RESUMO
INTRODUCTION AND OBJECTIVES: Coronary artery disease has been related to infection by Chlamydia pneumoniae even only in a few studies the association between presence of antibodies to this microorganism and the prognosis of patients with ischemic heart disease has been assessed. The objective of our study was to assess the impact of positivity of anti-Chlamydia pneumoniae antibodies in the morbidity and mortality associated to ischemic heart disease. METHODS: 249 patients with ischemic cardiopathy were evaluated (97 with myocardial infarction, 83 with unstable angina and 69 with stable angina), recluted along 1 year and with 3-year follow-up. IgG anti-Chlamydia pneumoniae antibodies were measured with microimmunofluorescence. The cut off point considered for positive serology was set in 1/64. RESULTS: In the group of 97 patients with acute myocardial infarction, 43% showed positive titers of IgG antibody to C. pneumoniae. We observed a statistically significant association (p = 0.007) between positive serology and higher survival of acute myocardial infarction patients. A logistic regression was carried out with mortality, age, and serology as variables; age was the only variable that explained mortality (p = 0.0012), and the serology lost its statistical meaning. In the groups of 83 patients with unstable angina and of 69 patients with stable angina, 42% and 58%, respectively, showed positive serology for C. pneumoniae. We did not find a statistically significant association in both groups between positive serology to C. pneumoniae and the prognostic factors related to morbidity and mortality (rehospitalization and mortality). CONCLUSIONS: The presence of IgG antibodies to C. pneumoniae is not a marker of morbidity and mortality in our population of patients with ischemic heart disease.
Assuntos
Infecções por Chlamydia/imunologia , Chlamydophila pneumoniae/imunologia , Imunoglobulina G/imunologia , Isquemia Miocárdica/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Infecções por Chlamydia/microbiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/microbiologia , Isquemia Miocárdica/mortalidade , Prognóstico , Taxa de SobrevidaAssuntos
Bacteriemia/microbiologia , Infecções por Campylobacter/sangue , Campylobacter fetus/isolamento & purificação , Idoso , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Bacteriemia/patologia , Infecções por Campylobacter/tratamento farmacológico , Infecções por Campylobacter/microbiologia , Humanos , Imunocompetência , Masculino , Resultado do TratamentoRESUMO
No disponible
Assuntos
Idoso , Masculino , Humanos , Bacteriemia , Resultado do Tratamento , Antibacterianos , Infecções por Campylobacter , Campylobacter fetus , ImunocompetênciaRESUMO
Chlamydia pneumoniae infection has long been suspected as a possible cause of atherosclerosis and has been frequently detected in atheromatous plaques of the coronary arteries. Nevertheless, its distribution is not correlated to the severity or extent of the disease, but it would support the hypothesis that the organism may be an active factor in the pathogenesis of atherosclerosis. A group of patients with stable angina were examined as to whether or not the positivity of antibodies against Chlamydia pneumoniae modified cellular populations as mechanisms responsible for the alterations of inflammatory response. We concluded that the presence of IgG anti-C. pneumoniae antibodies do not participate in the activation of inflammatory mechanisms that may intervene in the genesis of atherosclerosis in patients with stable angina.