[Pharmacotherapy in sexual behavior disorders and intellectual disability]. / Farmacotherapie bij seksuele gedragsstoornissen en verstandelijke beperking.

BACKGROUND: Sexual behavior disorders in intellectual disability form several challenges, despite evolutions in treatment options and risk assessment. The use of antilibidinal pharmacotherapy in this population is controversial and research is inconclusive about the most appropriate treatment strategy. AIM: To highlight pharmacotherapeutic management of sexual behavior disorders in intellectual disability, its medical and ethical considerations. METHOD: A literature review to provide an overview of the available literature, which was elaborated based on clinical experience. RESULTS: We found a lack of scientific evidence on the efficacy of pharmacotherapy specifically for sexual behavior disorders in people with intellectual disabilities. The routine use of antilibidinal medication is contraindicated. Medical and ethical guidelines have been published as well as contraindications for initiating androgen deprivation therapy in the general population. The necessity of pharmacotherapy should be closely monitored and supplemented with psychotherapeutic care to cultivate the patient’s sexual skills, attitudes and knowledge. A distinction should be made between sexual behavior disorders of the ‘paraphilic type’ and of the ‘sexually maladjusted or naive type’. CONCLUSION: Multidisciplinary evaluation, risk assessment and an individualized approach are the cornerstones of high-quality treatment of sexual behavior disorders in persons with intellectual disability.

[Values under fire; ethics in forensic psychiatry]. / Waarden onder vuur; ethiek in de forensische psychiatrie.

BACKGROUND: Professionals in forensic psychiatry regularly face moral issues. For example, they have to make trade-offs between the treatment of a patient and society's security. AIM: To provide insight into some difficult, specifically forensic, dilemmas and show that forensic professionals benefit from structural ethics support. METHOD: Describing that ethics support, such as moral case deliberation, can provide support in making moral choices in forensic psychiatry. RESULTS: By participating in moral case deliberation, considerations are better substantiated and employees learn from and with each other. CONCLUSION: Moral case deliberation supports staff in jointly reflecting on moral dilemmas of the (forensic) workplace.

[Reaction on 'Does ambulantization lead to more imprisonment of psychiatric patients?'] / Reactie op 'Leidt ambulantiseren tot meer gevangenschap van psychiatrische patiënten?'.

Reaction on 'Does ambulantization lead to more imprisonment of psychiatric patients?'

[Education and training in psychiatry in 2019]. / Onderwijs en opleiding in de psychiatrie anno 2019.

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[Development of a forensic psychiatric curriculum in Belgium and the Netherlands]. / De ontwikkeling van een forensisch psychiatrisch curriculum in Vlaanderen en Nederland.

BACKGROUND: Forensic psychiatry attracts considerable attention from media and politicians. All psychiatrists, not only those working in the forensic field, should be able to evaluate safety for society on the one hand and qualitative health care for psychiatric patients on the other. However, little attention is paid to specific forensic issues, in both psychiatric training and in medical school.
AIM: To map relevant topics for a forensic psychiatric curriculum in medical schools and psychiatric residency training.
METHOD: The main findings regarding educational topics in forensic psychiatry are discussed based on policy papers and scientific articles.
RESULTS: Four important topics should be covered in general psychiatric training, i.e. mental health legislation, risk assessment and management, professionalism and ethics, and expert witness training. The Netherlands has a specific training programme for psychiatrists interested in expert report writing and testimony for criminal courts. In Belgium, psychiatrists can acquire specific professional competence in forensic psychiatry.
CONCLUSION: Acknowledgement of the above-mentioned topics in the general medical and psychiatric curriculum will lead to better knowledge and competencies for all psychiatrists, both in Belgium and the Netherlands. Continuing attention and evaluation will be necessary given the high societal relevance.

Assessment of acute kidney injury in canine parvovirus infection: Comparison of kidney injury biomarkers with routine renal functional parameters.

Dogs with naturally occurring canine parvovirus (CPV) infection are at risk of developing acute kidney injury (AKI) due to several factors, including severe dehydration, hypotension and sepsis. Serum creatinine (sCr) and serum urea are insensitive markers for the assessment of early kidney injury. Therefore, the aim of this study was to investigate potential kidney injury in dogs with CPV infection using both routine renal functional parameters and several kidney injury biomarkers. Twenty-two dogs with CPV infection were prospectively enrolled and compared with eight clinically healthy control dogs. Urinary immunoglobulin G (uIgG) and C-reactive protein (uCRP) were measured to document glomerular injury, whereas urinary retinol-binding protein (uRBP) and neutrophil gelatinase-associated lipocalin (uNGAL) served as markers for tubular injury. These biomarkers were compared to routine renal functional parameters, including sCr, serum urea, urinary protein:creatinine ratio (UPC) and urine specific gravity (USG). Dogs with CPV infection had significantly higher concentrations of uIgG, uCRP, uRBP and uNGAL compared to healthy dogs. In contrast, sCr was significantly lower in dogs with CPV infection compared to controls, while serum urea was not significantly different. UPC and USG were both significantly higher in CPV-infected dogs. This study demonstrated that dogs with CPV infection had evidence of AKI, which remained undetected by the routine functional markers sCr and serum urea, but was revealed by UPC, uIgG, uCRP, uRBP and uNGAL. These results emphasize the added value of novel urinary kidney injury biomarkers to detect canine patients at risk of developing AKI.

[Personalised medicine in forensic psychiatry: an example for other domains of psychiatry?] / Personalised medicine in de forensische psychiatrie: een voorbeeld voor andere domeinen in de psychiatrie?

BACKGROUND: Personalised medicine promises to provide us with a diagnostic predictive system of stratification that is based on a wide variety of tests; these can include biological, cognitive, demographic, psychopathological tests and other clearly defined tests. The purpose of forensic psychiatry is not only to take care of and treat mentally impaired patients but also to engage in risk assessment and risk management.
AIM: To explain risk assessment in forensic psychiatry as a nomothetic approach to personalised medicine, and also to demonstrate the link with offence paralleling behaviour, which is an illustration of the ideographic approach.
METHOD: A discussion of recent literature and insights into risk assessment, risk management and offence paralleling behaviour.
RESULTS: Risk assessment helps us to divide patients into groups according to the risk of recidivism. The nomothetic concept is the basis of most risk assessment instruments. One of the most important tasks in risk management in forensic psychiatry is to reduce the risk factors and strengthen the influence of protective factors. The model of offence paralleling behaviour resembles in many respects the concept of integrating risk management and treatment, but shows more precisely how hypotheses can be tested in a clinical context.
CONCLUSION: In view of the great importance to society of preventing offences, forensic psychiatry is leading the way in the application of personalised medicine in psychiatry.

Spinal Arachnoid Diverticula: Outcome in 96 Medically or Surgically Treated Dogs.

BACKGROUND: Little is reported about the role of medical management in the treatment of spinal arachnoid diverticula (SAD) in dogs. OBJECTIVES: To describe the outcome of 96 dogs treated medically or surgically for SAD. ANIMALS: Ninety-six dogs with SAD. METHODS: Retrospective case series. Medical records were searched for spinal arachnoid diverticula and all dogs with information on treatment were included. Outcome was assessed with a standardized questionnaire. RESULTS: Fifty dogs were managed medically and 46 dogs were treated surgically. Dogs that underwent surgery were significantly younger than dogs that received medical management. No other variables, related to clinical presentation, were significantly different between both groups of dogs. The median follow-up time was 16 months (1-90 months) in the medically treated and 23 months (1-94 months) in the surgically treated group. Of the 38 dogs treated surgically with available long-term follow-up, 82% (n = 31) improved, 3% (n = 1) remained stable and 16% (n = 6) deteriorated after surgery. Of the 37 dogs treated medically with available long-term follow-up, 30% (n = 11) improved, 30% (n = 11) remained stable, and 40% (n = 15) deteriorated. Surgical treatment was more often associated with clinical improvement compared to medical management (P = .0002). CONCLUSIONS AND CLINICAL IMPORTANCE: The results of this study suggest that surgical treatment might be superior to medical treatment in the management of SAD in dogs. Further studies with standardized patient care are warranted.

Predictive equations of selenium accessibility of dry pet foods.

The trace element selenium is essential to both dogs and cats. Dry diets are formulated with a large range of ingredients, which may vary in selenium concentration and accessibility. This paper reports equations to predict the average in vitro selenium accessibility from dry pet foods based on essential dietary nutrient concentrations, including crude protein, amino acids and crude fat. Predictive equations were made using stepwise linear regression for extruded and pelleted diets. The equations can be used to aid diet formulation to optimize selenium accessibility within the diet and to prevent selenium deficiency or toxicity.

[Mandatory treatment of forensic psychiatric patients in the Netherlands: costs and benefits in perspective]. / De tbs-maatregel: kosten en baten in perspectief.

BACKGROUND: So far, it is not known what costs and benefits are connected with the tbs-measure, a measure that involves a mandatory treatment programme for forensic psychiatric patients.
AIM: To explore the costs and benefits that the tbs-measure has on society, on other important stakeholders such as victims and/or next-of-kin and the forensic psychiatric patients themselves.
METHOD: We studied the relevant literature.
RESULTS: The average costs of the tbs-treatment programme are 1.5 million euros. Additional costs result from recidivism among patients after tbs-treatment. Of these, 21.2% commit another serious offence after 9 years; this recidivism rate is much lower than rates for former offenders who have not received tbs-treatment (63.8%). Other costs arise through the impact that crimes have on stake-holders. Among the benefits of the tbs-programme are a reduction in psychopathological symptoms and in risk factors and lower recommitment rates (including judicial, non-judicial, voluntary and mandatory recommitment rates). Yet another benefit is the resultant increase of protective factors.
CONCLUSION: Forensic psychiatric patients form a unique group within the mental health system in the Netherlands; these patients have multiple complex psychiatric problems and display serious criminal behavior. This group cannot easily be treated elsewhere in the existing judicial or mental health care system because these systems differ in (judicial) frameworks and have different treatment goals, and the forensic psychiatric patients have different psychiatric disorders and display more serious criminal behaviour than patients in the alternative systems. The daily costs of treatment in the tbs-system are higher that in other systems - but they are not exorbitant, given the complexity of the group. The tbs-measure therefore contributes to the safety of society.

Assessment of welfare of Brazilian and Belgian broiler flocks using the Welfare Quality protocol.

The Welfare Quality consortium has proposed a science-based protocol for assessing broiler chicken welfare on farms. Innovative features make the protocols particularly suited for comparative studies, such as the focus on animal-based welfare measures and an integration procedure for calculating an overall welfare status. These protocols reflect the scientific status up to 2009 but are meant to be updated on the basis of inter alia implementation studies. Because only few such studies have been done, we applied the Welfare Quality protocol to compare the welfare of broiler flocks in Belgium (representing a typical European Union (EU) country which implies stringent animal welfare legislation) versus Brazil (the major broiler meat exporter to the EU and with minimal animal welfare legislation). Two trained observers performed broiler Welfare Quality assessments on a total of 22 farms in Belgium and south Brazil. All of the farms produced for the EU market. Although the overall welfare was categorized as 'acceptable' on all farms, many country differences were observed at the level of the welfare principles, criteria, and measures. Brazilian farms obtained higher scores for 3 of the 4 welfare principles: 'good feeding' (P = 0.007), 'good housing' (P < 0.001), and 'good health' (P = 0.005). Four of the 10 welfare criteria scores were, or tended to be, higher on Brazilian than Belgian farms: 'absence of prolonged thirst' (P < 0.001), 'ease of movement' (P < 0.001), 'absence of injuries' (P = 0.002), and 'positive emotional state' (P = 0.055). The only criteria with a higher score for the Belgian farms than their Brazilian counterparts were 'absence of prolonged hunger' (P = 0.048) and 'good human-animal relationship' (P = 0.002). Application of the Welfare Quality protocol has raised several concerns about the validity, reliability, and discriminatory potential of the protocol. The results also call for more research into the effect of animal welfare legislation as broiler welfare on the south Brazilian farms appeared to be superior to that on the Belgian farms. Animal-based welfare assessments on a larger sample of farms are needed to evaluate to what extent these findings may be generalized.