COVID-19 reinfection after pregnancy.

BACKGROUND: There have been reports of COVID-19 reinfections, but the immunological characterization of these cases is partial. We report a case of reinfection with SARS-CoV-2, where the first infection occurred in the course of late pregnancy. CASE PRESENTATION: On May 27, 2020, a 37-year-old woman gave birth at full term, 3 hours after full dilatation. She developed fever (38.3°C) after delivery. Mild biological anomalies compatible with COVID-19 were observed: lymphopenia, thrombocytopenia, elevated D-Dimers, CRP, and LDH. At 6-month follow-up, she reported having contracted COVID-19 with high fever, rhinorrhea, hand frostbites, cough, headache, dysgeusia and anosmia. CONCLUSIONS: We report a case of COVID-19 reinfection with a first mild infection during late pregnancy and a more aggressive second infection 5 months later.

[The role of a hospital-based registry of a regional cancer center for a population-based cancer registry]. / Intérêt des données du registre hospitalier (Enquête permanente cancer) d'un centre régional de lutte contre le cancer pour un registre de cancer en population.

BACKGROUND: Hospital-based cancer registries (HBR) of Comprehensive cancer centers (CCC) named "Enquête permanente cancer (EPC)" could represent an important information source of data for a population-based cancer registry (PBR). The main purpose of this study was to evaluate the concordance between data from HBR of the CCC for regions of Bordeaux and South-Western France and data from PBR of the General cancer registry of Gironde and the completeness for the year 2005, in order to explore the possibility for immediate integration of data collected by the HBR in the database of the PBR and to reduce the systematic consultation of medical records for cancer cases notified by the HBR. METHODS: We estimated the proportion of concordant cases between the HBR and the PBR and the unweighted and weighted Cohen's Kappa coefficient for certain variables. RESULTS: Among 1151 cases notified by the HBR, 1095 (positive predictive value of HBR: 95%) were included in the PBR database. For these admissible cases, sex, birth date and place for residence postal code at diagnosis were concordant in more than 94%. Concordance of cancer incidence date was 50% but difference between two dates was lower than 1 month in 91% of cases. Concordance of cancer topography and morphology was respectively 72% and 78%. Cancer progression, estimated by TNM classification was concordant in 96% of cases. The Kappa coefficient was 0.95 for pT, and respectively 0.92 for pN and M. CONCLUSION: Automatic data integration from the HBR database to the PBR database without consulting medical record will be possible in Gironde. But, topography and morphology will be systematically recoded using pathologist records. And, if cancer progression (coded by TNM classification) is missing in the HBR database, medical records will be consulted in order to complete this data in the PBR database.

[Evaluation of a new intraocular lens platform: centration and rotational stability]. / Évaluation d'une nouvelle plateforme d'implant intraoculaire: centrage et stabilité rotatoire.

PURPOSE: To assess the rotational stability and centration of a single-piece hydrophilic acrylic intraocular lens (IOL) during the first postoperative year. SETTING: Clinique Beausoleil, 117, avenue de Lodève, 34070 Montpellier, France. DESIGN: Retrospective case series. METHOD: The POD AY 26% monofocal aspheric yellow intraocular lens is designed to facilitate its intraoperative orientation within the capsular bag. This study consists of a retrospective analysis of 117 consecutive eyes implanted with this IOL to determine its postoperative stability. Data collected include ocular biometry, patient history, IOL power, pre- and postoperative visual acuity and refraction, and slit lamp photos after one and three weeks, and 3 and 12 months. RESULTS: Mean postoperative visual acuity was 0.95 after 3 months and remained stable after 1 year. The refraction was also stable over time, although a slight effect related to corneal healing could be observed (0.1D). The mean absolute rotation of the implant was 2.5 ± 2.6°. The position of the center of the implant relative to the pupillary center expressed as a vector was 0.01 mm at 70°. CONCLUSION: This new IOL design is as stable as a C-Loop IOL but provides much better maneuverability during implantation. It provides physiologic centration and good rotational stability over 1 year. It would be a perfect platform for a toric optic.

[Advantages of the bag-in-the-lens intraocular lens in pediatric cataract surgery]. / Intérêt de l'implant "bag-in-the-lens" dans la chirurgie de la cataracte de l'enfant.

OBJECTIVE: Evaluate the advantages of the bag-in-the-lens intraocular lens in children undergoing cataract surgery. PATIENTS AND METHODS: This prospective study included 54 eyes of 37 children and babies (age, 2 months to 14 years), consecutively operated on between December 1999 and January 2008 for unilateral or bilateral cataract using the "bag-in-the-lens" intraocular lens. Slit-lamp examination, intraocular pressure, visual acuity, and refraction were followed to the best possible degree over time. RESULTS: The mean age of the 37 children at the last consultation visit was 8.3+/-4.9 years. The mean visual acuity improved from 0.2+/-0.1 to 0.8+/-0.3. On the other hand, visual acuity improvement in children presenting hyperplastic persistence of the vitreous was less favorable with a postoperative average visual acuity of 0.14+/-0.18. The mean postoperative refraction in 13 children (26 eyes) operated on for bilateral cataract was 0.5+/-1.5 D for eyes showing axial lengths with substantial variation. The refraction was stable over time in children over 2 years of age. Once the implant was positioned correctly, the remaining epithelial cells of the lens did not migrate toward the visual axis, which was the case in 93.8% of all eyes and in 100% of children over 1 year of age. CONCLUSIONS: The "bag-in-the-lens" implant is particularly indicated in children in whom posterior rhexis and optic capture have been recommended since 1994. The implantation minimizes the use of anterior vitrectomy in pediatric cataract surgery, limiting it to those eyes presenting a proliferative hyperplastic vitreous.

[Treatment for combined hypermetropia and presbyopia with a gaussian broad beam Excimer Laser]. / Traitement combiné de l'hypermétropie et de la presbytie par un Laser Excimer à faisceau large gaussien.

AIM: To analyze the performances of the Inpro-Gauss Excimer laser in the treatment of hyperopia and combined hypermetropia-presbyopia. METHODS: The hypermetropic treatment consisted in making 12 confluent ablation spots of 3.3+/-0.1 mm at 4.5 mm from the corneal apex. The surgical parameters were simulated by a computer model of the corneal profile. The combined hypermetropic-presbyopic treatment was achieved by adding 4 spots of +2 D in the infero-nasal quadrant. Our series included forty eyes of which eleven were treated for hyperopia only and twenty nine were treated both for hyperopia and presbyopia. RESULTS: The uncorrected postoperative visual acuity was equivalent or better than the preoperative corrected visual acuity in 82% of cases. The averaged postoperative spherical equivalent was -0.2+/-0.5 D. Near uncorrected visual acuity was one line better (in decimal notation) for the group treated for both hyperopia and presbyopia than in the single hyperopia group. CONCLUSION: Surface laser treatment of hyperopia and presbyopia with a gaussian broad beam laser is safe, accurate and reproducible.

[Secondary cataract: a problem resolved]. / La cataracte secondaire: un problème résolu.

A new intraocular lens (LOL) aiming at eradicating posterior capsule opacification (PCO), the most common complication after cataract surgery, is proposed. The haptics of this new IOL are conceived to capture the remaining lens epithelial cells (LECs) left behind in the capsular equator after cataract surgery in a closed area in order not to allow them to proliferate into the visual axis. In order to facilitate the surgical technique, several devices have been developed. We showed the inocuity of this technique on postoperative inflammation and the low rate of postoperative complications. We obtained 0% PCO and in addition excellent refractive results. The results on children and babies were the most rewarding since none of these children presented PCO and accommodation was important enough as to allow reading without glasses.

Gaussian broad-beam excimer laser: clinical and experimental results.

PURPOSE: To evaluate the mid-term (1-3 years) results of the Gaussian broad-beam excimer laser Delivery System (DS) after single treatment for the correction of myopia. To study the corneal surface with scanning electron microscopy (SEM) after excimer laser ablation using a flying spot delivery system (Bausch & Lomb) and a Gaussian Delivery System (GDS) (InPro). METHODS: The 1035 consecutive eyes studied were split in four groups with respect to the treated myopia, expressed in spherical equivalent: low myopia up to -3.00 D (183 eyes), moderate myopia from -3.25 D to -6.00 D (540 eyes), high myopia from -6.25 D to -10.00 D (210 eyes) and very high myopia from -10.25 D to -20.00 D (102 eyes). Four post-mortem eyes of two donors were treated using the flying spot DS on one eye and the GDS on the other eye. RESULTS: We achieved postoperative spheriqual equivalent within +/- 1 D of emmetropia in respectively 99.1%, 98.9%, 83% and 21% of the eyes of group 1, 2, 3 and 4. UCVA was 10/10 or better in respectively 65%, 51% and 19% of group 1, 2 and 3. UCVA was 5/10 or better in respectively 86% and 75% of group 3 and 4. The defocus equivalent refraction was 1.0 or less in respectively 98%, 93%, 62%, and 7% of the four groups. On SEM, the corneal surface presented a smooth and polished profile for the GDS. CONCLUSIONS: The Gaussian Delivery System gives comparable results to the flying spot laser system for surface laser ablation in myopic eyes up to -10 D. Advantages of this system are: smooth ablation surface, short treatment time, low haze rate, high reliability and easy maintenance of the device due to the optical DS. It is an interesting alternative for the more complex mechanical DS.

[PRK with InPro-Gauss excimer laser: statistical analysis of results]. / PRK avec le laser excimer InPro-Gauss: analyse statistique des rèsultats.

PURPOSE: To analyse retrospectively the pre- and postoperative refraction and visual acuity according to Standard Graphs proposed by Waring for refractive surgery. METHODS: Ninety-three eyes with myopia ranging from -1.50 to -8 diopters (D) and/or with astigmatism ranging from 0.75 to 3 D were treated between July 1998 and June 2001. The laser delivers a broad beam with a regular gaussian energy repartition obtained by means of a plate containing an array of diffractive micro-lenses. RESULTS: The coefficient of linear correlation between the attempted and achieved spherical equivalent refraction was 0.97. A postoperative spherical equivalent refraction between -0.50 and +0.50 D was found in 92.3% of eyes. The defocus equivalent refraction (spherical refraction added to one-half of the cylindrical component, ignoring the sign) represents more accurately the reality of the refractive state, and in our study was within +/- 0.50 D for 86.4% of the eyes. A preoperative best corrected visual acuity of 10/10 was found in 78% of eyes and 64% achieved postoperatively an uncorrected visual acuity of 10/10. CONCLUSION: The InPro-Gauss excimer laser gives good refractive results. The Gauss profile delivery system provides reliability and quality of the ablated surface of cornea.

Integrating the digitized backscattered image to measure absorption and reduced-scattering coefficients in vivo.

Measurement of absorption and reduced-scattering optical coefficients microa and micros' is possible when a steady-state backscattered image is used on a sample surface. A new method for processing the backscattered image, acquired with a CCD, has been developed. The image is integrated to decrease sensitivity to noise. The resulting curve is defined as the integral reflectance. The curve is then fitted with a relaxation model to evaluate microa and micros'. We have validated the method with calibrated scattering and absorption phantoms. The integral reflectance method is then applied to measurements of the microa and micros' coefficients of human skin in vivo.