[Clinical and hygienic substantiation of individual biocorrection for ecologically dependent conditions in the critical groups of the population of Ukrainian industrial areas].

In the article there is considered the problem of pollution of the environment and human body with heavy metals, the effectiveness of individual biocorrection in critical groups of the population--pregnant women and children residing in technologically contaminated areas. In spite of the correspondence of the content of abiotic heavy metals to their MACs in the environment, the concentration of lead and cadmium in the internal environment of the organism in 1,6-15,4 times was found to exceed physiological norms that accompanied by a significant deficiency of essential trace elements. Similar situation has been proved to lead to a reduction in mental health and ability to learn in children, as well as to the various complications in pregnancy. The obtained results served as the scientific substantiation of the feasibility of biocorrection of the trace element imbalance ecological dependent states in the population of the industrial region. The proved high clinical effectiveness of this hygienic biocorrection is a scientific justification for widespread introduction of pectin preparations for health promotion, prevention of ecologically dependent states and increasing the adaptive capacity of the organism.

[Clinical hygienic substantiation for the individual biocorrection of ecologically dependent conditions in the critical population groups industrial areas of Ukraine].

In the article there is considered the problem of environmental and human body pollution with heavy metals, the effectiveness of individual biocorrection in critical population groups--pregnant females and children residing in technologically contaminated areas. It was established that, in spite of the correspondence of the content of abiotic heavy metals to their MACs in the environment, the concentration of lead and cadmium in the internal environment of the organism is 1,6-15,4 times larger than physiological norms and accompanied by substantial deficiency of essential trace elements. The similar situation in children was proved to cause the fall in mental capacity and learning ability, in pregnant females--to various complications. The obtained results were the scientific substantiation for the feasibility of performing of biocorrection for trace elements imbalance and ecologically dependent conditions in the population of the industrial region, proved its high clinical and hygienic efficiency, which is the basis for the wide introduction of pectin containing preparations with the aim to enforce the health, prevent ecologically dependent conditions and increasing the adaptive capacity of the organism.

[Characteristics of selenium status in the population from the industrial region of Ukraine].

The paper presents the results of a study of selenium levels in the blood of apparently healthy residents aged 18 to 59 years in technogenically polluted areas (Dnepropetrovsk, Ukraine). In women, the selenium levels have been ascertained to be 5-13% higher than those in men. The selenium status in the examinees corresponds to an average of the suboptimal level and 16% lower than the optimal one and significantly lower than that in the control area.

[Contribution of heavy metals to the development of reproductive disorders]. / Rol' tiazhelykh metallov v vozniknovenii reproduktivnykh narushenii.

In order to evaluate the role of heavy metals in the reproductive status, a complex hygienic evaluation of total daily entry of lead, cadmium, zinc, and copper in the organism, biomonitoring of metals in indicator biosubstrates, and epidemiological follow-up of the reproductive function were carried out in 6962 healthy women living in industrial cities of the Dnepropetrovsk region. Total daily entry of lead is 0.27 mg, that of cadmium 0.029 mg, which meets the WHO requirements. However the entry of copper and particularly zinc is 1.5-3 times below the physiological norm. Biomonitoring showed high concentrations of lead and cadmium in the body. Regular entry of abiotic metals even in low concentrations in the presence of deficiency of essential metals is fraught with risk of reproductive diseases, which was proven mathematically for all stages of the reproductive function: gestation, labor, and neonatal period.