[Characteristics of the course and treatment of pulmonary tuberculosis associated with nonspecific respiratory diseases in children]. / Osobennosti techeniia i lecheniia tuberkuleza legkikh u detei pri sochetanii ego s nespetsificheskimi zabolevaniiami organov dykhaniia.

Specific features of intrathoracic tuberculosis course, outcomes and treatment are outlined for 109 children. In 59 of them tuberculosis was associated with nonspecific respiratory diseases (NRD). 28.8%, 25.4%, 18.6, 27.2% of patients had cystic hypoplasia, chronic hypoplasia, recurrent pneumonia, recurrent bronchitis, respectively. Complicated course of tuberculosis occurred 2 times more frequently in its combination with NRD (71.2%). Destruction and discharge of bacteria were recorded in 49.2 and 47.5% of patients, respectively. Undulating running was 3.4 and side effects 1.6 times more frequent. Tuberculous children with NRD need longer antituberculous therapy using wide-spectrum antibiotics, symptomatic and exercise treatment, massage, surgical intervention if necessary. Complete resolution of lung lesions in NRD children were seen 4.8 times less frequently. In case of late diagnosis 54% of them retained residual changes in the form of lung tissues fibrosis, calcified foci in the lungs and lymph nodes.

[New methods of prevention, diagnosis and treatment of tuberculosis in children]. / Novye metody profilaktiki, diagnostiki i lecheniia tuberkuleza u detei.

The follow-up included two groups of schoolchildren: 862 were repeatedly given BCG and 725, BCG-M vaccines. It was demonstrated that both vaccines had the same effectiveness and the latter could also be used. Upright tomographic findings in 70 children showed that it was highly informative for the diagnosis of intrathoracic tuberculosis in children, especially for that of bronchoadenitis. Monitoring of 315 children with destructive pulmonary processes (157 of them had lesions of tuberculous etiology) made it possible to define risk factors of destructive tuberculosis contamination (in particular, genetical predisposition), the diagnostic criteria and high diagnostic value of the enzyme-linked immunoassay (96%). Ultrasound examination of the liver in 121 tuberculosis children enabled one to diagnose the type and etiology of liver affection, to control its state during treatment, to specify the side effects of the drugs and to modulate the therapy. The course and outcomes of tuberculosis were found to be affected by liver affections. The parenteral administration of isoniazid in combination with other drugs was shown to be highly beneficial in disseminated form of tuberculosis in children.