Effect of tyrosine kinase inhibitors on the glucose levels in diabetic and nondiabetic patients.

CONTEXT: Tyrosine kinase inhibitors (TKIs) are used in different types of cancers due to their good profile of adverse reactions and their convenience in the oral administration. Some studies describe that certain TKIs are associated with changes in the glycemic profile of the patients. AIMS: This study aims to determine if treatment with ITK affects to serum glucose levels in clinical practice. SETTINGS AND DESIGN: A retrospective study was carried out in 136 episodes (112 patients treated with sorafenib, sunitinib, imatinib, dasatinib, or nilotinib). SUBJECTS AND METHODS: The serum glucose levels were analyzed before treatment and after months 1, 2, 3, 6, 9, and 12 of treatment. STATISTICAL ANALYSIS USED: Statistical analysis was completed with SPSS version 20 for Windows. RESULTS: There were significant differences in the serum glucose levels before treatment between diabetic and nondiabetic patients, but not between the average blood glucose readings before treatment and the average of the subsequent readings, once their treatment had begun. CONCLUSIONS: The results of this study do not reproduce the results of the literature since changes in the serum glucose levels have not been found in this sample of patients.

Nutrición parenteral domiciliaria en paciente con enfermedad de Crohn; a propósito de un caso / Home parenteral nutrition in Crohn's disease patient; a case report

Paciente diagnosticada de Enfermedad de Crohn con patrón inflamatorio que evoluciona a estenosante-perforante, provocando una perforación abdominal con peritonitis fecaloidea. Es sometida a tres intervenciones quirúrgicas, derivando en numerosas complicaciones y una evolución clínica tórpida. Dado el estado de desnutrición al ingreso se le prescribe Nutrición Parenteral Total (NPT), prolongándose la administración durante más de 10 meses. En este periodo se le suspende durante 5 días, pero la persistencia de una fístula enterocutánea provoca la restauración de la NPT. Tras su estabilización clínica, la paciente es dada de alta hasta recuperación de su estado nutricional necesario para realizar una cirugía de reconstrucción del intestino, continuando con NPT en su domicilio. Después de 7 meses y medio, la paciente con un estado nutricional óptimo, es sometida a la intervención quirúrgica, evolucionando favorablemente y suspendiendo la NPT a los 9 días (AU)

Patient diagnosed with Crohn's Disease with inflammatory pattern that evolves stenosing-piercing, causing abdominal perforation and fecal peritonitis. She was underwent to three surgeries, leading to numerous complications and a torpid clinical course. Given the state of malnutrition on admission it was prescribed Total Parenteral Nutrition (TPN), extending the administration for more than 10 months. In this period the TPN is suspended for 5 days, but the persistence of an enterocutaneous fistula causes the restoration of the TPN. After clinical stabilization, the patient is discharged to recover her nutritional status necessary to perform a bowel reconstruction surgery, continuing with TPN at home. After 7 and a half months, the patient with an optimal nutritional status, undergoes surgery, evolving favorably and suspending the TPN at 9 days (AU)

[Home parenteral nutrition in Crohn's Disease patient: a case report]. / Nutrición parenteral domiciliaria en paciente con enfermedad de Crohn: a propósito de un caso.

Patient diagnosed with Crohn's Disease with inflammatory pattern that evolves stenosing-piercing, causing abdominal perforation and fecal peritonitis. She was underwent to three surgeries, leading to numerous complications and a torpid clinical course. Given the state of malnutrition on admission it was prescribed Total Parenteral Nutrition (TPN), extending the administration for more than 10 months. In this period the TPN is suspended for 5 days, but the persistence of an enterocutaneous fistula causes the restoration of the TPN. After clinical stabilization, the patient is discharged to recover her nutritional status necessary to perform a bowel reconstruction surgery, continuing with TPN at home. After 7 and a half months, the patient with an optimal nutritional status, undergoes surgery, evolving favorably and suspending the TPN at 9 days.