[Hidradenitis suppurativa. Response to treatment with infliximab]. / Hidrosadenitis supurativa. Respuesta al tratamiento con infliximab.

INTRODUCTION: Hidradenitis suppurativa is a chronic inflammatory disease that runs in outbreaks with painful lesions, fistulas and scars in axillae, groins, buttocks, and perianal and submammary regions. Among multiple drug therapies available, infliximab, usually employed in dermatology to control psoriasis, has shown its efficacy in the past five years. PATIENTS AND METHOD: It is a prospective, observational study to determine the efficacy and safety of infliximab in the treatment of hidradenitis suppurativa. We selected three women with a history of hidradenitis suppurativa of more than 10 years, with involvement of at least two anatomic locations that was recalcitrant to conventional therapies. Each patient received infliximab at a dose of 5mg/kg/infusion on weeks 0, 2, 6 and every 8 weeks thereafter. RESULTS: Two of the three patients showed mild to moderate improvement of their disease while the third patient did not improve. We can highlight the variability of the results observed in these three patients. Adverse effects were generally mild and well tolerated by the three patients. Despite this, two patients withdrew the therapy due to loss of efficacy in one case and the development of generalized arthalgias in the other case. CONCLUSIONS: Treatment of hidradenitis supurativa with infliximab constitutes a moderately useful alternative in some cases.

Hidrosadenitis supurativa. Respuesta al tratamiento con infliximab / Hidradenitis supurativa. Response to treatment with infliximab

Introducción. La hidrosadenitis supurativa es una enfermedad inflamatoria crónica, que cursa en brotes, con lesiones dolorosas, fístulas y cicatrices en axilas, ingles, glúteos, región perianal e inframamaria. Entre los múltiples tratamientos farmacológicos disponibles, en los últimos cinco años se ha demostrado la eficacia del infliximab, un tratamiento habitualmente utilizado en dermatología para el control de la psoriasis. Pacientes y método. Estudio prospectivo, observacional, realizado con el objetivo de determinar la eficacia y seguridad del infliximab en el tratamiento de la hidrosadenitis supurativa. Tres pacientes mujeres con hidrosadenitis supurativa de más de 10 años de evolución, con afectación de al menos dos localizaciones anatómicas y resistente a terapias convencionales. Se realiza tratamiento con infliximab a cada una de las pacientes en dosis de 5 mg/kg/infusión en las semanas 0, 2, 6 y posteriormente cada 8 semanas. Resultados. Dos de las tres pacientes presentaron una mejoría leve-moderada de su enfermedad, mientras que la tercera paciente no obtuvo mejoría. Podemos destacar la variabilidad de los resultados observada entre las tres pacientes. Los efectos secundarios fueron en general leves y bien tolerados por las tres pacientes. Pese a ello, dos de las pacientes tuvieron que suspender el tratamiento debido a la falta de eficacia del mismo en uno de los casos y a un cuadro de artralgias generalizadas en otro. Conclusiones. El tratamiento de la hidrosadenitis supurativa con infliximab constituye una alternativa moderadamente útil en algunos casos

Introduction. Hidradenitis suppurativa is a chronic inflammatory disease that runs in outbreaks with painful lesions, fistulas and scars in axillae, groins, buttocks, and perianal and submammary regions. Among multiple drug therapies available, infliximab, usually employed in dermatology to control psoriasis, has shown its efficacy in the past five years. Patients and method. It is a prospective, observational study to determine the efficacy and safety of infliximab in the treatment of hidradenitis suppurativa. We selected three women with a history of hidradenitis suppurativa of more than 10 years, with involvement of at least two anatomic locations that was recalcitrant to conventional therapies. Each patient received infliximab at a dose of 5mg/kg/infusion on weeks 0, 2, 6 and every 8 weeks thereafter. Results. Two of the three patients showed mild to moderate improvement of their disease while the third patient did not improve. We can highlight the variability of the results observed in these three patients. Adverse effects were generally mild and well tolerated by the three patients. Despite this, two patients withdrew the therapy due to loss of efficacy in one case and the development of generalized arthalgias in the other case. Conclusions. Treatment of hidradenitis supurativa with infliximab constitutes a moderately useful alternative in some cases

[Kaposi's sarcoma treated with topical alitretinoin]. / Sarcoma de Kaposi clásico tratado con alitretinoína tópica.

Kaposi's sarcoma is a multifocal neoplastic process with four clinical variants, all of them induced by human herpes virus 8. Currently there is no treatment of choice and it depends on the extension and location of the lesions as well as on the clinical type of the disease. Alitretinoin gel 0.1 % is approved for the treatment of cutaneous lesions of AIDS-associated Kaposi's sarcoma. The majority of its side effects appear at the site of application and can lead to therapy withdrawal. We report a case of Kaposi's sarcoma treated with topical alitretinoin that had a favourable evolution in spite of an intense local reaction.

Sarcoma de Kaposi clásico tratado con alitretinoína tópica / Kaposi´s sarcoma treated with topical alitretinoin

El sarcoma de Kaposi es un proceso neoplásico multifocal del cual existen 4 variantes clínicas, todas ellas inducidas por el virus herpes humano tipo 8. En la actualidad no existe un tratamiento de elección y éste depende de la extensión y la localización de las lesiones, así como del tipo clínico de la enfermedad. La alitretinoína al 0,1 % en gel está aprobada para el tratamiento de las lesiones cutáneas del sarcoma de Kaposi asociado a sida. La mayoría de sus efectos secundarios aparecen en el lugar de aplicación y pueden obligar a suspender el tratamiento. Presentamos un caso de sarcoma de Kaposi tratado con alitretinoína tópica con buena evolución pese a la intensa reacción local

Kaposi's sarcoma is a multifocal neoplastic process with four clinical variants, all of them induced by human herpes virus 8. Currently there is no treatment of choice and it depends on the extension and location of the lesions as well as on the clinical type of the disease. Alitretinoin gel 0.1 % is approved for the treatment of cutaneous lesions of AIDS-associated Kaposi's sarcoma. The majority of its side effects appear at the site of application and can lead to therapy withdrawal. We report a case of Kaposi's sarcoma treated with topical alitretinoin that had a favourable evolution in spite of an intense local reaction