Time Perspective as a Mediator of Depressive Symptoms in Patients with Polycystic Ovary Syndrome.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a chronic endocrinopathy characterized by oligo- or anovulation, clinical and/or biochemical markers of hyperandrogenism, and polycystic ovaries, and it is associated with an increased prevalence of depression. Research conducted on psychiatric patients has shown correlations between depression and decreased cognitive function. The aim of this study was to examine the possible mediation of the time perspective (TP) in the development of depressive symptoms in patients with PCOS. METHODS: A study was conducted on 83 patients with PCOS and 65 healthy women. Standardized questionnaires were used to assess depressive symptoms (Beck Depression Inventory-BDI-II) and time perspective (Zimbardo Time Perspective Inventory-ZTPI). RESULTS: Our study revealed an indirect influence of depressive symptoms on PCOS through the positive future time perspective. In the logistic regression model, which included depression and a given time perspective as predictors of PCOS, only the future TP (ß = -0.004, p < 0.003, OR = 1.004, 95% CI [1.001, 1.008]) was significantly independently related to the occurrence of PCOS. CONCLUSIONS: Our result is another argument for the role of psychoeducation and appropriate communication with a patient from the risk group in a way that builds hope and allows to regain influence on life situation.

Disparate Relationship of Sexual Satisfaction, Self-Esteem, Anxiety, and Depression with Endocrine Profiles of Women With or Without PCOS.

Women with polycystic ovary syndrome (PCOS) are at increased risk of psychological distress including anxiety and depressive symptoms. However, less is known about sexual satisfaction and self-esteem as well as the relationship of these aspects of psychological function with clinical and hormonal profiles associated with PCOS. This cross-sectional study compared women with PCOS (N = 96) and healthy controls (N = 47). This study assessed sexual function (primary outcome), self-esteem, anxiety, and depression as well as evaluation of clinical, endocrine, and metabolic parameters. Overall, sexual satisfaction scores were comparable among women with and without PCOS. However, psychosexual function of women with PCOS exhibited distinguishing characteristics. The unconscious aspect of sexuality: frequency of erotic dreams, significantly correlated with free testosterone (ρ = 0.24, P = 0.03) and DHEAS (ρ = 0.31, P = 0.004) only in the PCOS group. In contrast, in women with PCOS, the frequency of masturbation did not correlate with endocrine profiles, but correlated with trait anxiety (ρ = 0.21, P = 0.049) and depression (ρ = 0.21, P = 0.05). Only one aspect of self-esteem (body appearance) was reduced in the PCOS group (P = 0.02) and was related to BMI and androgen. Women with PCOS had greater state anxiety (P = 0.02) and depression (P < 0.001); these scores correlated with BMI. However, anxiety and depression correlated with testosterone only in women without PCOS. The above findings indicate that PCOS is associated with a broad range of alterations of psychological function including psychosexual aspects; these alterations are in complex relationship with BMI and androgen levels.

Postpartum depression - a medical or a social problem?

Objective: The aim of the study was to identify a group of women needed psychological support after delivery by identifying the medical and social factors that may influence the emotional changes during the postpartum period.Materials and method: A group of 835 pregnant women in second, third trimester of pregnancy, and during the postpartum period completed the Edinburgh Postnatal Depression Scale and the questionnaire consisting of difficulties that might occur in the four life fields: practical, family, emotional, and physical. The calculations have been carried out with the statistical package Statistica v10 and Cytel Studio v 9.0.0. At the Faculty of Information Science and Statistics of the Poznan University of Medical Sciences.Results: There is a series of medical and social risk factors potentially increasing the risk of postpartum depression, such as psychiatric disorders in the past, difficulties in the professional work, unsatisfactory relationship with partner, and others.Conclusions: Having selected a group of women with risk factors it seems reasonable to apply the Edinburgh Postnatal Depression Scale.

Psychiatric disorders in women with polycystic ovary syndrome. / Wystepowanie zaburzen psychicznych u kobiet z zespolem policystycznych jajników.

Polycystic ovary syndrome (PCOS) is the most commonly diagnosed endocrine disorder in women of reproductive age, affecting approximately 5-8% of females in this group. It is characterized by hyperandrogenism, abnormal periods (rare periods or amenorrhea) and polycystic ovaries visualized through ultrasonography. The etiopathogenesis of polycystic ovary syndrome has not been elucidated in detail. There are numerous hypotheses on this subject which tend to complement one another. The most widely recognized hypothesis is that the development of PCOS is due to insulin resistance and hyperinsulinemia, which subsequently lead to hyperandrogenism. On the basis of an as of yet relatively small number of studies, an increased prevalence of various psychiatric disorders can be observed in women with PCOS. These include: depression, generalized anxiety disorder, personality disorders, social phobia, obsessive-compulsive disorder, attention deficit hyperactivity disorder (ADHD), and eating disorders. Bipolar affective disorder, schizophrenia and other psychotic disorders have also been reported in women with PCOS more often than in the general population. The higher prevalence of psychiatric disorders in patients with PCOS, especially depression and anxiety disorders, may be due to both hyperandrogenism and the resulting somatic symptoms. These symptoms can undoubtedly be stigmatizing for women and lower their quality of life. This article is intended to provide an overview of the literature regarding mental disorders associated with polycystic ovary syndrome and to present own research on depression and sexual dysfunction in this group.

Determinants of emotional problems and mood disorders in women with polycystic ovary syndrome.

OBJECTIVES: The aim of the study was to assess the prevalence and severity of emotional problems among Polish women with polycystic ovary syndrome (PCOS) and seek factors which increase the risk of their occurrence. MATERIAL AND METHODS: The study group consisted of 82 women (aged 18-48), who were diagnosed with PCOS based on the Rotterdam criteria. During hospitalization, the patients completed a number of questionnaires, providing their sociodemographic data and information concerning the inconvenience of disease-associated symptoms. The question-naires included the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Multidimensional Self-Esteem Inventory (MSEI). Data obtained during medical examinations (blood tests, transvaginal ultrasound, height and body mass measurements) were analyzed. RESULTS: Out of 82 women, the results detected risk for depression in 42 (51.22%), mild depressive disorders in 32, moderate disorders in 8, and severe disorder in 2 patients. No statistically significant correlation between BDI or state anxiety and the level of the analyzed hormones, insulin resistance, or infertility treatment, was found. General self-esteem, trait anxi-ety, and marital status were associated with the occurrence of depression symptoms. BMI was associated with the level of state anxiety during hospitalization. CONCLUSIONS: Women with PCOS are at risk for mood and anxiety disorders. Disease-related somatic factors are not directly associated with the risk for disorder occurrence. However, severity of depression symptoms has been shown to be influenced by permanent psychological characteristics of the studied women, i.e. self-esteem, trait anxiety, and life situation (marital status). Therefore, it is recommended to include interviews about patient life situation and screening questionnaires for assessing depression into the diagnostic procedures in PCOS patients. Patients should be referred for a psychological or psychiatric consultation, if needed.