidez de Membrana , Lipídeos de Membrana/química , Fosfatidilcolinas/química , Membranas Sinápticas/química , Glicerofosfolipídeos/classificação , Substâncias Macromoleculares , Conformação Molecular , Tensão Superficial
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