Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.

Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded ATXN1 with the transcriptional repressor CIC drives cerebellar Purkinje cell pathogenesis; however, the importance of this interaction in other vulnerable cells remains unknown. Here, we mutated the 154Q knockin allele of Atxn1154Q/2Q mice to prevent the ATXN1-CIC interaction globally. This normalized genome-wide CIC binding; however, it only partially corrected transcriptional and behavioral phenotypes, suggesting the involvement of additional factors in disease pathogenesis. Using unbiased proteomics, we identified three ATXN1-interacting transcription factors: RFX1, ZBTB5, and ZKSCAN1. We observed altered expression of RFX1 and ZKSCAN1 target genes in SCA1 mice and patient-derived iNeurons, highlighting their potential contributions to disease. Together, these data underscore the complexity of mechanisms driving cellular vulnerability in SCA1.

Patient Information and Informed Consent for Research in the Elderly: Lessons Learned from a Randomized Controlled Trial.

The informed consent (IC) of subjects participating in experimental studies is the mainstay to comply with the ethical principle of autonomy to ensure that the participation is voluntary. This experience was performed within the context of a single-center randomized clinical trial in elective prosthetic surgery. Obtaining IC in clinical trials is not without difficulties, and especially in the case of vulnerable populations it can be very challenging. This work aimed to identify the difficulties during the IC process for a clinical trial in subjects older than 65 years old and quantify and describe the use of IC in front of a witness. METHODS: This is a mixed methodology study with a qualitative part (focus group with 4 nurses involved in the inclusion of subjects) and a quantitative part describing the characteristics of patients who signed IC forms. RESULTS: The main difficulties identified are related to comprehension, sensory impairments, education level, and time. IC in front of witnesses was used in 20 patients out of 508. CONCLUSIONS: The participation of subjects older than 65 years old in clinical trials requires an adaptation of the process. The use of IC in front of a witness should always be considered in studies including elderly subjects.

Estrategias del equipo de salud para afrontar la muerte de niños y adolescentes con cáncer / Strategies by the Health Team for Coping with the Death of Children and Adolescents with Cancer

Introducción: La muerte en niños y adolescentes por cáncer suele ser difícil de afrontar por los profesionales de salud. Si no cuentan con modos adecuados para transitar estos duelos, pueden generarse problemas psicológicos, emocionales y físicos, exponiéndose a Burnout. Objetivo: Develar las estrategias utilizadas por profesionales y técnicos de salud de hospitales públicos chilenos para afrontar la muerte de infantes con cáncer. Métodos: Investigación cualitativa fenomenológica, realizada en cinco hospitales públicos en Santiago de Chile, entre mayo-septiembre del 2017. Población de 37 profesionales y técnicos de salud que vivenciaron morir niños y adolescentes con cáncer. Se efectuaron entrevistas en profundidad, guiadas por la pregunta "¿Cómo ha afrontado usted la muerte de los pacientes en su unidad?" Las narrativas se transcribieron y analizaron según las etapas de Streubert, se triangularon los datos hasta alcanzar la saturación. Resultados: Las principales estrategias fueron participar de ritos de despedida ante la muerte, realizar actividades recreativas con miembros del equipo fuera de la jornada laboral, hacer cambios en la rutina de trabajo, separar aspectos personales y profesionales. Al percibir un bajo apoyo de la institución, propusieron facilitar la asistencia al funeral, desarrollar intervenciones formales de apoyo en duelo, realizar intervenciones de autocuidado e incorporar el tema de la muerte en las inducciones laborales. Conclusión: Los profesionales y técnicos cuentan con estrategias para afrontar sus duelos. Sin embargo, requieren de apoyo formal de la institución, junto con capacitación continua en la temática. Es fundamental que la institución se implique en esta problemática(AU)

Introduction: Cancer deaths among children and adolescents are often difficult for health professionals to cope with. If they do not have adequate ways to deal with this grief, psychological, emotional and physical problems may arise, exposing them to burnout or the so called burned-out worker syndrome. Objective: To reveal the strategies used by health professionals and technicians in Chilean public hospitals to cope with the death of children with cancer. Methods: Qualitative and phenomenological research carried out in five public hospitals in Santiago, Chile, between May and September 2017. The population was made up of 37 health professionals and technicians who experienced the death of children and adolescents with cancer. In-depth interviews were conducted, guided by the following question: How have you coped with the death of patients in your unit? The narratives were transcribed and analyzed according to the stages described by Streubert. In addition, the data were triangulated until saturation was reached. Results: The main strategies were to participate in farewell rites in the face of death, to carry out recreational activities with team members outside the workday, to make changes in the work routine, as well as to separate personal and professional aspects. When perceiving low support from the institution, they proposed facilitating attendance at the funeral, developing formal bereavement support interventions, carrying out self-care, and incorporating the matter of death into work inductions. Conclusion: Professionals and technicians have strategies to cope with their bereavement. However, they need formal support from the institution, together with continuous training on the matter. It is essential for the institution to become involved in this issue(AU)

Cribado nutricional en pacientes quirúrgicos en un hospital universitario / Nutritional screening in surgical patients at a university hospital

Objetivo: conocer la prevalencia de riesgo de desnutrición de los pacientes quirúrgicos hospitalizados de un hospital de tercer nivel. Método: estudio descriptivo transversal unicéntrico con pacientes quirúrgicos hospitalizados. Se realizó un cálculo de tamaño muestral de 323 pacientes y se reclutaron por conveniencia. Se analizó el riesgo de desnutrición con la escala Nutrition Risk Screening 2002 y su asociación con diferentes variables sociodemográficas y clínicas. Para el análisis de datos se aplicaron las pruebas de Chi cuadrado, prueba exacta de Fisher, t de Student y U de Mann Whitney con una significancia estadística de p< 0,05. Resultados: participaron 318 pacientes, de los cuales el 74,8% era hombre, con una edad media de 62,2 años (DE: 15,54). En el cribado inicial, 80 participantes (25,2%) presentaron riesgo potencial de desnutrición mientras que tras el screening final, solo 12 presentaron riesgo de desnutrición real (3,8%). No se halló relación entre la desnutrición y el sexo aunque sí con la edad, aumentando el riesgo proporcionalmente (p< 0,001). Otros factores asociados fueron la necesidad de un cuidador/a (p= 0,001), el tipo de patología de ingreso (p= 0,034) y tener antecedentes personales oncológicos (p< 0,001) y de deterioro cognitivo (p= 0,001). Conclusiones: la prevalencia de desnutrición en pacientes quirúrgicos hospitalizados es baja y parece que aumenta con la edad, y con antecedentes personales de deterioro cognitivo y enfermedad neoplásica, aunque los resultados deben ser interpretados con cautela. Identificar la presencia de desnutrición al ingreso favorece el fomento de medidas de prevención que permitan implementar un plan nutricional y facilitar el seguimiento tras el alta.(AU)

Objectives: to understand the prevalence of the risk of malnutrition among hospitalized surgical patients in a tertiary hospital. Method: a descriptive cross-sectional single-centre study with hospitalized surgical patients. The sample size was calculated at 323 patients, and there was convenience recruitment. The malnutrition risk was analysed with the Nutrition Risk Screening 2002 scale, and its association with different sociodemographic and clinical variables. The Chi Square, Fisher’s Exact, Student’s t and Mann-Whitney tests were applied for data analysis, with a statistical significance of p< 0.05. Results: the study included 318 patients; 74.8% of them were male, with a mean age of 62.2 years (SD: 15.54). At the initial screening, 80 participants (25.2%) presented potential risk of malnutrition; while after the final screening, only 12 presented a real risk of malnutrition (3.8%). No relationship was found between malnutrition and gender, but it was found with age, with a proportional increase in risk (p< 0.001). Other factors associated were the need for a caregiver (p= 0.001), the type of condition at admission (p= 0.034) and having a personal background of neoplasia (p< 0.001) and cognitive deterioration (p= 0.001). Conclusions: there is a low prevalence of malnutrition among hospitalized surgical patients, and it seems to increase with age and with a personal history of cognitive deterioration and neoplasia, although these results must be interpreted with caution. The detection of malnutrition at admission will promote taking prevention measures, therefore allowing to implement a nutritional plan and facilitating follow-up after discharge.(AU)

Perception of support in professional's and technician's grief of pediatric intensive care units in public hospitals. / Percepción de apoyo en duelo por profesionales y técnicos de cuidados intensivos pediátricos de hospitales públicos.

INTRODUCTION: Death in childhood is a reality faced by health professionals, especially in highly com plex units such as intensive care ones. This leads to feelings of helplessness and frustration in health professionals, compromising their physical, emotional, and mental health, which is worsened by the feeling of low social support and poor preparation for coping with death and support for the patient's family. OBJECTIVE: To expose the perception of sorrow support of professionals and techni cians in pediatric intensive care units of public hospitals, after the death of the patients. SUBJECTS AND METHOD: Qualitative study with a phenomenological approach. 16 in-depth interviews were conduc ted with pediatric intensive care professionals and technicians from five public hospitals in Santiago, Chile. Inclusion criteria considered working for more than a year in the Unit, having experienced the death of patients, and recognizing that they have gone through a professional sorrow. The in terview focused on the following question: How have you experienced the sorrow support received after the death of patients in your unit? Once the narratives were transcribed, the phenomenological analysis and subsequent data triangulation were carried out, achieving saturation. RESULTS: It was observed that the participants feel little supported in their sorrows after the death of the patients, where there are obstacles to face the situation. Although facing death is something complex for the participants, they recognize that they can generate protection strategies and also feel supported by the people around them. Despite the complexity of this experience, the participants consider that there are lessons learned in facing death which leads them to give meaning to their professional work. CONCLUSION: Professionals need the recognition of deaths in the workplace and, therefore, formal and continuous support from their work team and institution.

Percepción de apoyo en duelo por profesionales y técnicos de cuidados intensivos pediátricos de hospitales públicos / Perception of support in professional's and technician's grief of pediatric intensive care units in public hospitals

INTRODUCCIÓN: La muerte en la infancia es una realidad a la que se ven enfrentados los profesionales de salud, especialmente en unidades de alta complejidad como son los cuidados intensivos. Esto genera en los profesionales impotencia y frustración, comprometiendo su salud física, emocional y mental, agravada por la sensación de bajo soporte social y deficiente preparación para el afrontamiento de la muerte y el apoyo a los familiares de sus pacientes. OBJETIVO: Develar la percepción de apoyo en duelo de profesionales y técnicos en unidades de cuidado intensivo pediátrico de hospitales públicos, tras la muerte de los pacientes. SUJETOS Y MÉTODO: Estudio cualitativo con enfoque fenomenológico. Se realizaron 16 entrevistas en profundidad a profesionales y técnicos de cuidados intensivos pediátricos de cinco hospitales públicos de Santiago. Como criterios de inclusión se consideraron el trabajar por más de un año en la unidad, haber vivenciado la muerte de pacientes, y reconocer que ha cursado un duelo profesional. La entrevista fue guiada por la siguiente pregunta: ¿Cómo ha vivenciado usted el apoyo en duelo recibido, tras la muerte de pacientes en su unidad? Una vez trascritas las narrativas se realizó el análisis fenomenológico y posterior triangulación de los datos, logrando la saturación. RESULTADOS: Se develó que los participantes se sienten poco apoyados en sus duelos tras la muerte de los pacientes, existiendo obstáculos para su afrontamiento. Aunque enfrentar la muerte es algo complejo para ellos, reconocen que son capaces de generar estrategias de protección y además se sienten apoyados por personas de su entorno. A pesar de lo complejo de esta experiencia, ellos consideran que existen aprendizajes al enfrentar la muerte que los lleva a dar sentido a su labor profesional. CONCLUSIÓN: Los profesionales requieren que las pérdidas en el ámbito laboral sean reconocidas, y por ello, contar con un apoyo formal y continuo de su equipo de trabajo e institución.

INTRODUCTION: Death in childhood is a reality faced by health professionals, especially in highly com plex units such as intensive care ones. This leads to feelings of helplessness and frustration in health professionals, compromising their physical, emotional, and mental health, which is worsened by the feeling of low social support and poor preparation for coping with death and support for the patient's family. OBJECTIVE: To expose the perception of sorrow support of professionals and techni cians in pediatric intensive care units of public hospitals, after the death of the patients. SUBJECTS AND METHOD: Qualitative study with a phenomenological approach. 16 in-depth interviews were conducted with pediatric intensive care professionals and technicians from five public hospitals in Santiago, Chile. Inclusion criteria considered working for more than a year in the Unit, having experienced the death of patients, and recognizing that they have gone through a professional sorrow. The in terview focused on the following question: How have you experienced the sorrow support received after the death of patients in your unit? Once the narratives were transcribed, the phenomenological analysis and subsequent data triangulation were carried out, achieving saturation. RESULTS: It was observed that the participants feel little supported in their sorrows after the death of the patients, where there are obstacles to face the situation. Although facing death is something complex for the participants, they recognize that they can generate protection strategies and also feel supported by the people around them. Despite the complexity of this experience, the participants consider that there are lessons learned in facing death which leads them to give meaning to their professional work. CONCLUSION: Professionals need the recognition of deaths in the workplace and, therefore, formal and continuous support from their work team and institution.

Ultrasound as a potential process to tenderize beef: Sensory and technological parameters.

In this study, the effects of high intensity ultrasound (HIU), applied after storage, on the physical, microstructural, and sensory characteristics of beef were evaluated. Samples of four beef m. Longissimus dorsi muscle were stored in vacuum at 4 °C for 0, 7 or 14 days and then ultrasonicated (40 kHz, 11 W/cm2) for 60 min. Beef stored for 7 d prior to ultrasonication displayed increased pH and luminosity, reduced redness and saturation value, higher hue angle, and variable changes in water holding capacity. Shear force of sonicated meat was lower than that of control samples at all storage times. HIU also increased the tenderness and fragmentation of meat (P < 0.05) measured by texture profile analysis. The microstructure of sonicated meat showed a visible reduction in the size of fascicles, greater interfibrillary spaces, and thinner endomysium. These effects were enhanced with the storage of meat previous to HIU treatment. Meat stored for 14 d and then treated with ultrasound was perceived to have a more intense fresh meat smell and oily flavor (P < 0.05). However, it was also perceived to be a paler grayish brown color compared to control samples stored for the same duration. Ultrasonicated meat also presented a greater intensity of metallic taste (P < 0.05) and a more tender and moist texture (P < 0.05). Overall, application of HIU of meat after meat was stored affects textural and microstructural properties and accelerates aging without negative impacts on other technological and sensory attributes. Therefore, HIU application after storage has potential as a safe method for tenderizing bovine meat when handled under the conditions in this study.

Open-label randomized controlled trial to compare wound dressings for patients undergoing hip and knee arthroplasty: study protocol for a randomized controlled trial.

BACKGROUND: Surgical wounds are covered to prevent bleeding, absorb the exudates, and provide a barrier against external contamination. Currently, in our hospital, after orthopedic surgery, traditional occlusive dressing of sterile gauze and non-woven hypoallergenic adhesive tape is placed. Some of the newest dressings have been shown to reduce the incidence of blisters compared with traditional dressing or colloid adhesive dressings. However, there are no comparative evaluations between the different types of dressings and their contribution to the overall results of the healing process. METHODS/DESIGN: This is a randomized, controlled, open-label trial to compare five types of dressings used in total knee and hip arthroplasty surgical wounds. A total of 550 patients will be randomly allocated to one of the following dressings: (1) traditional occlusive dressing, (2) Aquacel Surgical®, (3) Mepilex® Border Post-Op, (4) OpSite Post-Op Visible, or (5) UrgoTul® Absorb Border. The dressing assigned is placed right after surgery. Patients will be followed up to 14 days after surgery when the dressing is definitively removed and will be tracked up to 3 months to record any late complications. During the immediate postoperative period and patient hospitalization and at the ambulatory visits after discharge, every time that the dressing is changed, nurses perform the study assessments. The main study outcome will be the percentage of patients with skin integrity at all times when the dressing has been changed. Skin integrity is a composite of the absence of blisters, erosion, erythema, maceration, swelling, wound dehiscence, and purulent exudates. Secondary outcomes include time to first change of dressing; percentage of patients with presence/absence of blisters, erosion, erythema, maceration, swelling, wound dehiscence, and purulent exudates; number of dressing changes needed; days of hospital stay; and nurse and patient satisfaction. Differences in the main variable between each treatment group and group 1 will be tested by means of a chi-squared test or Fisher's exact test. Subgroup analyses of diabetic and non-diabetic patients, patients with a body mass index of more than 30 or not more than 30, and type of surgery (hip or knee) are planned. DISCUSSION: The results of this study will be useful for clinical decision making by giving information on the contribution of the dressings studied to the outcome of the wound and may also show which dressing offers better results depending on the characteristics of patients. TRIAL REGISTRATION: This trial has been registered at ClinicalTrials.gov ( NCT03190447 ). Retrospectively registered on 16 June 2017.

Changes in Consumer Purchases in Stores Participating in an Obesity Prevention Initiative.

INTRODUCTION: From 2011 to 2014, small stores in three communities participated in a community-wide obesity prevention initiative. The study aimed to determine how participation in the initiative influenced store environments and consumer purchases. STUDY DESIGN: Pre- and post-intervention without control. Structured observations of the store environments and intercept surveys of adult shoppers at all stores, and of children at two stores, conducted at baseline and follow-up. Manager/owner interviews regarding perceived impacts of the intervention conducted at follow-up. SETTING/PARTICIPANTS: Shoppers at nine small stores in three diverse, low-income communities in Northern California. INTERVENTION: The store interventions were determined locally with combinations of strategies such as product displays, healthier options, marketing and promotion, store layout, and facility improvements that were implemented to varying degrees at each site. MAIN OUTCOME MEASURES: Changes in store environments and purchases of select foods and beverages. RESULTS: Stores experienced consistent, but not always significant, declines in purchases of sweets and chips and increases in purchases of fruits and vegetables at select stores. Decreases in purchases of targeted sugar-sweetened beverages were offset by increases in purchases of other sugar-sweetened beverages. Changes in store environments and promotional activities varied widely from store to store and corresponded to variations in changes in purchasing. The owners/managers perceived benefits to their bottom line and community/customer relations, but challenges were identified that may account for the varied degree of implementation. CONCLUSIONS: Substantive improvements in fruit and vegetable availability and promotion were needed to achieve a measurable impact on purchases but reducing purchases of unhealthy foods, like sweets and chips, required a less consistent intensive effort. These findings suggest it may be challenging to achieve the consistent and targeted implementation of changes and ongoing promotional efforts at a large enough proportion of stores where residents shop that would be required to get measurable impacts at the community level. SUPPLEMENT INFORMATION: This article is part of a supplement entitled Building Thriving Communities Through Comprehensive Community Health Initiatives, which is sponsored by Kaiser Permanente, Community Health.

Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.

Pathogenic strains of Vibrio cholerae are responsible for endemic and pandemic outbreaks of the disease cholera. The complete toxigenic mechanisms underlying virulence in Vibrio strains are poorly understood. The hypothesis of this work was that virulent versus non-virulent strains of V. cholerae harbor distinctive genomic elements that encode virulence. The purpose of this study was to elucidate genomic differences between the O1 serotypes and non-O1 V. cholerae PS15, a non-toxigenic strain, in order to identify novel genes potentially responsible for virulence. In this study, we compared the whole genome of the non-O1 PS15 strain to the whole genomes of toxigenic serotypes at the phylogenetic level, and found that the PS15 genome was distantly related to those of toxigenic V. cholerae. Thus we focused on a detailed gene comparison between PS15 and the distantly related O1 V. cholerae N16961. Based on sequence alignment we tentatively assigned chromosome numbers 1 and 2 to elements within the genome of non-O1 V. cholerae PS15. Further, we found that PS15 and O1 V. cholerae N16961 shared 98% identity and 766 genes, but of the genes present in N16961 that were missing in the non-O1 V. cholerae PS15 genome, 56 were predicted to encode not only for virulence-related genes (colonization, antimicrobial resistance, and regulation of persister cells) but also genes involved in the metabolic biosynthesis of lipids, nucleosides and sulfur compounds. Additionally, we found 113 genes unique to PS15 that were predicted to encode other properties related to virulence, disease, defense, membrane transport, and DNA metabolism. Here, we identified distinctive and novel genomic elements between O1 and non-O1 V. cholerae genomes as potential virulence factors and, thus, targets for future therapeutics. Modulation of such novel targets may eventually enhance eradication efforts of endemic and pandemic disease cholera in afflicted nations.

Kaiser Permanente's Community Health Initiative in Northern California: evaluation findings and lessons learned.

PURPOSE: To describe the evaluation findings and lessons learned from the Kaiser Permanente Healthy Eating Active Living-Community Health Initiative. DESIGN: Mixed methods design: qualitative case studies combined with pre/post population-level food and physical activity measures, using matched comparison schools for youth surveys. SETTING: Three low-income communities in Northern California (combined population 129,260). SUBJECTS: All residents of the three communities. INTERVENTION: Five-year grants of $1.5 million awarded to each community to support the implementation of community- and organizational-level policy and environmental changes. Sectors targeted included schools, health care settings, worksites, and neighborhoods. MEASURES: Reach (percentage exposed) and strength (effect size) of the interventions combined with population-level measures of physical activity (e.g., minutes of physical activity) and nutrition (e.g., fruit and vegetable servings). ANALYSIS: Pre/post analysis of population level measures, comparing changes in intervention to comparison for youth survey measures. RESULTS: The population-level results were inconclusive overall, but showed positive and significant findings for four out of nine comparisons where "high-dose" (i.e., greater than 20% of the population reached and high strength) strategies were implemented, primarily physical activity interventions targeting school-age youth. CONCLUSION: The positive and significant changes for the high-dose strategies suggest that if environmental interventions are of sufficient reach and strength they may be able to favorably impact obesity-related behaviors.

Prevalencia y localización anatómica radiográfica de dientes supernumerarios de los pacientes que asistieron al Centro de Imágenes de la Facultad de Odontología de la Universidad de El Salvador de julio 2007 a julio 2008 / Prevalence and radiographic anatomical location of supernumerary teeth of patients who attended the Imaging Center of the Faculty of Dentistry of the University of El Salvador from July 2007 to July 2008

Diente Supernumerario: es el aumento del número de dientes en la dentición normal. Más frecuentes en el Maxilar que en la Mandíbula, prevalece en hombres, afectan todas las series dentarias, pueden ser únicos o múltiples y retenidos o erupcionados, condicionan alteraciones eruptivas, desviaciones de los dientes vecinos, diastemas, reabsorciones radiculares y quistes. Este estudio descriptivo permitió conocer la prevalencia y localización anatómica radiográfica de dientes supernumerarios de los pacientes que asistieron al centro de imágenes de la Facultad de Odontología de la Universidad de El Salvador durante Julio 2007 a Julio 20008. El Universo de estudio fueron cincuenta y siete Radiografías Panorámicas Digitales que representa el 5.77% de la población total; de este porcentaje presentaron dientes supernumerarios el 63.10% en el Maxilar y el 36.90% en la Mandíbula. La zona que presenta mayor cantidad de Dientes Dupernumerarios en el Maxilar es la Anterior con el 66.15% y en la Mandíbula la Premolar con el 84.21%. El Supernumerario más frecuente en el Maxilar es el Mesiodens con el 60% y en la Mandíbula las Premolares con 84.47%. El Diente Supernumerario con la forma anatómica más definida es la Paramolar con el 41.66% y en la Mandíbula la Premolar con el 90.91%. El rango de edad con mayor porcentaje es de 11 a 20 años con el 43.85%. El género que predomina es el Masculino con 54.39%. En el Maxilar Superior, el 81.53% de Dientes Supernumerarios se observan retenidos; y en la Mandíbula, el 84.21%. La presencia de quistes se encuentra con el 4.61 % en el Maxilar Superior y el 10.52% en la Mandíbula.

Supernumerary tooth: it is the increase in the number of teeth in normal dentition. More frequent in the Maxilla than in the Mandible, it prevails in men, affects all dental series, can be single or multiple and retained or erupted, conditions eruptive alterations, deviations of neighboring teeth, diastemas, root resorption and cysts. This descriptive study allowed to know the prevalence and radiographic anatomical location of supernumerary teeth of the patients who attended the imaging center of the Faculty of Dentistry of the University of El Salvador from July 2007 to July 20008. The universe of study was fifty-seven X-rays Digital Panoramas that represent 5.77% of the total population; Of this percentage, 63.10% had supernumerary teeth in the Maxilla and 36.90% in the Mandible. The area with the greatest amount of Dupernumerary Teeth in the Maxilla is the Anterior with 66.15% and in the Mandible the Premolar with 84.21%. The most frequent Supernumerary in the Maxilla is the Mesiodens with 60% and in the Mandible the Premolars with 84.47%. The Supernumerary Tooth with the most defined anatomical shape is the Paramolar with 41.66% and in the Mandible the Premolar with 90.91%. The age range with the highest percentage is from 11 to 20 years with 43.85%. The predominant gender is the Male with 54.39%. In the upper jaw, 81.53% of supernumerary teeth are observed retained; and in the Jaw, 84.21%. The presence of cysts is found with 4.61% in the Upper Maxilla and 10.52% in the Mandible.