RESUMO
Molecular dehydration is a polyetiologic hereditary determinatory disease. Variation in the lipid exchange balance resulting in microcirculation disturbance play an important role in the pathogenesis of molecular dehydration. Free radical damages in retina, synthesis activation of nitrogen oxide and cytokines output cause protein synthesis of apoptosis. Disturbances in apoptosis lead to molecular dehydration. Study of pathogenesis links of molecular dehydration gives the possibility to treat this disease.
Assuntos
Degeneração Macular/etiologia , Retina , Vasos Retinianos , Apoptose , Citocinas/metabolismo , Radicais Livres/metabolismo , Humanos , Metabolismo dos Lipídeos , Degeneração Macular/metabolismo , Degeneração Macular/patologia , Degeneração Macular/fisiopatologia , Microcirculação , Óxido Nítrico/biossíntese , Retina/metabolismo , Retina/patologia , Vasos Retinianos/metabolismoRESUMO
The relative content of higher fatty acids (FA) was studied in lachrymal fluid of 10 virtually healthy subjects and of 9 patients with maculodystrophy aged 30 to 40. The FA methyl ethers were assayed with the "Chrystall-2000 M" gas chromatograph. The content of C(15:0), C(15:1), C(16:0) and C(16:1) as well as the content of such oversaturated FA as C(18:3omega6) and C(20:4omega6) was found to be decreased in patients with macoludystrophy. Simultaneously, a higher level of FA with a longer carbon chain (C(17:0), C(18:0), C(18:1), C(18:3omega3) and C(20:3omega6) was registered in these patients. The results testify to changes in the composition of lachrymal fluid in ophthalmopathy and point out the expedience of further research in the discussed field.