[Evaluation of clinical effectiveness of treatment of hepatobiliary disorders in the negative effects of environmental factors in children].

303 children with the diagnosis "Hepatobiliary disorders of cystic duct or gall bladder" and "Sphincter Oddu's spasm" have been examined. After a profound children's examination, the data of objective survey, and also laboratory, biochemical, immune, functional rates (such as ultrasound survey, cardiointervalography) and findings of chemical-analytical survey of the toxics rate (such as aroma carbons, phenol, aldehydes, aliphatic alcohols) in biospheres of children's organisms were a nalysed. The evaluation of the effectiveness of children's hepatobilliary disorders'treatment in conditions of the environmentae negative factors' influence.

[The effects of metacine and anapriline course therapy on the morphofunctional changes in the gastric mucosa of patients with chronic gastroduodenitis].

The article analyzes the influence of course treatment with vegetomodulating preparations on morphofunctional changes in the gastric and duodenal mucosa. Thirty-eight patients with chronic gastroduodenitis dwelling in ecologically unfavorable territories were examined and treated. The study demonstrated positive changes in the histomorphological picture of the gastroduodenal mucosa in children who received conventional standard therapy in combination with the beta-adrenoblocker anaprilin and the M-cholinolytic atropine compared to controls who received only the basic therapy.

[Effects of dicetel on gastrointestinal motility and vegetative dysfunction in patients with duodenal ulcer]. / Vliianie ditsetela na motoriku zheludochno-kishechnogo trakta i vegetativnuiu disfunktsiiu u bol'nykh iazvennoi bolezn'iu dvenadtstiperstnoi kishki.

The great majority of patients with duodenal ulcer (DU) given a single oral dose (50 mg) of dicetel (pinaverium bromide)--a selective blocker of calcium channels--showed optimization of vegetative reactivity and vegetative support of physical and mental activities. This contributes to relief of psychovegetative syndrome of the modulation of dysfunctions of proximal gastrointestinal tract (GIT). The addition of dicetel to combined treatment of PH shortened healing of DU, relieved pain, stopped gastric and intestinal dyspepsia, corrected motor-tonic defects of the proximal GIT caused by dysfunction of different links of the regulatory-adaptive system.

[A status of the adaptational region of the autonomic nervous system in children with chronic gastroduodenitis living under ecologically unfavorable conditions]. / Sostoianie adaptatsionnogo otdela vegetativnoi nervnoi sistemy u detei s khronicheskim gastroduodenitom, prozhivaiushchikh v ékologicheski neblagopriiatnykh usloviiakh.

The authors carry out the analysis of adaptation disorders of a link of vegetative of nervous system at children with chronic gastroduodenitis, living under poor ecological conditions. It is shown, that in these patients the power of vagus connections with vegetal nervous system prevails. In loading test, the inadequacy of adaptation comes to light. The accumulation of Mn and Cr in the blood serum is accompanied by high power of sympathetic connections with vegetal nervous system and accumulation of Ph in the blood serum--by high power of parasympathetic connections with vegetal nervous system.

[Crystallo-optic structures of bile in chronic acalculous cholecystitis]. / Kristalloopticheskie struktury zhelchi pri khronicheskom beskamennom kholetsistite.

A crystal optical study of the cystic bile under the conditions of compulsory dehydration in patients with acalculous cholecystitis made it possible to determine selective markers of lithogenic dyscholia according to the bile oversaturation with cholesterol, bilirubin and calcium. Chronic acalculous cholecystitis (CAC) is a chronic polyetiologic inflammatory disease of the gall-bladder (GB) combined with motor-tonic impairments of the bile-excreting tract function and with changes of physical and chemical properties and biochemical bile structure (dyscholia). CAC contributes to cholestasia, metabolic disorders and formation of calculi. The identification of lithogenic bile properties and early, pre-clinical diagnostics of cholelithiasis remain as urgent as before. Complicated physical and chemical methods are used for diagnostics of cholelithiasis: nuclear magnetic resonance spectroscopy, laser quasielastic scattering, electron microscope studies, gel-distribution chromatography. At present these methods are inaccessible for wide practical application due to their high cost. At the same time it is known that the diagnostics of cholelithiasis at early stages can be based on the detection of liquid crystalline structures in the bile. The object of this study was an early crystal optical diagnostics of dyscholia in patients with CAC and detection of bile lithogenicity markers.

[Psychovegetative changes and their correction in patients with peptide ulcer]. / Izmeneniia psikhovegetativnogo statusa i ego korrektsiia u bol'nykh iazvennoi bolezn'iu.

The study of the psychovegetative status in 106 duodenal ulcer patients discovered alterations in this status. Different treatments were employed, among them--acupuncture with low-frequency alternating magnetic field. The latter had a positive effect on emotional and personality spheres, vegetative regulation, shortened the relief of the basic symptoms, scarring of the ulcer defect.

[Functional effects of pentagastrin and diagnostic possibilities of the pentagastrin test]. / Funktsional'nye éffekty pentagastrina i diagnosticheskie vozmozhnosti pentagastrinovogo testa.

The effect on gastric secretion of a single pentagastrin dose (6 micrograms/kg) against submaximal doses of histamine, euphylline and limontar was studied in 100 healthy subjects aged 20-30. It is shown that pentagastrin test corresponds to maximal histamine test allowing rough measurement of lining cells mass. Normal secretory values and mass of the lining cells have been established as well as normal secretory response of the stomach to submaximal histamine (0.008 mg/kg) and euphylline (7 mg/kg) tests. Diagnostic significance of the pentagastrin test in peptic ulcer and chronic gastritis with secretory insufficiency has been supported. There were some cases of secretory response to euphylline and limontar in pentagastrin-refractory forms of gastric secretion due to mobilization of functional cellular component of the gastric glands. Pentagastrin inhibited initially enhanced gastric evacuation though motor function of the stomach showed no response.

[Chlorozyl, a new Soviet M-cholinolytic agent, and its effectiveness in duodenal ulcer]. / Khlorozil--novyi otechestvennyi M-kholinolitik i ego éffektivnost' pri iazvennoi bolezni dvenadtsatisperstnoi kishki.

The efficacy of a new peripheral M-cholinolytic, chlorozyl, was studied in two representative groups of duodenal ulcer patients and compared with that of atropine sulfate. The effects of single doses of chlorozyl and atropine on gastric acid production and motor function were under study, as was the effect of a course of treatment lasting 24-26 days on clinical symptoms, impaired gastric functions, healing of the ulcer defect, and remote results (in 1-3 years). The findings evidence that chlorozyl drastically inhibited gastric acid production and normalized motor function after a single administration and a course of treatment (in combination with antacids), rapidly alleviated painful and dyspeptic syndromes and provided ulcer cicatrization in 82 percent of patients, reduced the incidence of recurrences twofold within the first year after a course of treatment. Chlorozyl is much superior to atropine in respect of all the parameters listed; side effects are more rare, this being due to the fact that it poorly penetrates the hematoencephalic barrier and its central effect is weaker.

[Experience with objective evaluation of the action of cimetidine--a blocker of histamine-H2 receptors--in patients with peptic ulcer of the duodenum]. / Opyt ob"ektivnoi otsenki deistviia tsimetidina--blokatora H2-retseptorov gistamina--u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

The action of cimetidine, a blocker of H2-histamine receptors, is analysed as compared with the peripheral M-cholinolytics atropine and chlorosyl when administered in single doses and in courses. Study of the drug action on the basic functions of the stomach and on the clinical course of the disease was performed with the aid of the original research methods, mathematic analysis of the pH-grams and electrogastrograms. It was revealed that cimetidine compared very favourably with the peripheral M-cholinolytics as regards the action on acid formation in the stomach, particularly if the drug was applied in single doses, and on the clinical course of the disease, primarily in reference to ulcer cicatrization. However, cimetidine appeared inferior to the cholinolytics in the potency of the inhibitory action on motor function of the stomach both when given in a single dose and in courses.