Liver Cirrhosis: The Immunocompromised State.

Systemic inflammation and immunodeficiency are important components of cirrhosis-associated immune dysfunction (CAID), the severity of which is dynamic, progressive, and associated with the greater deterioration of liver function. Two inflammation phenotypes have been described: low-grade and high-grade systemic inflammation. Both of these phenotypes are related to liver cirrhosis function; thus, high-grade inflammation is correlated with the severity of hepatic insufficiency, bacterial translocation, and organic insufficiency, with which the risk of infections increases and the prognosis worsens. Bacterial translocation (BT) plays a relevant role in persistent systemic inflammation in patients with cirrhosis, and the prophylactic employment of antibiotics is useful for reducing events of infection and mortality.

Bathymetric origin shapes the physiological responses of Pterygophora californica (Laminariales, Phaeophyceae) to deep marine heatwaves.

Kelp communities are experiencing exacerbated heat-related impacts from more intense, frequent, and deeper marine heatwaves (MHWs), imperiling the long-term survival of kelp forests in the climate change scenario. The occurrence of deep thermal anomalies is of critical importance, as elevated temperatures can impact kelp populations across their entire bathymetric range. This study evaluates the impact of MHWs on mature sporophytes of Pterygophora californica (walking kelp) from the bathymetric extremes (8-10 vs. 25-27 m) of a population situated in Baja California (Mexico). The location is near the southernmost point of the species's broad distribution (from Alaska to Mexico). The study investigated the ecophysiological responses (e.g., photobiology, nitrate uptake, oxidative stress) and growth of adult sporophytes through a two-phase experiment: warming simulating a MHW and a post-MHW phase without warming. Generally, the effects of warming differed depending on the bathymetric origin of the sporophytes. The MHW facilitated essential metabolic functions of deep-water sporophytes, including photosynthesis, and promoted their growth. In contrast, shallow-water sporophytes displayed metabolic stress, reduced growth, and oxidative damage. Upon the cessation of warming, certain responses, such as a decline in nitrate uptake and net productivity, became evident in shallow-water sporophytes, implying a delay in heat-stress response. This indicates that variation in temperatures can result in more prominent effects than warming alone. The greater heat tolerance of sporophytes in deeper waters shows convincing evidence that deep portions of P. californica populations have the potential to serve as refuges from the harmful impacts of MHWs on shallow reefs.

Protection of hybrid immunity against SARS-CoV-2 reinfection and severe COVID-19 during periods of Omicron variant predominance in Mexico.

Background: With the widespread transmission of the Omicron SARS-CoV-2 variant, reinfections have become increasingly common. Here, we explored the role of immunity, primary infection severity, and variant predominance in the risk of reinfection and severe COVID-19 during Omicron predominance in Mexico. Methods: We analyzed reinfections in Mexico in individuals with a primary infection separated by at least 90 days from reinfection using a national surveillance registry of SARS-CoV-2 cases from March 3rd, 2020, to August 13th, 2022. Immunity-generating events included primary infection, partial or complete vaccination, and booster vaccines. Reinfections were matched by age and sex with controls with primary SARS-CoV-2 infection and negative RT-PCR or antigen test at least 90 days after primary infection to explore reinfection and severe disease risk factors. We also compared the protective efficacy of heterologous and homologous vaccine boosters against reinfection. Results: We detected 231,202 SARS-CoV-2 reinfections in Mexico, most occurring in unvaccinated individuals (41.55%). Over 207,623 reinfections occurred during periods of Omicron (89.8%), BA.1 (36.74%), and BA.5 (33.67%) subvariant predominance and a case-fatality rate of 0.22%. Vaccination protected against reinfection, without significant influence of the order of immunity-generating events and provided >90% protection against severe reinfections. Heterologous booster schedules were associated with ~11% and ~ 54% lower risk for reinfection and reinfection-associated severe COVID-19, respectively, modified by time-elapsed since the last immunity-generating event, when compared against complete primary schedules. Conclusion: SARS-CoV-2 reinfections increased during Omicron predominance. Hybrid immunity provides protection against reinfection and associated severe COVID-19, with potential benefit from heterologous booster schedules.

Shading by giant kelp canopy can restrict the invasiveness of Undaria pinnatifida (Laminariales, Phaeophyceae).

The spread of non-indigenous and invasive seaweeds has increased worldwide, and their potential effects on native seaweeds have raised concern. Undaria pinnatifida is considered among the most prolific non-indigenous species. This species has expanded rapidly in the Northeast Pacific, overlapping with native communities such as the iconic giant kelp forests (Macrocystis pyrifera). Canopy shading by giant kelp has been argued to be a limiting factor for the presence of U. pinnatifida in the understory, thus its invasiveness capacity. However, its physiological plasticity under light limitation remains unclear. In this work, we compared the physiology and growth of juvenile U. pinnatifida and M. pyrifera sporophytes transplanted to the understory of a giant kelp forest, to juveniles growing outside of the forest. Extreme low light availability compared to that outside (~0.2 and ~4.4 mol photon ⋅ m-2 ⋅ d-1 , respectively) likely caused a "metabolic energy crisis" in U. pinnatifida, thus restricting its photoacclimation plasticity and nitrogen acquisition, ultimately reducing its growth. Despite M. pyrifera juveniles showing photoacclimatory responses (e.g., increases in photosynthetic efficiency and lower compensation irradiance, Ec ), their physiological/vegetative status deteriorated similarly to U. pinnatifida, which explains the low recruitment inside the forest. Generally, our results revealed the ecophysiological basis behind the limited growth and survival of juvenile U. pinnatifida sporophytes in the understory.

Effectiveness of a nationwide COVID-19 vaccination program in Mexico against symptomatic COVID-19, hospitalizations, and death: a retrospective analysis of national surveillance data.

OBJECTIVES: Vaccination has been effective in ameliorating the impact of COVID-19. Here, we report vaccine effectiveness (VE) of the nationally available COVID-19 vaccines in Mexico. METHODS: Retrospective analysis of a COVID-19 surveillance system to assess the VE of the BNT162b2, messenger RNA (mRNA)-12732, Gam-COVID-Vac, Ad5-nCoV, Ad26.COV2.S, ChAdOx1, and CoronaVac vaccines against SARS-CoV-2 infection, COVID-19 hospitalization, and death in Mexico. The VE was estimated using time-varying Cox proportional hazard models in vaccinated and unvaccinated adults, adjusted for age, sex, and comorbidities. VE was also estimated for adults with diabetes, aged ≥60 years, and comparing the predominance of SARS-CoV-2 variants B.1.1.519 and B.1.617.2. RESULTS: We assessed 793,487 vaccinated and 4,792,338 unvaccinated adults between December 24, 2020 and September 27, 2021. The VE against SARS-CoV-2 infection was the highest for fully vaccinated individuals with mRNA-12732 (91.5%, 95% confidence interval [CI] 90.3-92.4) and Ad26.COV2.S (82.2%, 95% CI 81.4-82.9); for COVID-19 hospitalization, BNT162b2 (84.3%, 95% CI 83.6-84.9) and Gam-COVID-Vac (81.4% 95% CI 79.5-83.1), and for mortality, BNT162b2 (89.8%, 95% CI 89.2-90.2) and mRNA-12732 (93.5%, 95% CI 86.0-97.0). The VE decreased for all vaccines in adults aged ≥60 years, people with diabetes, and periods of Delta variant predominance. CONCLUSION: All the vaccines implemented in Mexico were effective against SARS-CoV-2 infection, COVID-19 hospitalization, and death. Mass vaccination with multiple vaccines is useful to maximize vaccination coverage.

Investigation of the DNA Damage and Oxidative Effect Induced by Venlafaxine in Mouse Brain and Liver Cells.

Venlafaxine is an antidepressant used worldwide. Therefore, studies to confirm its safe use are mandatory. This report evaluated the drug DNA damage capacity in the brain and liver of ICR mice, and its oxidative effect on DNA, lipids, and proteins, as well as the amount of nitrites, also in the brain and liver. Determinations were made at 2, 6, 12, and 24 h post-treatment, excluding DNA oxidation that was observed at 2 h. The tested doses of venlafaxine were 5, 50, and 250 mg/kg. The results showed DNA damage in the brain with the two more elevated doses of venlafaxine at 2 and 6 h post-treatment and also at 12 h in the liver. The comet assay plus the FPG enzyme showed DNA damage in both organs with all doses. The two high doses increased lipoperoxidation in the two tissues from 6 to 12 h post-administration. Protein oxidation increased with the three doses, mainly from 2 to 12 h, and nitrite content was elevated only with the high dose in the liver. The drug was found to affect both tissues, although it was more pronounced in the liver. Interestingly, DNA oxidative damage was observed even with a dose that corresponds to the therapeutic range. The clinical relevance of these findings awaits further investigations.

Treatment of Intracranial Tumors With Stereotactic Radiosurgery: Short-Term Results From Cuba.

Background Although international publications on radiosurgery have increased exponentially, reports of heterogeneous series treated with linear accelerator (LINAC) are scarce. Since most intracranial tumors are irregular in size and not spherical, LINACs (Elekta Precise®, Elekta AB, Sweden), fitted with a multi-leaf collimator, allow for precise stereotactic radiosurgery for the entire tumor. Aim To evaluate the effects of LINAC on an outpatient basis with patients diagnosed with various intracranial malignancies. Methodology A retrospective observational study of a series of cases of patients with intracranial lesions treated at the Institute of Oncology and Radiobiology using LINAC was carried out from October 2019 to May 2021 to evaluate the therapeutic results of radiosurgery in patients with intracranial tumors. Results A total of 22 lesions in 20 patients were treated with LINAC. The average age of the patients was 49.7, and the male-female ratio was 1:2. The cases consisted were mostly vestibular schwannoma (7 lesions), metastases from breast cancer (3 lesions), and tuberculum sellae meningioma (2 lesions). The prescription dose covered 99% of the planning target volume in 16 lesions (72.7%) and 100% in six lesions (27.3%) (prescription volume). In meningiomas and schwannomas, doses between 12 and 14 Gy were used, in plasmacytoma 13 Gy, in pilocytic astrocytoma 14 Gy, in cavernoma 15 Gy, in breast cancer metastasis between 18 and 20 Gy, and in lung cancer metastasis 22 Gy. When evaluating local control, 11 patients exhibited stable findings at the six-month control while 10 had partial regression, and a single patient had total regression. Minor complications such as perilesional edema, facial paresthesia, facial paralysis, and transient alopecia were observed in eight of the patients. Conclusions Patients with extra-axial, low-grade malignancy, and posterior fossa lesions were predominant in the studied population. Radiosurgery treatment is associated with good local control of the treated lesions. Complications are infrequent, mild, and predominated by perilesional edema.

Development of a Nanostructured Electrochemical Genosensor for the Detection of the K-ras Gene.

In the scientific literature, it has been documented that electrochemical genosensors are novel analytical tools with proven clinical diagnostic potential for the identification of carcinogenic processes due to genetic and epigenetic alterations, as well as infectious diseases due to viruses or bacteria. In the present work, we describe the construction of an electrochemical genosensor for the identification of the k12p.1 mutation; it was based on use of Screen-Printed Gold Electrode (SPGE), Cyclic Voltammetry (CV), and Atomic Force Microscopy (AFM), for the monitoring the electron transfer trough the functionalized nanostructured surface and corresponding morphological changes. The sensitivity of the genosensor showed a linear response for the identification of the k12p.1 mutation of the K-ras gene in the concentration range of 10 fM to 1 µM with a detection limit of 7.96 fM in the presence of doxorubicin (Dox) as DNA intercalating agent and indicator of the hybridization reaction. Thus, the electrochemical genosensor developed could be useful for the identification of diseases related with the K-ras oncogene.

The Effects of COVID-19 on Healthcare Workers and Non-Healthcare Workers in Mexico: 14 Months into the Pandemic.

Background and Objectives: Healthcare workers (HCWs) play important roles in mitigating the COVID-19 pandemic and are more likely to become infected with COVID-19. Mexico, among other countries, had a high incidence and prevalence of cases and deaths from this disease. Material and Methods: This retrospective study evaluated the clinical characteristics as well as the geographical distribution of cases, deaths, and active cases of COVID-19 in HCWs and non-HCWs using official information from the Ministry of Health of Mexico. Results: A total of 235,343 cases of COVID-19 were reported in healthcare workers, and 2,094,191 cases were reported in non-healthcare workers. A total of 76.0% of cases in healthcare workers occurred in those who were between 25 and 50 years of age, and 71.4% of deaths occurred in those who were 50 to 69 years of age. Among healthcare workers, the most frequent comorbidities were obesity (15.2%), hypertension (10.9%), and diabetes (6.8%). Nurses were the group with the most cases (39.7%), followed by other healthcare workers (30.6%), physicians (26%), and dentists (1.6%). Physicians were the group with the most deaths (46%), followed by other professionals (30%), nurses (19%), and dentists (3%). Conclusion: These findings are likely the result of healthcare workers in Mexico being at a greater risk of exposure to SARS-CoV-2.

Growth Patterns in Seedling Roots of the Pincushion Cactus Mammillaria Reveal Trends of Intra- and Inter-Specific Variation.

Genetic mechanisms controlling root development are well-understood in plant model species, and emerging frontier research is currently dissecting how some of these mechanisms control root development in cacti. Here we show the patterns of root architecture development in a gradient of divergent lineages, from populations to species in Mammillaria. First, we show the patterns of variation in natural variants of the species Mammillaria haageana. Then we compare this variation to closely related species within the Series Supertexta in Mammillaria (diverging for the last 2.1 million years) in which M. haageana is inserted. Finally, we compared these patterns of variation to what is found in a set of Mammillaria species belonging to different Series (diverging for the last 8 million years). When plants were grown in controlled environments, we found that the variation in root architecture observed at the intra-specific level, partially recapitulates the variation observed at the inter-specific level. These phenotypic outcomes at different evolutionary time-scales can be interpreted as macroevolution being the cumulative outcome of microevolutionary phenotypic divergence, such as the one observed in Mammillaria accessions and species.

Garlic (Allium sativum L.): A Brief Review of Its Antigenotoxic Effects.

Traditional Medicine/Complementary and Alternative Medicine is a practice that incorporates medicine based on plants, animals, and minerals for diagnosing, treating, and preventing certain diseases, including chronic degenerative diseases such as obesity, diabetes, hypertension, atherosclerosis, and cancer. Different factors generate its continued acceptance, highlighting its diversity, easy access, low cost, and the presence of relatively few adverse effects and, importantly, a high possibility of discovering antigenotoxic agents. In this regard, it is known that the use of different antigenotoxic agents is an efficient alternative to preventing human cancer and that, in general, these can act by means of a combination of various mechanisms of action and against one or various mutagens and/or carcinogens. Therefore, it is relevant to confirm its usefulness, efficacy, and its spectrum of action through different assays. With this in mind, the present manuscript has as its objective the compilation of different investigations carried out with garlic that have demonstrated its genoprotective capacity, and that have been evaluated by means of five of the most outstanding tests (Ames test, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay). Thus, we intend to provide information and bibliographic support to investigators in order for them to broaden their studies on the antigenotoxic spectrum of action of this perennial plant.

Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model.

Geranium schiedeanum has been used in traditional therapies as an antiseptic, antipyretic, and as analgesic. The present study was designed to evaluate the pretreatment with G. schiedeanum total extract (GS) and its active metabolites on stimulating the endogenous antioxidant defense system (EADS): catalase (Cat), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione reduction index (RI GSH/GSSG) in rat liver treated with a sublethal dose (6.6 mmol/Kg) of thioacetamide (TAA) in order to probe the capacity of GS and the active compounds to reduce liver injury. This was assessed by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (BILT) in rats pretreated or not with TAA, and pretreated or not with GS and its metabolites. The results showed that GS was able to induce the production of EADS enzymes, increasing redox index GSH/GSSG at 24 and 48 h after intoxication, and both the extract and the ellagic acid exhibited a significant reduction of hepatic damage markers. Our data confirmed the hepatoprotective effect of GS and its metabolites, like ellagic acid, support the possible use of this extract in the treatment of liver injury.

Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin.

Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.

Colocación de un dispositivo de derivación porto sistémica en el tratamiento del paciente con hipertensión portal / Transjugular intrahepatic portosystemic shunt in the management of portal hypertension

El shunt portosistémico intrahepático transyugular es un tratamiento aceptado y efectivo para el manejo de las complicaciones de la hipertensión portal en el paciente con cirrosis hepática. La colocación de este shunt es una técnica segura que mejora la calidad de vida de estos pacientes y de aquellos con ascitis refractaria o sangrados gastrointestinales por varices esofágicas. Esta técnica surgió hace más de 20 años, aun así, no existen publicaciones en la literatura médica sobre la implementación de este proceder en Cuba. Se describe la colocación de un stent-graft portosistémico recubierto tipo Viatorr realizada en el 2015 en un paciente masculino de 52 años de edad que debuta con un cuadro de sangrado digestivo alto como consecuencia de una cirrosis enólica diagnosticada 6 años antes. El proceder se llevó a cabo sin complicaciones inmediatas y con una reducción instantánea de la presión portal de 24 a 12 por ciento. Podemos señalar que el proceso de implantación del shunt portosistémico intrahepático transyugular es técnicamente realizable por el radiólogo intervencionista. Los resultados dependerán en gran medida de la experiencia del operador. Este proceder que gana cada día más confiabilidad entre los médicos y los pacientes, por su alta tasa de éxito y capacidad resolutiva, puede ser implementado en Cuba de manera sistemática y, a partir de esta experiencia inicial, generalizar su proceder a otros centros hospitalarios del país para beneficio de los pacientes(AU)

Transjugular intrahepatic portosystemic shunt is an effective accepted treatment in the management of portal hypertension complications in a hepatic cirrhosis patient. Transjugular intrahepatic portosystemic shunt placement is a safe technique that improves the quality of life of these patients and of those suffering from refractory ascites and gastrointestinal bleedings. This procedure emerged over 20 years ago; however no reports on Cuban literature about the implementation of this technique are found. This article described the placement of a covered portosystemic stent graft performed in a 52 years-old male patient who presented with upper digestive bleeding resulting from enolic cirrhosis diagnosed 6 years before. The procedure was performed with no immediate complicatios and instant reduction of portal pressure from 24 to 12 percent. We consider that the transjugular intrahepatic portosystemic shunt could be technically placed by the interventionist radiologist. The results will depend to a great extent on the experience of the staff. This procedure, which gains more reliability among physicians and patients because of its high rate of success and resolute capacity, may be implemented in Cuba on a systematic basis. Taking this initial experience as a starting point, the procedure may be extended to other hospitals in the country for the benefit of the patients(AU)

Colocación de un dispositivo de derivación porto sistémica en el tratamiento del paciente con hipertensión portal / Transjugular intrahepatic portosystemic shunt in the management of portal hypertension

El shunt portosistémico intrahepático transyugular es un tratamiento aceptado y efectivo para el manejo de las complicaciones de la hipertensión portal en el paciente con cirrosis hepática. La colocación de este shunt es una técnica segura que mejora la calidad de vida de estos pacientes y de aquellos con ascitis refractaria o sangrados gastrointestinales por varices esofágicas. Esta técnica surgió hace más de 20 años, aun así, no existen publicaciones en la literatura médica sobre la implementación de este proceder en Cuba. Se describe la colocación de un stent-graft portosistémico recubierto tipo Viatorr realizada en el 2015 en un paciente masculino de 52 años de edad que debuta con un cuadro de sangrado digestivo alto como consecuencia de una cirrosis enólica diagnosticada 6 años antes. El proceder se llevó a cabo sin complicaciones inmediatas y con una reducción instantánea de la presión portal de 24 a 12 por ciento. Podemos señalar que el proceso de implantación del shunt portosistémico intrahepático transyugular es técnicamente realizable por el radiólogo intervencionista. Los resultados dependerán en gran medida de la experiencia del operador. Este proceder que gana cada día más confiabilidad entre los médicos y los pacientes, por su alta tasa de éxito y capacidad resolutiva, puede ser implementado en Cuba de manera sistemática y, a partir de esta experiencia inicial, generalizar su proceder a otros centros hospitalarios del país para beneficio de los pacientes(AU)

Transjugular intrahepatic portosystemic shunt is an effective accepted treatment in the management of portal hypertension complications in a hepatic cirrhosis patient. Transjugular intrahepatic portosystemic shunt placement is a safe technique that improves the quality of life of these patients and of those suffering from refractory ascites and gastrointestinal bleedings. This procedure emerged over 20 years ago; however no reports on Cuban literature about the implementation of this technique are found. This article described the placement of a covered portosystemic stent graft performed in a 52 years-old male patient who presented with upper digestive bleeding resulting from enolic cirrhosis diagnosed 6 years before. The procedure was performed with no immediate complicatios and instant reduction of portal pressure from 24 to 12 percent. We consider that the transjugular intrahepatic portosystemic shunt could be technically placed by the interventionist radiologist. The results will depend to a great extent on the experience of the staff. This procedure, which gains more reliability among physicians and patients because of its high rate of success and resolute capacity, may be implemented in Cuba on a systematic basis. Taking this initial experience as a starting point, the procedure may be extended to other hospitals in the country for the benefit of the patients(AU)

Land use changes after the period commodities rising price in the Rio Grande do Sul State, Brazil / Mudanças no uso da terra depois do período de aumento de preço das commodities no Rio Grande do Sul, Brasil

At the end of the 20th and early 21st century, agricultural systems incorporated definitively a new mission: to generate goods for a world population that continues to grow and whose way of life demand food with low environmental impact. Soybean is the main raw material for the production of biodiesel in Brazil, accountably responsible for 82.4% of the total produced between 2006 and 2013. The Brazilian state of Rio Grande do Sul (RS), which is formed by the Pampa and the Atlantic forest biomes, was responsible for 35.7% of the countrys biodiesel production in the referred period. The aim of this paper was to verify the impact of the increased area of soybean cultivation in land use in Rio Grande do Sul State, in the period between 1990 and 2015, considering separately its two biomes (Pampa and Atlantic Forest) original areas, using both census dataset and satellite images. We used the period from 1990 to 2000 as before commodity rising price (BCRP) and the period from 2000 to 2013 as commodity rising price (CRP). The 505,162 ha from Atlantic Forest biome and 1,192,115ha from Pampa biome were added to soybean production in the CRP period. In the Atlantic Forest, this enlargement occurred in the border of the main production area, while in Pampa biome conversion of natural grassland to crop land was the main reason for the large increment in the cultivated area.(AU)

No final do século XX e início do século XXI, os sistemas agrícolas incorporaram definitivamente uma nova missão: gerar energia para uma população mundial que continua a crescer e que demanda por seu modo de vida, não só alimentos, mas também, cada vez mais energia, principalmente, energia com baixo impacto ambiental. A soja permaneceu a principal matéria-prima para a produção de biodiesel no Brasil, no período de 2006 a 2013, em que foi responsável por 82,4%, sendo o estado do RS responsável por 35,7% do total da produção brasileira de biodiesel. O objetivo deste trabalho é verificar o impacto do aumento da área de cultivo de soja no uso da terra no Rio Grande do Sul, no período entre 1990 e 2015. Considera-se, separadamente, as áreas originais de seus dois biomas (Pampa e Mata Atlântica), usando o conjunto de dados do IBGE e imagens de satélite. Utilizou-se o período de 1990 a 2000 como o período anterior ao da suba de preços de commodities (BCRP) e, o período de 2000 a 2013 como período de aumento do preço das commodities (CRP). Um total de 505.162ha do bioma Mata Atlântica e de 1.192.115ha do bioma Pampa foram incorporados à produção de soja no período CRP. No bioma Mata Atlântica, o aumento ocorreu nos limites da área cultivada, enquanto que no bioma Pampa através da conversão da área com pastagem nativa.(AU)

Land use changes after the period commodities rising price in the Rio Grande do Sul State, Brazil / Mudanças no uso da terra depois do período de aumento de preço das commodities no Rio Grande do Sul, Brasil

At the end of the 20th and early 21st century, agricultural systems incorporated definitively a new mission: to generate goods for a world population that continues to grow and whose way of life demand food with low environmental impact. Soybean is the main raw material for the production of biodiesel in Brazil, accountably responsible for 82.4% of the total produced between 2006 and 2013. The Brazilian state of Rio Grande do Sul (RS), which is formed by the Pampa and the Atlantic forest biomes, was responsible for 35.7% of the countrys biodiesel production in the referred period. The aim of this paper was to verify the impact of the increased area of soybean cultivation in land use in Rio Grande do Sul State, in the period between 1990 and 2015, considering separately its two biomes (Pampa and Atlantic Forest) original areas, using both census dataset and satellite images. We used the period from 1990 to 2000 as before commodity rising price (BCRP) and the period from 2000 to 2013 as commodity rising price (CRP). The 505,162 ha from Atlantic Forest biome and 1,192,115ha from Pampa biome were added to soybean production in the CRP period. In the Atlantic Forest, this enlargement occurred in the border of the main production area, while in Pampa biome conversion of natural grassland to crop land was the main reason for the large increment in the cultivated area.

No final do século XX e início do século XXI, os sistemas agrícolas incorporaram definitivamente uma nova missão: gerar energia para uma população mundial que continua a crescer e que demanda por seu modo de vida, não só alimentos, mas também, cada vez mais energia, principalmente, energia com baixo impacto ambiental. A soja permaneceu a principal matéria-prima para a produção de biodiesel no Brasil, no período de 2006 a 2013, em que foi responsável por 82,4%, sendo o estado do RS responsável por 35,7% do total da produção brasileira de biodiesel. O objetivo deste trabalho é verificar o impacto do aumento da área de cultivo de soja no uso da terra no Rio Grande do Sul, no período entre 1990 e 2015. Considera-se, separadamente, as áreas originais de seus dois biomas (Pampa e Mata Atlântica), usando o conjunto de dados do IBGE e imagens de satélite. Utilizou-se o período de 1990 a 2000 como o período anterior ao da suba de preços de commodities (BCRP) e, o período de 2000 a 2013 como período de aumento do preço das commodities (CRP). Um total de 505.162ha do bioma Mata Atlântica e de 1.192.115ha do bioma Pampa foram incorporados à produção de soja no período CRP. No bioma Mata Atlântica, o aumento ocorreu nos limites da área cultivada, enquanto que no bioma Pampa através da conversão da área com pastagem nativa.

Epilepsia / Epilepsy

El objetivo central de este apertado es el estudio sociodemográfico de la población con diagnóstico de epilepsia y el análisis de las prácticas clínicas realizadas en el Manicomio General. Nos ineressa examinar las características sociales de los pacientes así como las respuestas terapéuticas en torno al problema de las convulsiones.(AU)

Land use changes after the period commodities rising price in the Rio Grande do Sul State, Brazil / Mudanças no uso da terra depois do período de aumento de preço das commodities no Rio Grande do Sul, Brasil

ABSTRACT: At the end of the 20th and early 21st century, agricultural systems incorporated definitively a new mission: to generate goods for a world population that continues to grow and whose way of life demand food with low environmental impact. Soybean is the main raw material for the production of biodiesel in Brazil, accountably responsible for 82.4% of the total produced between 2006 and 2013. The Brazilian state of Rio Grande do Sul (RS), which is formed by the Pampa and the Atlantic forest biomes, was responsible for 35.7% of the country's biodiesel production in the referred period. The aim of this paper was to verify the impact of the increased area of soybean cultivation in land use in Rio Grande do Sul State, in the period between 1990 and 2015, considering separately its two biomes (Pampa and Atlantic Forest) original areas, using both census dataset and satellite images. We used the period from 1990 to 2000 as before commodity rising price (BCRP) and the period from 2000 to 2013 as commodity rising price (CRP). The 505,162 ha from Atlantic Forest biome and 1,192,115ha from Pampa biome were added to soybean production in the CRP period. In the Atlantic Forest, this enlargement occurred in the border of the main production area, while in Pampa biome conversion of natural grassland to crop land was the main reason for the large increment in the cultivated area.

RESUMO: No final do século XX e início do século XXI, os sistemas agrícolas incorporaram definitivamente uma nova missão: gerar energia para uma população mundial que continua a crescer e que demanda por seu modo de vida, não só alimentos, mas também, cada vez mais energia, principalmente, energia com baixo impacto ambiental. A soja permaneceu a principal matéria-prima para a produção de biodiesel no Brasil, no período de 2006 a 2013, em que foi responsável por 82,4%, sendo o estado do RS responsável por 35,7% do total da produção brasileira de biodiesel. O objetivo deste trabalho é verificar o impacto do aumento da área de cultivo de soja no uso da terra no Rio Grande do Sul, no período entre 1990 e 2015. Considera-se, separadamente, as áreas originais de seus dois biomas (Pampa e Mata Atlântica), usando o conjunto de dados do IBGE e imagens de satélite. Utilizou-se o período de 1990 a 2000 como o período anterior ao da suba de preços de commodities (BCRP) e, o período de 2000 a 2013 como período de aumento do preço das commodities (CRP). Um total de 505.162ha do bioma Mata Atlântica e de 1.192.115ha do bioma Pampa foram incorporados à produção de soja no período CRP. No bioma Mata Atlântica, o aumento ocorreu nos limites da área cultivada, enquanto que no bioma Pampa através da conversão da área com pastagem nativa.