1.
J Org Chem
; 86(20): 14232-14237, 2021 10 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34596412
RESUMO
Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.
Assuntos
Amidas , Ésteres , Dipeptídeos
2.
Org Biomol Chem
; 9(18): 6271-7, 2011 Sep 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21773620
RESUMO
The generation of azomethine ylides from the readily accessible hemiaminals 3 and 8 or from iminium salt 10 was studied. Compounds 8 gave anti- and syn-cycloadducts containing the quinocarcin core through a catalyst-free dehydration process.