Incidencia de diabetes mellitus tipo 1 en niños: resultados del registro poblacional de la Comunidad de Madrid, 1997–2005 / Incidence of type 1 diabetes mellitus in children: results from the population registry of the Madrid Region, 1997–2005

Fundamento y objetivo: La incidencia de diabetes mellitus (DM) tipo 1 presenta variaciones importantes en el ámbito mundial, tanto entre países europeos como entre regiones dentro de un mismo país. El objetivo de este estudio ha sido caracterizar los datos básicos de la incidencia y describir la epidemiología de la presentación de la DM tipo 1 en la Comunidad de Madrid. Material y método: Se incluyeron 1.130 casos nuevos de DM en menores de 14 años que fueron notificados al registro de DM desde enero de 1997 a diciembre de 2005. La exhaustividad del registro se evaluó a través del método de captura-recaptura. La comparación de incidencia entre diferentes grupos, así como la tendencia de la incidencia, se analizó mediante modelos de regresión de Poisson. Resultados: La tasa de incidencia en el período estudiado es de 15,9/100.000 personas-año (intervalo de confianza del 95%, 15,0–16,8). La exhaustividad es del 82%. La incidencia es de 12,1; 18,2, y 17,4 por 100.000 personas-año en los niños de 0–4; 5–9, y 10–14 años, respectivamente. La incidencia se ha mantenido estable en el período estudiado. El riesgo por edad presenta diferencias por sexo. Además, se observa una variación estacional, con mayor incidencia en los meses fríos. Conclusiones: La tasa de incidencia de DM tipo 1 se sitúa en un lugar intermedio respecto a las estimadas más recientemente en otras regiones españolas, y en el ámbito mundial la Comunidad de Madrid se sitúa entre los países con incidencia moderadamente alta. La incidencia en el período 1997–2005 se ha mantenido estable. En cuanto a la variación estacional, hay una mayor incidencia en los meses fríos (AU)

Background and objective: Incidence of type 1 diabetes mellitus (DM) varies importantly worldwide, including European countries, and even among regions within a country. The aim of this study is to describe the incidence of type 1 DM in the Madrid Region. Material and method: We included 1130 new cases of type 1 DM in children below 15 years of age, which were notified to the diabetes registry from January, 1997 to December, 2005. Case ascertainment was evaluated through the capture-recapture method. The data was analysed using Poisson regression models. Results: The incidence rate in this period was 15.9/100,000 persons-years (95% confidence interval, 15.0–16.8). Completeness of ascertainment was 82%. The incidence by age group was 12.1 (0–4 years), 18.2 (5–9 years) and 17.4 by 100,000 persons-years (10–14 years). The incidence data showed no significant changes in the studied period. We observed a seasonal variation in the incidence, with the greatest incidence in the cold months. Conclusions: The estimated incidence of type 1 DM ranks in an intermediate position with regard to that estimated more recently in other Spanish regions. During the period 1997-2005, the incidence has maintained stable in the Madrid Region (AU)

[Incidence of type 1 diabetes mellitus in children: results from the population registry of the Madrid Region, 1997-2005]. / Incidencia de diabetes mellitus tipo 1 en niños: resultados del registro poblacional de la Comunidad de Madrid, 1997-2005.

BACKGROUND AND OBJECTIVE: Incidence of type 1 diabetes mellitus (DM) varies importantly worldwide, including European countries, and even among regions within a country. The aim of this study is to describe the incidence of type 1 DM in the Madrid Region. MATERIAL AND METHOD: We included 1130 new cases of type 1 DM in children below 15 years of age, which were notified to the diabetes registry from January, 1997 to December, 2005. Case ascertainment was evaluated through the capture-recapture method. The data was analysed using Poisson regression models. RESULTS: The incidence rate in this period was 15.9/100,000 persons-years (95% confidence interval, 15.0-16.8). Completeness of ascertainment was 82%. The incidence by age group was 12.1 (0-4 years), 18.2 (5-9 years) and 17.4 by 100,000 persons-years (10-14 years). The incidence data showed no significant changes in the studied period. We observed a seasonal variation in the incidence, with the greatest incidence in the cold months. CONCLUSIONS: The estimated incidence of type 1 DM ranks in an intermediate position with regard to that estimated more recently in other Spanish regions. During the period 1997-2005, the incidence has maintained stable in the Madrid Region.