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1.
J Comp Pathol ; 176: 122-127, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32359624

RESUMO

We report the pathological features of a facial squamous cell carcinoma (SCC) and an abdominal peripheral nerve sheath tumour (PNST) with rhabdomyoblastic differentiation in an aged free-ranging rough-toothed dolphin (Steno bredanensis). The animal was found stranded dead in poor body condition. On external examination, there was a 25 × 7 × 3 cm extensively ulcerated area on the right maxillary region of the rostrum, involving the oral mucocutaneous junction with prominent nodular edges, severe soft tissue loss and extensive maxillary and premaxillary bone lysis. On abdominal dissection, a 5 × 4 × 3.5 cm pale tan to red, raised mass expanded the inner aspect of the right transverse abdominis muscle. Microscopically, the aggressive facial lesion was an acantholytic SCC with extensive osteolysis; there was no evidence of metastasis in the tissues examined. The abdominal mass had cytohistomorphological features compatible with a localized PNST, including whorling, Antoni A and Antoni B areas and Verocay bodies intermixed with rhabdomyoblastic components, as suggested by phosphotungstic acid haematoxylin stain. This neoplasm was locally infiltrative, yet no metastases were observed in the tissues examined. No immunohistochemical investigations could be performed due to lack of tissue availability. Total DNA from the formalin-fixed and paraffin wax-embedded SCC was extracted and tested by polymerase chain reaction for herpesvirus and papillomavirus genetic material. There was no amplification for either of these genera. Other pathological findings observed in this animal were related to the 'live-stranding stress response'. The severity and extent of the facial SCC likely related to anorexia and poor body condition and might have played a role in the stranding and death of this dolphin. These two tumour subtypes add to the relatively uncommon reports of neoplasia in cetaceans. Specifically, these appear to be the first neoplasia records for rough-toothed dolphins, including the first documentation of a PNST with features compatible with rhabdomyoblastic differentiation in a marine mammal.


Assuntos
Neoplasias Abdominais/veterinária , Carcinoma de Células Escamosas/veterinária , Golfinhos , Neoplasias Faciais/veterinária , Neoplasias de Bainha Neural/veterinária , Animais
2.
Nutr Hosp ; 27(5): 1391-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23478683

RESUMO

INTRODUCTION: In many countries, the prevalence of obesity and chronic diseases has been increased, which are normally associated with changes in lifestyle, that are especially characterized by high consumption of diets rich in carbohydrates of rapid absorption. Such diets classified as high glycemic index and high glycemic load can lead to hyperglycemia. OBJECTIVES: Discuss the role of the diets of high glycemic index and/or high glycemic load on the oxidative stress and inflammatory process, in order to verify their influence on those diseases. RESULTS AND DISCUSSION: Studies demonstrate direct relationship between hyperglycemia, inflammatory process and oxidative stress that contribute to the development of chronic diseases.


Assuntos
Hiperglicemia/complicações , Hiperglicemia/patologia , Inflamação/etiologia , Inflamação/patologia , Estresse Oxidativo/fisiologia , Doença Crônica , Dieta , Índice Glicêmico , Humanos , Obesidade/complicações
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