THE MECHANISMS CONTRIBUTING TO THE DEVELOPMENT OF ARTERIAL HYPERTENSION, ADVANTAGES AND DISADVANTAGES OF THE ASSOCIATED EXPERIMENTAL MODELS (REVIEW).

Arterial hypertension is one of most common diseases in the world with variable etiologies, yet the exact cause cannot always be found. It is classified as essential (primary) or secondary hypertension. Unlike secondary hypertension, primary hypertension has no known cause. Animal models have been used to investigate the pathophysiology of the disease and for testing new treatment strategies. Using animal models to better understand the etiology, prevention, and treatment of hypertension depends on their accuracy for representing human disease. Current challenges in this field include the development of models mimicking the common hypertensive syndromes and the development of new prevention and treatment strategies. Animal models may be beneficial to address these challenges. While choosing the appropriate model of hypertension, scientists need to choose between small and large animal models. The research scope and objectives, experimental expenses, animal welfare, and practical suitability should all be considered. The advantages and disadvantages of these models need to be assessed in detail in order to select the best model. From the many models of arterial hypertension, it can be distinguish different models of essential and secondary arterial hypertension. Of the essential arterial hypertension three main methods are noteworthy, pharmacological, environmental conditions, and genetic model. As for secondary hypertension, it can be challenged by physical methods such as renal artery clipping or its microembolization.

BIOCHEMICAL ASPECTS OF SYMPTOMATIC TREATMENT IN PATIENTS WITH COVID-19 (REVIEW).

The new Coronavirus has challenged modern medicine. The disease caused by this virus, COVID-19, is characterized by a high rate of lethality, especially in the older age group. There is still no vaccine and no specific treatment, therefore prevention remains the main way to fight the virus. SARS-COV-2 is characterized by high virulence and contagiousness, that's why the main preventive recommendation is social distance. The article reviews the features of this virus, ways of invading the virus in the body, the possible pathogenesis of the disease and the biochemical and pharmacological aspects of symptomatic treatment. The article also discusses the views of various authors, the results of previous studies and sets new perspectives on fighting the virus. The article discusses the mechanism of action of all drugs and the possible impact on the course and outcome of the disease, which has led to differences of opinion among various groups of scientists since the spread of the virus.