RESUMO
We present experience of using anti-thymocytic immunoglobulin (ATG) in complex therapy of patients with extensive secondary peritonitis at the age of 29-83 years. The research was based on 60 patient cases: 29 (48%) of whom were given anti-thymocytic immunoglobulin (ATG) Antilymfolin in post operative period and 31 patient of the control group who did not receive immunomodulating therapy within the complex treatment. The received data clearly demonstrates the effectiveness of anti-thymocytic immunoglobulin (ATG) usage for normalization of innate immunity indices and inflammation reduction. Immunostimulating effect in patients given anti-thymocytic immunoglobulin (ATG) could be seen on the fourth day of the threatment. The drug is equally effective in patients of young and middle age as well as in patients of elderly and senility age. The positive influence of anti-thymocytic immunoglobulin (ATG) on inflammation is shown with the reduction of CRP, gamma-globuline, alpha1-protein fraction serum levels normalization. The use of Antilymfolin induces the regression of inflammation and apparently improves the quality and duration of treatment and rehabilitation.
Assuntos
Soro Antilinfocitário , Sistema Digestório , Sistema Imunitário/efeitos dos fármacos , Inflamação/terapia , Peritonite , Complicações Pós-Operatórias , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Soro Antilinfocitário/administração & dosagem , Soro Antilinfocitário/imunologia , Terapia Combinada , Humanos , Fatores Imunológicos/administração & dosagem , Fatores Imunológicos/imunologia , Imunomodulação , Inflamação/imunologia , Pessoa de Meia-Idade , Monitorização Imunológica , Peritonite/etiologia , Peritonite/imunologia , Peritonite/terapia , Ruptura Espontânea/complicações , Resultado do TratamentoRESUMO
Results of Antilympholin-K3 use in combined treatment of purulent-inflammatory complications in polytrauma, diabetes, infected pancreonecrosis are analysed. Thirty-nine patients aged from 19 to 74 years were treated. Double injection of Antilympholin-K3 enhanced phagocytic activity of neutrophils, phagocytic index, chemiluminescence of mononuclears and neutrophils, immunoglobulins concentration. Positive dynamics in immunological indices is accompanied by improving clinical status, cleaning of postoperative wounds from pus, improving of epithelisation.
Assuntos
Soro Antilinfocitário/uso terapêutico , Complicações do Diabetes , Imunoglobulinas/uso terapêutico , Imunossupressores/uso terapêutico , Inflamação/tratamento farmacológico , Traumatismo Múltiplo/complicações , Pancreatopatias/complicações , Adulto , Idoso , Animais , Feminino , Cabras , Humanos , Inflamação/etiologia , Inflamação/cirurgia , Masculino , Pessoa de Meia-Idade , Necrose , Pancreatopatias/patologia , Resultado do TratamentoAssuntos
Proteínas de Fase Aguda/metabolismo , Citocinas/sangue , Rejeição de Enxerto/imunologia , Imunossupressores/uso terapêutico , Transplante de Rim/fisiologia , Proteínas de Fase Aguda/análise , Soro Antilinfocitário/uso terapêutico , Azatioprina/uso terapêutico , Ciclosporina/uso terapêutico , Humanos , Terapia de Imunossupressão , Transplante de Rim/imunologia , Metilprednisolona/uso terapêutico , Prednisolona/uso terapêutico , Valores de ReferênciaRESUMO
The main parameters of hemodynamics and oxygen regimen were investigated in isolated rat heart (130 tests) during its perfusion with red blood cells preserved in glugicir (GGC) and citroglucophosphate (CGP). Short-term storage red blood cells did not show disorders in O2 transport to tissues. Long-term storage red blood cells (both in GGC and CGP) showed disorders in hemodynamics that were associated with appearance of free hemoglobin in the perfusion medium due to disruption of some red blood cells by the perfusion apparatus.