[Thoracoscopy in combined treatment of thymoma (in Russian only)]. / Videotorakoskopiia v kombinirovannom lechenii timom.

The experience of video-assisted thoracoscopic interventions for thymus tumors in the Research Institute of Oncology of Tomsk National Research Medical Center is presented. We also evaluate the features of postoperative management of these patients.

[Enzymes of estrogen metabolism in breast cancer and their correlation with outcome].

The biopsy samples of 85 patients with breast cancer (BC) stage T1-3N0-3M0 were studied for estrogen metabolism enzymes (aromatase, 2,4-estrogene hydroxylase and gluthathion transferase) activity. This data was analyzed in relation to disease outcome. Aromatase activity in cancer tissue less than 20 fmol/ mg protein/h and 2,4-estrogene hydroxylase activity more than 230 pmol/mg protein/h proved to be the independent and significant predictors associated with worse relapse-free survival. The activity of gluthathiontransferase in tumor tissue less than 40 mkmol/mg protein/h is associated with worse metastatic-free survival. The activities of estrogen metabolism enzymes may be used as additional prognostic markers for breast cancer outcome.

[Occult multicentric breast cancer].

The study included 92 patients with invasive ductal breast cancer (T2-4N0-2M0-1). In 38 cases, tumor growth was unicentric while histologically identifiable ones as multicentric in 44. Multicentricity mostly occurred in cases of macroscopically-identifiable nodes located in the central segments of the breast. Clinically-identifiable nodes of multicentric tumor growth measured more than 3 cm. Multicentric tumors were mostly grade III, featured lower expression of sex hormone receptors and positive Her2 status.