Vacunación antigripal como medida más efectiva para hacer frente al impacto clínico y económico de la gripe / Flu vaccination as the most effective measure to face the clinical and economic impact of the complaint

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Vacunación frente al neumococo en adultos mayores de 65 años / Pneumococcal vaccine for adults over 65

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Evaluación económica de la vacunación frente al neumococo en mayores de 65 años de Castilla y León / Economic evaluation of pneumococcal vaccination in adults aged over 65 years in Castilla y León (SPAIN)

Introducción: La carga de enfermedad por neumonía en adultos mayores supone un impacto de gran magnitud en los sistemas de salud. El objetivo de este trabajo es realizar una evaluación económica de la estrategia de vacunación frente a Streptococcus pneumoniae mediante la vacuna neumocócica conjugada 13-valente frente a la no vacunación. Material y métodos: Se ha desarrollado un modelo económico simulado en forma de árbol de decisión para evaluar el coste/efectividad de la estrategia de vacunación en la cohorte de población mayor de 65 años del Área de Salud de Valladolid-Este versus no vacunación mediante un análisis probabilístico de Monte Carlo. Resultados: Streptococcus pneumoniae origina anualmente en el Área de Salud Valladolid-Este un total de 557,24 casos de enfermedad neumocócica, de los cuales 506,60 episodios son cuadros neumónicos. A partir del tercer año, la vacunación a la población mayor de 65 años es una medida eficiente, con un coste por años de vida ajustados por calidad (AVAC) de 20.496,20 Euros. El número de AVAC ganados en una década es de 86,07 y se evitaría el gasto de 216.252,89 Euros con esta estrategia vacunal. Conclusiones: La evaluación de los diferentes costes incrementales (AVAC y euros) en los años de seguimiento pone de manifiesto que el programa de vacunación frente al neumococo a personas mayores de 65 años en Castilla y León es una medida coste eficiente

Introduction: The burden of disease due to pneumonia in older adults has a major impact on health systems. The aim of this study is to carry out an economic evaluation of the vaccination strategy against Streptococcus pneumoniae using the 13-valent pneumococcal conjugate vaccine. Material and methods: A simulated economic model has been developed in the form of a decision tree to evaluate the cost of the vaccination strategy in the population over 65 years of the Valladolid-East Health Area, versus non-vaccination, using a Monte Carlo probabilistic analysis. Results: Streptococcus pneumoniae annually generates 557.24 cases of pneumococcal disease in the Valladolid-East Health Area, and 506.60 episodes have pneumonia symptoms. Vaccination of the cohort over 65 years of age is an efficient measure from the third year, with a cost per quality-adjusted life years (QALY) of 20,496.20 Euros. The number of QALYs gained in a decade is 86.07 and an amount of 216.252.89 Euros with this vaccination strategy would be saved. Conclusions: The evaluation of the different incremental costs (QALY,euros) in the years of follow-up, the pneumococcus vaccination program in people over 65 in Castilla y León is cost-effective

[Economic evaluation of pneumococcal vaccination in adults aged over 65 years in Castilla y León (SPAIN)]. / Evaluación económica de la vacunación frente al neumococo en mayores de 65 años de Castilla y León.

INTRODUCTION: The burden of disease due to pneumonia in older adults has a major impact on health systems. The aim of this study is to carry out an economic evaluation of the vaccination strategy against Streptococcus pneumoniae using the 13-valent pneumococcal conjugate vaccine. MATERIAL AND METHODS: A simulated economic model has been developed in the form of a decision tree to evaluate the cost of the vaccination strategy in the population over 65 years of the Valladolid-East Health Area, versus non-vaccination, using a Monte Carlo probabilistic analysis. RESULTS: Streptococcus pneumoniae annually generates 557.24 cases of pneumococcal disease in the Valladolid-East Health Area, and 506.60 episodes have pneumonia symptoms. Vaccination of the cohort over 65 years of age is an efficient measure from the third year, with a cost per quality-adjusted life years (QALY) of 20,496.20 €. The number of QALYs gained in a decade is 86.07 and an amount of 216.252.89 € with this vaccination strategy would be saved. CONCLUSIONS: The evaluation of the different incremental costs (QALY,euros) in the years of follow-up, the pneumococcus vaccination program in people over 65 in Castilla y León is cost-effective.

Recogida de datos y control microbiológico para la intervención global de la tuberculosis / Data Collection And Microbiological Monitoring In Global Tuberculosis Intervention

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Dispositivos de bioseguridad y formación para prevenir las exposiciones biológicas accidentales en el ámbito hospitalario / Biosafety devices and training to prevent accidental biological exposures in hospitals

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Estrés en las Unidades de Intervención Policial / Police Intervention Units Stressed Out

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Relación predictiva para prevenir la violencia ocupacional en Atención Primaria / No disponible

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Gripe en pediatría: interrogantes y posibilidades / Flu in paediatrics: questions and possibilities

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[Burden of hospitalization for pneumonia in a Spanish tertiary hospital. Period 2009-2014]. / Carga de hospitalización por neumonía en un hospital terciario español. Período 2009-2014.

BACKGROUND: The aim of this paper is to estimate the burden of hospitalization for community-acquired pneumonia and pneumococcal pneumonia at a tertiary level hospital in the Spanish National Health System. METHODS: A retrospective study which compiles data from the Minimum Data Set using clinical codes of the International Code of Diseases, as well as the hospitalization rate index per thousand inhabitants, the hospitalization rate per thousand population, mortality and fatality rate, using as denominator the demographic data of the population of the Health Area. RESULTS: The discharge of 5758 episodes coded with CIE codes 480 to 486 related to pneumonia, indicates an hospitalization rate of 3.54 people hospitalized per 1000 inhabitants, 65.34 % of all hospital admissions occured in Internal Medicine Services and Pneumology. The average hospital stay per year is 16.63 days. The crude death rate is 69.15 per 100 000 inhabitants and the fatality rate is 19.56 % being higher in adults over 65 years. CONCLUSIONS: Despite the current therapeutic and preventive measures, the incidence and mortality of community-acquired pneumonia in adults remains high, which justifies the strengthening and awareness to address new strategies and prevention such as vaccination.

Introducción: el objetivo de este trabajo es estimar la carga de hospitalización por neumonía adquirida en la comunidad y neumonía neumocócica en un hospital de nivel terciario del Sistema Nacional de Salud Español. Métodos: estudio retrospectivo en el que se recogen los datos del Conjunto Mínimo de Datos Básicos que usa códigos clínicos del Código Internacional de Enfermedades, asi como el índice de hospitalización por mil habitantes, la tasa de hospitalización por mil habitantes, el índice de mortalidad y la tasa de letalidad, usando como denominador los datos demográficos de la población del Área de Salud. Resultados: la descarga de 5758 episodios codificados con los códigos CIE 480 a 486 relativos a neumonía, señalan un índice de hospitalización de 3.54 personas hospitalizadas por cada 1000 habitantes, 65.34% del total de ingresos hospitalarios se produce en los Servicios de Medicina Interna y de Neumología. La estancia media hospitalaria por año es de 16.63 días. La tasa bruta de mortalidad es de 69.15 cada 100 000 y la tasa de letalidad de 19.56%, siendo más elevadas en adultos mayores de 65 años. Conclusiones: a pesar de las medidas terapéuticas y preventivas actuales, la incidencia y la mortalidad por neumonía adquirida en la comunidad en adultos se mantienen elevadas, lo que justifica fortalecer y abordar nuevas estrategias de concienciación y prevención.

Pneumonia: burden of disease / Carga de enfermedad por neumonía

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Antimicrobial resistance in more than 100,000 Escherichia coli isolates according to culture site and patient age, gender, and location.

Escherichia coli and the antimicrobial pressure exerted on this microorganism can be modulated by factors dependent on the host. In this paper, we describe the distribution of antimicrobial resistance to amikacin, tobramycin, ampicillin, amoxicillin clavulanate, cefuroxime, cefoxitin, cefotaxime, imipenem, ciprofloxacin, fosfomycin, nitrofurantoin, and trimetoprim-sulfametoxazole in more than 100,000 E. coli isolates according to culture site and patient age, gender, and location. Bayesian inference was planned in all statistical analysis, and Markov chain Monte Carlo simulation was employed to estimate the model parameters. Our findings show the existence of a marked difference in the susceptibility to several antimicrobial agents depending on from where E. coli was isolated, with higher levels of resistance in isolates from medical devices, the respiratory system, and the skin and soft tissues; a higher resistance percentage in men than in women; and the existence of a clear difference in antimicrobial resistance with an age influence that cannot be explained merely by means of an increase of resistance after exposure to antimicrobials. Both men and women show increases in resistance with age, but while women show constant levels of resistance or slight increases during childbearing age and greater increases in the premenopausal age, men show a marked increase in resistance in the pubertal age. In conclusion, an overwhelming amount of data reveals the great adaptation capacity of E. coli and its close interaction with the host. Sex, age, and the origin of infection are determining factors with the ability to modulate antimicrobial resistances.

Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses.

This report evaluates the June 2008 onychomadesis outbreak in Valencia, Spain. The study sample consisted of 221 onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual pathological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, and B3; echoviruses 3, 4, and 9; and enterovirus 71 were present in low frequencies in the case and control groups (3-9%). The 2008 onychomadesis outbreak in the metropolitan area of Valencia was associated with an outbreak of hand, foot, and mouth disease primarily caused by coxsackievirus A10.